Acceptable Daily Intakes

The safety of lecithin is also confirmed by the World Health Organi2ation (WHO). WHO has not set any acceptable daily intake (ADI) to lecithin as... 

Aspartame (L-aspartyl-L-phenylalanine methyl ester [22839-47-0]) is about 200 times sweeter than sucrose. The Acceptable Daily Intake (ADI) has been estabUshed by JECFA as 40 mg/kg/day. Stmcture-taste relationship of peptides has been reviewed (223). Demand for L-phenylalanine and L-aspartic acid as the raw materials for the synthesis of aspartame has been increasing, d-Alanine is one component of a sweetener "Ahtame" (224). 

JECEA reviewed the safety studies of glutamate and endorsed its safety by allocating an Acceptable Daily Intake (ADI) for L-glutamic acid and its monosodium, potassium, ammonium, calcium, and magnesium salts as being "not specified." The scientific committee for food of EC concurred (40). 

Vanillin is Hsted in the Code of Federal Regulations by the FDA as a Generally Recogni2ed As Safe (GRAS) substance. The Council of Europe and the FAO/WHO Joint Expert Committee on Eood Additives have both given vanillin an unconditional Acceptable Daily Intake (ADI) of 10 mg/kg. 

Toxicologists tend to focus their attention primarily on c.xtrapolations from cancer bioassays. However, tlicrc is also a need to evaluate the risks of lower doses to see how they affect the various organs and systems in the body. Many scientific papers focused on tlic use of a safety factor or uncertainty factor approach, since all adverse effects other than cancer and mutation-based dcvclopmcnUil effects are believed to have a tlu cshold i.e., a dose below which no adverse effect should occur. Several researchers have discussed various approaches to setting acceptable daily intakes or exposure limits for developmental and reproductive toxicants. It is Uiought Uiat an acceptable limit of exposure could be determined using cancer models, but today tliey arc considered inappropriate because of tlircsholds. ... 

Acceptable Daily Intake (ADI) An estimate similar in concept to the RfD, but derived using a less strictly defined methodology. RfDs have replaced ADIs as the USEPA s (Agency) preferred values for use in evaluating potential noiicarcinogenic health effects resulting from exposure to a chemical. 

There have been numerous reports of possible allergic reactions to mercury and mercury salts and to the mercury, silver and copper in dental amalgam as well as to amalgam corrosion products Studies of the release of mercury by amalgams into distilled water, saline and artificial saliva tend to be conflicting and contradictory but, overall, the data indicate that mercury release drops with time due to film formation and is less than the acceptable daily intake for mercury in food . Further, while metallic mercury can sensitise, sensitisation of patients to mercury by dental amalgam appears to be a rare occurrence. Nevertheless, there is a growing trend to develop polymer-based posterior restorative materials in order to eliminate the use of mercury in dentistry. 

The determination of an acceptable dose for humans involves the application of uncertainty factors to reflect the fact that, unlike the experimental animal, there is wide variability and susceptibility of response in the genetically diverse human population. Variations in gender, age, hormonal and disease status can affect the response to a chemical. In order to minimise any potential risks, uncertainty factors are applied to the NOAEL to arrive at a reduced exposure that is considered tolerable - namely the acceptable daily intake or ADI. These are usually tenfold for variations in susceptibility amongst the human population (the intra-species factor) and tenfold for the potential... 

Several aspects of the problem of herbicides being contaminated with nitrosamines, and the resulting inadvertent introduction of nitrosamines into the environment, will be discussed in other papers in this symposium. Unrecognized until less than five years ago, the situation has inspired intense debate and prompted several of the environmental chemistry studies mentioned in this paper. Like the presumed threat from the in vivo nitros-ation of pesticide residues, discussions sometimes lack the type of anticipated dose and effect calculations just mentioned. Unlike the active ingredients, whose benefits can justify residue tolerances and acceptable daily intakes, nitrosamine contaminents afford no known benefits, and the desirability of minimizing their levels is undisputed. 

NOAEL (no-observed-adverse-effect level) is defined as the highest dose at which no adverse effects are observed in the most susceptible animal species. The NOAEL is used as a basis for setting human safety standards for acceptable daily intakes (ADIs), taking into account uncertainty factors for extrapolation from animals to humans and inter-individual variabilities of humans. The adequacy of any margin of safety or margin of exposure must consider the nature and quality of the available hazard identification and dose-response data and the reliability and relevance of the exposure estimations. In some cases, no adverse endpoint can be identified such as for many naturally occurring compounds that are widespread in foods. In that case, an ADI Not Specified is assigned. ... 

The quantitative measurement of toxicity level is expressed by parameters like NOEL (no observed effect level), NOAEL (no observed adverse effect level), and ADI (acceptable daily intake). The NOEL values are divided by 100 to obtain ADI values. The 100 safety factor derives from 10 x 10, where the 10s represent the animal-to-human conversion rate and the human variability factor. Currently, the most useful index of safety is the ADI, expressed as milligrams of test substance per kilogram of body weight (ppm), with the recommendation not to eat more than the ADI per day. The FDA, EU, and WHO agree on the ADI principle. 

ADI = acceptable daily intake, estimate of amount of a substance in food or drinking water, expressed as mg/kg body weight, that can be ingested daily over a lifetime without appreciable risk (weight of standard human = 60 kg) bw = body weight. 

AOELinhaiative Can be substituted by the AOELsystemic In the case that neither acceptable operator exposure level (AOEL) values are available, the proposed or established acceptable daily intake (ADI) value can be considered. 

Drinking water quality should be taken into account from a human toxicological viewpoint because the main source of drinking water is river water. Japanese regulatory procedures allocate 10% of the acceptable daily intake (ADI) in principle to the intake from drinking water. 

American Conference of Governmental Industrial Hygienists Acceptable Daily Intake... 

In September 1999, the United Nations World Health Organization (WHO) and the Food and Agriculture Organization (FAO) Joint Meeting on Pesticide Residues (JMPR) established an acute reference dose (RfD) of 0.1 mg/kg bw and a chronic RfD, or acceptable daily intake (ADI), of 0.01 mg/kg bw/day. (See FAO/WHO Report 153, Pesticide Residues in Pood, Section 4.7, Chlorpyrifos, 1999.)... 

The acceptable daily dose of a toxicant (in mg/(kg x day)), D-j, relative to chronic human health effects, is central to PPLV calculations. Table II lists seven sources of information from which D.j values may be drawn. From this, it is seen that, if there is available an ADI (Acceptable Daily Intake) value originating with the World Health Organization (7), then that figure should be used as Qj. 

An added ten-fold safety factor shall be added in setting pesticide reference doses (RfDs) (i.e. acceptable daily intakes) to account for the unique risks faced by infants and children, unless the EPA administrator has solid data supporting a determination that existing RfDs are fully health protective, even for infants and that exposures are fully and accurately characterized and... 

Most countries restrict the maximum degree of amidation to a 25% maximum. High methoxyl pectins are naturally present in fruit and escape restrictions on use for that reason. Low methoxyl pectins are treated as additives and have restrictive acceptable daily intakes (ADIs). 

Acceptable daily intake for 70-kg person (with a safety factor of 1000) Concentrations developed for noncarcinogenic effects 0.031 mg daily (equivalent to 0.443 pg/kg BW daily) 6... 

Acceptable daily intake, total PCBs, Scandinavia <0.2 mg, equivalent to about 2.8 pg/kg BW daily for a 70-kg person 13... 

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