Viruses mouse leukemia

Hepatite Virus NS3/4A having the pyrrolidine-5,5-trans-lactam skeleton [83], starting from (R)- and (S)-methionine, respectively. The key step is the addition of the proper silyl ketene acetal to an iminium ion, e.g., that generated by treatment of the intermediate 177 with boron trifluoride, which provided the adduct 178 with better diastereoselectivity than other Lewis acids. Inhibitors of hepatitis C virus NS3/4A were efficiently prepared by a similar route from (S)-methionine [83]. The addition of indole to a chiral (z-amino iminium ion was a completely diastereoselective step in a reported synthesis of tilivalline, a natural molecule which displays strong cytotoxicity towards mouse leukemia L 1210 [84]. 

Tung, J. S., Yoshiki, T., and Fleissner, E. (1976) A core polyprotein of murine leukemia virus on the surface of mouse leukemia cells. Cell 9, 573-578. 

Basic science research at The Section/DM. The NIH/NCI grant-supported retroviral mouse leukemia work at the Section of Clinical Tumor Virology Immunology included the early study of graft-versus-leukemia reactions in Rauscher virus-infected mice [261a, b]. 

Sinkovics JG, Berlin BA, Howe CD. Occurrence of low leukemogenic but immunizing mouse leukemia virus in tissue culture. National Cancer Institute Monograph. 1965 22 349-67. 

Sinkovics JG, ShuUenberger CC, Howe CD, Benin BA. Leukemogenic effect of human leukemic materials in combination with inactivated mouse leukemia virus. Canctn. 1967 20 846-50. 

RNA tumor viruses (Gillespie et al, 1972), Rous sarcoma and mouse leukemia virus (Lai and Duesberg, 1972), poliovirus and equine encephalitis virus (Armstrong et al, 1972), Sindbis virus (Eaton et al,... 

MLV-related virus (spleen necrosis virus, mouse, and feline leukemia viruses). 

A number of studies have analyzed the efficacy of berberine in vivo against transplanted hematologic tumor cell fines as well as during virus-induced leukemia. Specifically, it has been showed that berberine has antitumoral potential in vivo against transplanted mouse acute lymphocytic leukemia P388 [112] and acute myeloid leukemia WEHI-3 [151]. fii addition, this alkaloid was able to inhibit the progression of erythroleukemia induced by mouse rebovirus. Friend, in immunocompetent mice [152]. 

Charman, H.P., N. Kim, M. White, and R.V. Gilden. 1974. Failure to detect, in human sera, antibodies cross-reactive with group specific antigen of mouse leukemia virus. J. Nat. Cancer Inst. 52 1409-1413. 

Feddersen, R.M. Van Ness, B.G. (1990). Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells. Mol. Cell. Biol. 10, 569-576. 

Pretazettine (395) has been the subject of numerous biological studies, and it has been shown to exhibit a number of interesting activities (96,97,101,178-187). For example, 395 was found to inhibit HeLa cell growth as well as protein synthesis in eukaryotic cells by interfering with the peptide bond formation step (97,101). Furthermore, pretazettine inhibited the purified RNA-dependent DNA polymerase (reverse transcriptase) from avian myeloblastosis virus, a typical C-type virus (178), in an unusual fashion since it physically combined with the polymerase enzyme itself rather than interacted with the nucleic acid template. Pretazettine also exhibited antiviral activity against the Rauscher leukemia virus in mouse embryo cell cultures by suppressing viral replication (179). 

Jaenisch R. Retroviruses and embryogenesis Microin-jection of Moloney leukemia virus into midgestation mouse embryos. Cell 1980 19 181-8. 

To find whether the reduced foci formation was due to inhibition of MSV (M) replication, the effect of these compounds on virus growth was studied. Secondary mouse embryo cell cultures were infected with MSV (M) at the rate of 0.03 competent MSV infectious units per cell and treated with the compounds at different doses after the infection by the focus assay in the presence of an optimal amount of MLV (M) (1.01 10s Leukemia Vims Helper Units) according to Hirschman etal.33 Similarly treated uninfected cultures were trypsinized at the same time, and cells were counted. 

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