Active chemical ionization mass spectrometry

Arnold, F., and G. Hauck, Lower Stratosphere Trace Gas Detection Using Aircraft-Borne Active Chemical Ionization Mass Spectrometry, Nature, 315, 307-309 (1985). 

Knop, G., and F. Arnold, Atmospheric Acetonitrile Measurements in the Tropopause Region Using Aircraft-Borne Active Chemical Ionization Mass Spectrometry, Planet. Space Sci., 35, 259-266 (1987b). 

Very recently, active chemical ionization mass spectrometry (ACIMS) was employed for stratospheric trace gas detection [57]. Here ions are created in the stratospheric medium by an electron bombardment ion... 

Those are, for instance, known as active chemical ionization mass spectrometry (ACIMS) for atmospheric trace-gas measurements in the chemosphere, proton transfer reaction mass spectrometry (PRT-MS), selected ion flow tube mass spectrometry (SIFT-MS), ion-molectrle reaction mass spectrometry (IMR-MS), ion attachment mass spectrometry (lAMS), and ion mobility spectroscopy (IMS). Those have now become part of the exterrsive resources of experimental techniques dedicated to all the scientific fields, especially such as fundamentals of gas-phase ion kinetics and thermochentistry, physical organic chemistry, atmospheric chemistry, interstellar chemistry, plasma, and combustion chemistry, radiation chemistry, analytical chemistry, and irltimately even medicine and biology. 

Negative-Ion Chemical Ionization Mass Spectrometry and Ames Mutagenicity Tests of Granular Activated Carbon Treated Waste Water... 

Murphy, A.T. Kasper, S.C. Gillespie, T.A. DeLong, A.R Determination of Xanomeline and Active Metabolite, N-Desmethylxanomeline, in Human Plasma by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry, J. Chromatogr B. Biomed Appl. 668, 273-280 (1995). 

Murphy, A.T. et al., Determination of xanomeline and active metabolite, jV-desmcthylxanomclinc in human plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry, J. Chromatogr. B. BiomedAppl., 668, 273,1995. 

Further studies" of chemical ionization mass spectrometry (CIMS) applied to steroids show that the method has considerable potential for molecular weight determinations, and for the recognition of functional groups with active hydro-... 

Hunt, D.F. McEwen, C.N. Upham, R.A. Determination of active hydrogen in organic compounds by chemical ionization mass spectrometry. Anal. Chem. 1972, 44, 1292-1294. 

Several methods have been developed specifically for naphthenic acids, a class which includes the surface active carboxylate surfactants. Naphthenic acids are present as a complex mixture of a number of homologues with only a small range in molar mass (166-450 mol/g), little change in solubility character, and have been difficult to assay using conventional analytical methods. Methods such as negative ion-mode mass spectrometry using fast atom bombardment (FABMS), have been successfully applied to the analysis of naphthenic acid mixtures [93, 94], Other promising techniques include fluoride ion chemical ionization mass spectrometry (FI-MS) [95], and electrospray ionization mass spectrometry (ESIMS), which may allow for the quantification of the various naphthenic acid fractions [96]. 

Cristoni S, Bernardi LR, Gerthoux P, Gonella E, MocareUi P. 2004. Surface-activated chemical ionization ion trap mass spectrometry in the analysis of amphetamines in diluted urine samples. Rapid Commun Mass Spectrom 18 1847. 

In addition to the human labor problems created by chemical separation and ultra-clean environments, both neutron activation and thermal Ionization mass spectrometry require unique equipment that Is not available to most research groups. Because of these factors progress In trace metal analysis has been slow and practical data acquisition from large populations Is essentially non-existent ... 

Recently, a LC/MS method to determine OTA in wine and grape extracts by using Surface-Activated-Chemical-Ionization and multistage fragmentation mass spectrometry (LC/SACI-MS3), was proposed (Flamini et al., 2007). SACI is an ionization source developed to analyze medium-high polar compounds in a wide range of m/z ratios (100-4000 Da). This device, used in determination of compounds such as... 

Flamini, R., Dalla Vedova, A., De Rosso, M. and Panighel, A. (2007) A New Sensitive and Selective Method for Analysis of Ochratoxin A in Grape and Wine by direct liquid chromatography/surface activated chemical ionization-tandem mass spectrometry, Rapid Commun. Mass Spectrom. 21(22), 3737-3742. 

Figure 8.3. The SACI/MS2 and MS3 fragmentation patterns of OTA and ZAN [M+H]+ ions. (Reprinted from Rapid Communications in Mass Spectrometry 21, Flamini et al., A new sensitive and selective method for analysis of och-ratoxin A in grape and wine by direct liquid chromatography/surface activated chemical ionization-tandem mass spectrometry, p. 3738, Copyright 2007, with permission from John Wiley Sons, Ltd.)...

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