Resistance to tumors

In addition, polyelectrolytes such as poly(acrylic acid-alt-maleic anhydride) (pyran) are reticuloendothelial stimulants, induce resistance to tumor growth [462,463] and show interferon-inducing ability and antiviral activity. The pyran activity may be dependent upon molecular weight. Low molecular weight materials of narrow polydispersity activate macrophages however antitumor activity does not appear to be molecular weight dependent [460]. 

Caulin, C., Ware, C. F., Magin, T. M., and Oshima, R. G. (2000). Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. /. Cell Biol. 149, 17-22. 

Fabris M, Quartuccio L, Vital E, Pontarini E, Salvin S, Fabro C et al (2013) The TTTT B lymphocyte stimulator promoter haplotype is associated with good response to rituximab therapy in seropositive rheumatoid arthritis resistant to tumor necrosis factor blockers. Arthritis Rheum 65 88-97... 

A). Yet another DNAhelicase, a subunit of transcription factor II (TFIIh, p. 1628), is defective in tri-chothiodystrophy (TTD, see Box 27-A). Another gene which helps to prevent aging is KLOTHO. First identified in mice, it encodes a transmembrane protein that has sequence similarities to P-glucosidases. Some mice with mutations in the tumor suppressor p53 (Box 11-D) have enhanced resistance to tumors but age rapidly. ... 

Figure 5.22 Structure of the P-glycoprotein pump, which confers multidrug resistance to tumor cells, (a) Schematic structure of the P-glycoprotein pump.

JuY, D., and L. Chedid Comparison between macrophage activation and enhancement of non-specific resistance to tumors by mycobacterial immunoadjuvants. Proc. Natl. Acad. Sci. 72,4105(1975)... 

In conclusion, all of us should be encouraged to look for a useful place for polyanions in regard to host resistance to tumor growth. This report demonstrates that certain polyanions can be clinically useful when toxicity is removed. Polyanions are controlling factors in cell physiology, and their clinical potential in the control of pathophysiology is only in its infancy. 

The ideal stent would be resistant to tumor ingrowth and migration. Researchers have been trying for some years to produce an uncovered stent with a coating material on the metallic mesh that would resist tumor ingrowth. Such a stent would have the optimal properties of covered stents (i.e., no tumor ingrowth) and uncovered stents (i.e., no migration). 

F. Suzuki, R.B. Pollard, S. Uchimura, T. Munakata, and H. Maeda, Role of natural killer cells and macrophages in the nonspecific resistence to tumors in mice stimulated with SMANCS, a polymer-conjugate derivative of neocarzinostatin. Cancer Res., 50 (13), 3897-3904,1990. 

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