Cells mouse leukemia

Diastovaricias I (70) and II (71) are produced by Streptomyces diastochromogenes. Diastovaricias I and II are active against Friend mouse leukemia cells. Spectral data were used to determine the stmctures (226). 

Fluid-phase uptake of macromolecules by cells in general is a slow process, and most administered macromolecules are eliminated from the host before any significant cellular uptake takes place. If, however, the macromolecule contains a moiety that is compatible with a receptor on a specific cell surface, then the macromolecule is attracted to the cell surface and the uptake is enhanced. This maximizes the opportunity for specific-cell capture. This type of cell-specific targeting has been developed to hepatocytes, with galactosamine to T lymphocytes, with anti-T cell antibodies and to mouse leukemia cells, with fucosylamine and other biomolecules. 

Hayakawa Y, Nakagawa M, Kawai H, Tanabe K, Nakayama H, Shimazu A, Seto H, Otake N. (1985) Spicamycin, a new differentiation inducer of mouse myeloid leukemia cells (Ml) and human promyelocytic leukemia cells (HL-60). Agric Biol Chem 49 2685-2691. 

Fig. 4. Flow cylometric patterns for L12I0 mouse leukemia cells in the absence (A) and presence (B) of vinblastine (9 hr exposure to 8 nM vinblastine). (Data courtesy of Dr. Linda Borman, Vermont Regional Cancer Center.)...

Overexpression of PKC( has been reported to be required for mitogenic maturation of Xenopus oocytes and led to deregulation of growth control in mouse fibroblasts (Berra et al., 1993). However, these effects of PKC in Xenopus oocytes seem not to be clear (Carnero et al., 1995). In U937 monocytic leukemia cells PKC( overexpression decreased proliferation rate and saturation density, indicating the induction of differentiation (Ways et al.,... 

In 1997, Chakrabarty et al. reported the isolation of 9-carbethoxy-3-methylcarba-zole (5) and 9-formyl-3-methylcarbazole (6) from the roots of M. koenigii (17). These metabolites are the first 9-formyl and 9-carbethoxy carbazole derivatives obtained from plant sources. 9-Formyl-3-methylcarbazole (6) showed weak cytotoxicity against both mouse melanoma B16 and adriamycin-resistant P388 mouse leukemia cell lines. The structural assignment of these two alkaloids was based on the IR- and H-NMR spectra which were lacking any signal of an NH group. Additional structural support for 9-carbethoxy-3-methylcarbazole (5) was provided by the similarity of the UV absorption spectrum with that of a synthetic sample, obtained by reaction of 3-methylcarbazole with ethyl chloroformate in the presence of base. Further structural support for 9-formyl-3-methylcarbazole (6) was derived from a comparison of the UV spectrum and the IR carbonyl absorption (1696 cm ) with those of an authentic sample of 9-formyl-3-methylcarbazole (1700 cm ), prepared by the treatment of 3-methylcarbazole (2) with 98% formic acid (17) (Scheme 2.3). 

Human myeloid leukemia cell differentiation protein Mcl-l Mouse Bid... 

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