Y-Herpesviruses

HVS is a T-lymphotropic y-herpesvirus that causes a fatal lymphoproliferative disease in several non-human primates. HVS is closely related to the human B-lympho-tropic y-herpesvirus Epstein-Barr virus. ECRF3, also referred to as HVS ORF74, is a gene displaying homology to CCRl and CXCRl and 2, CMV-encoded US28 and KSHV... 

Rhesus monkey rhadinovirus (RhRV) ORF R3 or R4 (no consensus in annotation, hereafter called R4) is the only y-herpesvirus, besides KSHV known to encode a CC-chemokine. R4 is approximately 40% identical to vCCLl and vCCL2. It is stiU unknown whether R4 is a functional homolog of vCCLl or of vCCL2. 

The subfamily of y-herpesviruses is further divided into two subgroups, y-1 herpesviruses, such as EBV, and y-2 herpesviruses, such as H. saimiri and HHV-8. It is a peculiar feature of y-herpesviruses, in particular y-2 herpesviruses, to contain a number of genes with homology to cellular genes (Neipel et al. 1997 Meinl et al. 1998). 

M3 y-Herpesvirus Broad specificity CC, CXC, C, CX3C chemokines Block receptor interaction and GAG-binding site... 

Herpesvirus saimiri (HVS) is a primate-restricted T-lymphotropic y-herpesvirus that is closely related to the Epstein-Barr virus (EBV), a human B-lymphotropic y-herpesvirus (53,58). HVS does not cause disease in its natural host the squirrel monkey, but induces fatal leukemias and lymphomas in other primates. ECRF3 is one of 14 ORFs of HVS that lack homologs in EBV, and that have sequence homology with known cellular proteins (53). 

Moore, P. S., and Chang, Y. (2001) Molecular virology of Kaposi s sarcoma-associated herpesvirus. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356,499-516. 

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Aita, K., Jin, Y., Iris, H., Takahashi, I., Kobori, K., Nakasato, Y., Kodama, H., Yanagawa, Y., Yoshikawa, T., Shiga, J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection A case report and discussion. Human Pathol. 2001 32 887—889... 

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Various bacterial vectors have been used to express a number of bacterial B. pertussis, S. pneumoniae, Y. pestis, and L. monocytogenes), viral (herpesvirus, influenza virus, human immunodeficiency virus, simian immunodeficiency virus, and hepatitis B virus), and parasitic (5. mansoni, and L. major) antigens. Significant improvements in attenuation of bacteria, and the stability, localization, and expression levels of heterologous antigens are required to market the bacterial vector-based vaccines for use in humans or animals. 

Suzuki Y, Inagi R, Aono T, Yamanishi K, Shiohara T. Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998 134(9) 1108-12. 

Katano H, Sato Y, Kurata T, et al. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi s sarcoma, and multicentric Castleman s disease. Virology. 2000 269 335-344. 

Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N., and Yamanishi, K. (1998). Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. J. Virol. 72, 6104-6112. 

Yang, T.Y., S.C. Chen, M.W. Leach, D. Manfra, B. Homey, M. Wiekowski, L. Sullivan, C.H. Jenh, S.K. Narula, S.W. Chensue, and S.A. Lira. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi s sarcoma. J Exp Med 191 445-54, 2000. 

Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIMS) a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int 2006 55 1-8. 

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