Uterus

ACS Symposium Series American Chemical Society Washington, DC, 1980. 

Still V5X higher than for [Pt(NH3)i,] (0.25%). The spread In Pt concentrations after 7 d Is nearly 40-fold. 

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Cotarnine resembles hydrastinine (p. 167) in its pharmacological effects, but Its action on the uterus is less marked. It does not constrict the arterioles and appears to have a depressant action on the heart. Magidson and Gorbovizki have shown 1 that the Schiff s bases formed by the condensation of aldehydes with 1-aminomethylanhydrocotarnine have a marked local anaesthetic action but are irritant. 

Pharmacological Action. As already pointed out, cularine shows some resemblance to papaverine and hydrastine in action (p. 196). The M.L.D. (mgm./kilo.) for mice by intravenous injection of ochotensine is 10-6 i 0-54 so that it seems to be the most toxic of the fifteen corydalis alkaloids examined by Anderson and Chen, who also state that it stimulates isolated guinea-pig or rabbit uterus, inhibits isolated rabbit-intestine and induces a fall in blood pressure on intravenous injection in etherised cats. 

Reynolds and Waud found that capaurine produced paralysis on injection into the lymph sac of frogs, and convulsions when injected into mice or rabbits in doses of 100-200 mgm./kilo. It depressed the activity of the heart, intestine and uterus. The methyl ether caused convulsions in frogs, but otherwise acted like capaurine. 

According to Powell and Chen, gramine, used as the unstable hydrochloride, m.p. 191° (dec.), raises the blood pressure in anaesthetised cats in Small doses, but lowers it in doses of 30 to 40 mgm. per kilo., with a secondary rise. It reduces the chief effects of adrenaline without reversal. The toxic dose for rats is about 63 mgm./kilo. Supniewski and Serafinowna state that gramine excites the central nervous system in mammals, but in large doses causes paralysis. At 1 in 25,000 it causes contraction of the isolated uterus. 

Action on smooth muscle (uterus, blood vessels, intestine, etc.). 

According to White, alstoninc sulphate causes contraction and increased tone in isolated rabbit uterus and induces a fall in blood pressure in the anaesthetised cat, which is unaffected by atropine. 

Chen et al. state that dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers blood pressure, depresses respiration, inhibits isolated rabbit intestine and contracts isolated guinea-pig uterus. It has a weak analgesic, antipyretic action. Chen and Rose found that the convulsions induced by injection of dendrobine can be controlled by use of sodium isoamylethylbarbiturate they appear to be central in origin due to action on the cord and medulla. 

The median lethal dose of lunacrine hydrochloride is 78-7 3-8 mgm. per kilo given intravenously in mice. Oral doses of 1 gramme of lunamarine are not fatal. The m.l.d. of lunacridine by mouth is 1,097 167 mgra. per kilo. Limamarine stimulates isolated rabbit intestine and uterus, but lunacrine and lunacridine inhibit peristaltic movement of the isolated intestine. All three alkaloids reduce arterial blood pressure in cats. ... 

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