Overall Responsibility

So one can say the designer should not carry all these responsibilities. True but if the responsibility is not delegated to one person, you allow for problems to develop. Perhaps a certain qualified manager (the designer s boss) should have the responsibility. For a small operation it is usually its owner who may or may not properly delegate specific responsibilities. 

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The technical review team should compare the overall response related to process safety, environmental, health, and quality capability-related items to the data gathered through questionnaires or visits. Does their practice match their policy ... 

Successful implementation requires that the new system is reviewed by all those who will use it, or by representatives of these groups. Generally a small team will be appointed with overall responsibility for implementation this team will include representatives from every major group that will use the new system. Once this team has agreed on the overall implementation strategy, each member of the team will work with one or more user groups to explain the new system and its implementation. 

When selecting die members of a team diat will bear overall responsibility for emergency plamiing, the following considerations are important. 

The operational model, as presented, shows dose-response curves with slopes of unity. This pertains specifically only to stimulus-response cascades where there is no cooperativity and the relationship between stimulus ([AR] complex) and overall response is controlled by a hyperbolic function with slope = 1. In practice, it is known that there are experimental dose-response curves with slopes that are not equal to unity and there is no a priori reason for there not to be cooperativity in the stimulus-response process. To accommodate the fitting of real data (with slopes not equal to unity) and the occurrence of stimulus-response cooperativity, a form of the operational model equation can be used with a variable slope (see Section 3.13.4) ... 

As reviewed thermoplastics (TPs) being viscoelastic materials respond to induced stress by two mechanisms viscous flow and elastic deformation. Viscous flow ultimately dissipates the applied mechanical energy as frictional heat and results in permanent material deformation. Elastic deformation stores the applied mechanical energy as completely recoverable material deformation. The extent to which one or the other of these mechanisms dominates the overall response of the material is determined by the temperature and by the duration and magnitude of the stress or strain. The higher the temperature, the most freedom of movement of the individual plastic molecules that comprise the... 

Likewise, the longer the duration of material stress or strain, the more time for viscous flow to occur. Finally, the greater the material stress or strain, the greater the likelihood of viscous flow and significant permanent deformation. For example, when a TP product is loaded or deformed beyond a certain point, the material comprising it yields and immediate or eventually fails. Conversely, as the temperature or the duration or magnitude of material stress or strain decreases, viscous flow becomes less likely and less significant as a contributor to the overall response of the material and the essentially instantaneous elastic deformation mechanism becomes predominant. 

Summation The overall response is the arithmetic sum of the contribution brought by each receptor (e.g., NKX and NK2). Capsaicin-induced contraction of rat isolated urinary bladder, electrical field stimulation (EFS)-induced nonadrenergic, noncholinergic contraction of the isolated guinea pig bronchus or renal pelvis when SP metabolism is blocked by peptidase inhibitors are all examples of summation. Both NK and NK2r antagonists are required to abolish such kind of response, but each antagonist substantially reduces the response... 

Specialization Each receptor contributes to morphologically (e.g., phasic vs. tonic) or temporally (early vs. late) distinct components of the overall response. This is the case of prolonged EFS-induced nonadrenergic, noncholinergic contraction the guinea pig colon or rat urinary bladder, where the fast and late components of the contraction are mediated by NKxror NK2r, respectively... 

Supra-additivity This is a special case of cooperation where the blockade of a single receptor is not sufficient to reduce the overall response. Capsaicin-induced nonadrenergic, noncholinergic contraction in the guinea pig ileum or common bile duct can be inhibited only when at least two different TK receptors are blocked (e.g., NKX + NK2, NKX + NK3, NK2 + NK3)... 

Interestingly, all these monoclonal antibodies have a poor antitumor activity when used as single agents, with overall response rates of about 10%. Thereby, these monoclonal antibodies have all been approved in combination with classical cytotoxic agents or radiation therapy. 

Structure and responsibility. These are concerned with ensuring that there is a senior manager with overall responsibility for the programme and that the responsibilities of other staff are clearly identified and communicated. These individual responsibilities should fit with the overall policy and objectives. 

Your name must be inserted here. As the employer fie sole trader, senior partner or managing director) you have overall responsibility for health and safety. 

If you are not always there, or do not have time to manage on a day-to-day basis, you can delegate this role to someone else, eg director, manager or supervisor. You will need to ensure that they keep you fully Informed of health and safety matters - It will still be your overall responsibility. 

CHEMFET with antibody It has been shown that the immunological coupling response of some of these electrodes might be a minor component of the overall response, which would make these sensors difficult to use as immunoelectrodes In general, these electrodes as yet have insufficient sensitivity for most practical immunoassays. 

The distinction between detection and identification is important, since it may affect the overall response time and options. A detection occurs when a chosen parameter exceeds its threshold value. The detection may be nonspecific—that is, it registers the occurrence of an anomaly but does not necessarily indicate the presence of a particular threat substance. By contrast, identification establishes the identity of the threat substances in a given set. Nonspecific detection systems may have a relatively rapid response time compared with that of specific identification systems, but the former typically provide a lower confidence level that a threat substance is in fact present. In some cases, an alarm from a rapid but nonspecific detection system may be used... 

Given the large amount of data generated by surveillance cameras and the infrequency of attacks, human monitors would require a technological alert system, and the overall response time to a possible attack might well be reduced if... 

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