Acids, conjugate

Conjugated terminal fluoroenynes add water to the double bond at -5 C to form a-fluoro allemc acid fluondes. At 20 C, the allenic acid fluorides and concentrated sulfunc acid give y- and 8-laaones (equation 1) In the presence of concentrated sulfuric acid, conjugated nontermmal fluoroenynes add water to the triple bond and then to the double bond to form a-fl uoro-P-diketones and exocyclic a-fluoroenones [/] (equation 2). 

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Basu S., Wickstrom E. Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insu-lin-like growth factor 1 for increased cellular uptake. Bioconjug. Chem. 1997 8 481-488. 

Bile acid conjugates la 376 Bile acid methyl esters lb 446,448 Binding agent, influence on staining la 123 S-Bioallethrine la 359... 

C18-0095. The pH of a formic acid/formate buffer solution is 4.04. Calculate the acid/conjugate base ratio for this solution. Draw a molecular picture that shows a small region of the buffer solution. (You may omit spectator ions and water molecules.) Use the following symbols ... 

Tall oil fatty acids consist of resin acids (25% to 30%) and of a mixture of linolic acid, conjugated Cig fatty acids (45% to 65%), oleic acid (25% to 45%), 5,9,12-octadecatrienic acid (5% to 12%), and saturated fatty acids (1% to 3%). Resin acids are abietinic acid, dehydroabietic acid, and others. Properties of fatty acids are shown in Table 6-1. 

Guyan et al. 1990) have used several markers of lipid peroxidation (9-cis-, 11-tmns-isomer of linoleic acid, conjugated dienes and ultraviolet fluorescent products) to demonstrate significant increases in the duodenal aspirate after secretin stimulation in patients with acute and clinic pancreatitis. They interpreted this as indicating induction of hepatic and pancreatic drug-metabolizing enzymes in the face of a shortfidl of antioxidant defences, more marked in chronic pancreatitis. Subsequent studies in patients with chronic pancreatitis have confirmed decreased serum concentrations of selenium, -carotene and vitamin E compared with healthy controls (Uden et al., 1992). Basso aol. (1990) have measured increases in lipid peroxides in the sera of patients with chronic... 

ABA-l-GAT Arsanilic acid conjugated with the synthetic polypeptide l-GAT AC Adenylate cyclase ACAT Acyl-co-enzyme-A acyltransferase... 

Doria, F. Richter, S.N. Nadai, M. Colloredo-Melz, S. Mella,M. Palumbo, M. Freccero, M. BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photo-cytotoxic agents. J. Med. Chem. 2007, 50, 6570-6579. 

Hepatic metabolism No Yes oxidation and hydroxylation induces liver enzymes to increase its metabolism and other drugs Yes oxidation and conjugation Yes oxidation and glucuronide conjugation Yes glucuronic acid conjugation Induces its own metabolism in normal volunteers... 

Atrazine, used as a selective pre- and post-emergence herbicide to control annual weeds in several crops, is the most representative compound of this group. It is also used as a non-selective herbicide in non-crop areas. After absorption, the compound is metabolized to dealkylated and deisopropy-lated derivatives. The unchanged compound and its metabolites are excreted in urine, where they can be detected by chromatography or enzyme-linked immunosorbent assay (Lucas et al., 1993). A mercapturic acid conjugate of atrazine has also been found in urine samples of workers spraying this herbicide (Lucas et al., 1993) (Table 6). 

The urine samples were analyzed using a modified version of a published method.8 The method involved fortification of the urine samples with an internal standard 3,4,5-trichloro-2-pyridinyl, which is a structural isomer of the 3,5,6-TCP metabolite of chlorpyrifos hydrolysis of labile acid conjugates to 3,5,6-TCP solvent extraction derivitization to the f-butyl-dimethylsilyl ester of 3,5,6-TCP and subsequent negative-ion chemical ionization gas chromatography/mass spectrometry (GC/MS) analysis. Creatinine was determined in urine using a modification of a method of Fabiny and Erting-shausen.9... 

Jackson HL, Cardounel AJ, Zweier JL, and Lockwood SF. 2004. Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate. Bioorganic Medicinal Chemistry Letters 14(15) 3985-3991. 

Fonseca ASC, Gonfalves MST, Costa SPG (2007) Photocleavage studies of fluorescent amino acid conjugates bearing different types of linkages. Tetrahedron 63 1353-1359... 

Wiener and co-workers used folic acid-conjugated Gd(DTPA)-PAMAM dendrimers for visualizing the high-affinity folate receptor, overexpressed in many tumors.201 The contrast agent accumulated in the cells, resulting in a remarkable contrast enhancement on 7)-weighted images. 

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