Action unpredictability

Negotiations with Japan appear to be terminated to all practical purposes with only the barest possibility that the Japanese Government might come back and offer to continue. Japanese future action unpredictable but hostile action possible at any moment. If hostilities cannot, repeat cannot be avoided the United States desires that Japan commit the first overt act... Measures should be carried out so as not, repeat not, to alarm civil population or disclose intent. 

They are prepared by the action of HNO2 on aromatic amines. The amine is dissolved in excess of mineral acid and sodium nitrite is added slowly until a slight excess of HNO2 is present. The reaction is usually carried out in ice-cold solution. The solution then contains the diazonium salt of the mineral acid used, anhydrous diazonium salts of unpredictable stability may be precipitated with complex anions like PF , SnCl6 BF4 . 

There is some uncertainty connected with testing techniques, errors of characteristic measurements, and influence of fectors that carmot be taken into account for building up a model. As these factors cannot be evaluated a priori and their combination can bring unpredictable influence on the testing results it is possible to represent them as additional noise action [4], Such an approach allows to describe the material and testing as a united model — dynamic mathematical model. 

For many applications it is not possible to put a component into service to test its durability. Similarly, in product testing one cannot always simulate full service conditions in one test or things become too complicated - for example, time-dependent loading plus abrasion plus environmental ageing. Car tyres have a complicated pattern of cornering, sports surfaces are subject to the actions of different sports and pipes in the North Sea have almost unpredictable wave motions superimposed. No simulation test will reproduce service conditions perfectly, therefore, in accordance with Section 4.13, the test has to be restricted to the critical agents of degradation. 

From a pharmacological point of view the first two strategies raise several distinct disadvantages. First, the exact structures of these fullerene-based systems in solution are usually unknown and, especially for polymeric materials inhomogeneous samples are frequently obtained. Furthermore, in many cases the amount of incorporated fullerene is not clearly determined. In addition, the presence of other molecules like the hosts or polymeric residues can cause unpredictable side effects and in no case the mode of action or activity can doubtlessly be associated with the fullerenes. However, for systematic investigations on structure-function relationships or extensive testings of toxicological or human availability properties, the use of structurally well-defined and characterized materials is mandatory. 

An illustration of the variable responses to nicotine concerns aphids. In an experiment, 2 per cent of an insect population died or became moribund when exposed to 0.0001 M nicotine solution, 48 per cent were affected when the concentration was 0.0025 M, and 98.5 per cent when the concentration was 0.012 M. The concentrations of nicotine required to affect all the insects alike varied more than 120-fold.21 The pharmacology of nicotine as studied in mammals is notably complex and unpredictable, partly because many sites of action are involved. Its effect on different human individuals is also diverse, but it has not been adequately investigated, particularly in view of the fairly well established fact that amblyopia and Buerger s disease occur in relatively rare cases directly because of its use.22... 

Nicotine affects nearly every physiological system of the body (Le Houezec and Benowitz 1991). However, the effects are complex and unpredictable due to actions on multiple sites, and the stimulation-desensitization of nicotinic receptors. 

Exceeding these known limits will result in unpredictable actions usually resulting in significantly reduced performance, and a resulting increase in human error. Investigators and designers should be constantly on the alert for opportunities to make a system more reliable by considering the worker-machine interface and search for every opportunity to make the system less error-prone and more error-tolerant. 

A generally accepted definition of the Precautionary Principle has never been brought forward. According to a popular definition (Wikipedia 2006) The precautionary principle is a moral and political principle which states that if an action or policy might cause severe or irreversible harm to the public, in the absence of a scientific consensus that harm would not ensue, the burden of proof falls on those who would advocate taking the action. The precautionary principle is most often applied in the context of the impact of human actions on the environment and human health, as both involve complex systems where the consequences of actions may be unpredictable. ... 

The triazolopyridine trazodone does not have an appreciable effect on the re-uptake of the neurotrans-mittors dopamine or noradrenaline. It is a weak inhibitor of serotonin re-uptake but is a potent antagonist of the serotonin 5-HT2 receptor. Clinical experience has shown unpredictable efficacy. Trazodone has little antimuscarinic activity and has little if any action on cardiac conduction. Like mianserin it can therefore safely be used in patients for which anticholinergics are contraindicated and there are no absolute contraindications for patients with concomitant diseases of the cardiovascular system. 

Although hydralazine is available for intravenous administration and has been used in the past for hypertensive emergencies, it is not generally employed for this purpose. The onset of action after intravenous injection is relatively slow, and its actions are somewhat unpredictable in comparison with those of several other vasodilators. 

Heparin is prescribed on a unit (lU) rather than milligram basis. Tlie dose must be determined on an individual basis. Heparin is not absorbed after oral administration and therefore must be given parenterally. Intravenous administration results in an almost immediate anticoagulant effect. There is an approximate 2-hour delay in onset of drug action after subcutaneous administration. Intramuscular injection of heparin is to be avoided because of unpredictable absorption rates, local bleeding, and irritation. Heparin is not bound to plasma proteins or secreted into breast mUk, and it does not cross the placenta. 

Care should be taken not to administer any partial agonist or drug with mixed opioid receptor actions to patients receiving pure agonist drugs because of the unpredictability of both drugs effects reduction of analgesia or precipitation of an explosive abstinence syndrome may result. 

Cyclophosphamide disturbs the mechanisms associated with DNA synthesis and cell proliferation by alkylating DNA in proliferating and nonproliferating cells. Its mechanisms of immunosuppressive effects are similar to its antineoplastic actions. Cyclophosphamide affects both B and T cells, but it produces more toxicity to B cells because they recover slowly. It has some unpredictable effects on T-cell-mediated immunity where it actually augments some T-cell-mediated responses however, the overall response is inhibitory. 

The herb St. John s wort (Hypericum perforatum) has a number of constituent parts, including hyperforin, which is currently being studied as the responsible constituent for the antidepressant action. The herb contains at least ten compounds that can have an unpredictable effect on the consumer. 

Flumazenil reverses the sedative actions of benzodiazepines. However, its duration of action is short and its antagonism of respiratory depression unpredictable. Therefore, the use of flumazenil in benzodiazepine overdose must be accompanied by adequate monitoring and support of respiratory function. 

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