Guinea pig uterus

Chen et al. state that dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers blood pressure, depresses respiration, inhibits isolated rabbit intestine and contracts isolated guinea-pig uterus. It has a weak analgesic, antipyretic action. Chen and Rose found that the convulsions induced by injection of dendrobine can be controlled by use of sodium isoamylethylbarbiturate they appear to be central in origin due to action on the cord and medulla. 

Selected entries from Methods in Enzymology [vol, page(s)] Phosphatidylinositol-specific phospholipases C from Bacillus ce-reus and Bacillus thuringiensis, 197, 493 assays for phosphoinosi-tide-specific phospholipase C and purification of isozymes from bovine brain, 197, 502 properties of phospholipase C isozymes, 197, 511 phosphatidylinositol-specific phospholipase C from human platelets, 197, 518 purification of guinea pig uterus phos-phoinositide-specific phospholipase C, 197, 526. 

PONCE-MONTER, H., CAMPOS-LARA, G., PEDRON, N., DE LA TORRE, L., VILLANUEVA, T., GALLEGOS, A., ROMO DE VIVAR, A., AZPEITIA, E., PEREZ, A.J., The zoapatle. XV. Activity of 16 alpha-hydroxy-ent-kauran-19-oic acid isolated from Montanoa hibiscifolia, and its methyl ester on rat and guinea pig uterus., J. Ethnopharmacol., 1988, 24, 127-134. 

A study by Pitcher in 1916 found scullcap extract to have very weak ability to inhibit the contractility of excised guinea pig uterus, and no effect on the uterus in living animals that received what was considered to be a normal dose (Tyler, 1993). Two species of scullcap (S. galericulata andS. scordiifolia) studied in 1957 by Kurnakov were also found to show no antispasmodic activity in various small animals (Tyler, 1993). 

Milgrom, E., Perrot, M., Atger, M., and Baulieu, E.-E., Progesterone in uterus and plasma. V. An assay of the progesterone cytosol receptor of the guinea pig uterus. Endocrinology (Baltimore) 90, 1064-1070 (1972). 

LlltUtrln. Lutrexin. A uterus-relaxing factor obtained from the corpus luteum of sow ovaries and standardized for potency in terms of units of activity on the guinea pig uterus. Ref JAm. Med. Assoc. 156, 1252 (1954),... 

Corlumine, also a phthalideisoquinoline base, slightly augments the contractility of the isolated guinea pig uterus in concentrations of 1 100,000. Five times this concentration of corlumine induces spasm (146). 

Umbellatine, isolated from species of Berberis, has been studied by Gupta and Kahali (169). The isolated guinea pig uterus shows increased tonus and contractility when exposed to concentrations of 1 150,000. Doses of 2.0 mg./kg. produce an even more pronounced effect on the cat uterus in situ. The action is considered to be a cholinergic one. 

This alkaloid, isolated from various species of Calycanthus, is a convul-sant poison in warm-blooded animals. Calycanthine (1 40,000) greatly increases the tonus and movements of the isolated rabbit uterus. The isolated guinea pig uterus, however, shows only a feeble response to concentrations of 1 10,000 (173). 

Hordenine resembles ephedrine in many of its pharmacological actions. However, on the isolated guinea pig uterus, concentrations ranging from 1 250,000 to 1 1,250 are without effect. The tonus and movements of the uterus in vivo are augmented by doses of 1,0 mg./kg., the response increasing with the dosage (217). 

Six alkaloids from two species of Lycopodium have been studied by Lee and Cheit (221). Lycopodine, complanatine, obscurine, and alkaloid L9 all caused contraction of the isolated rabbit uterus in dilutions of 1 40,000 to 1 10,000. Lycopodine exhibited the most powerful action. Lycopodine and lkaloids L8 and L9 also produced contraction of the isolated guinea pig uterus in the same concentration as above. Marier and Bernard found that lycopodine and annotinine caused contraction of quiescent strips of rat, guinea pig, and rabbit uterus and augmented the movements of those preparations exhibiting spontaneous activity. The effective con-... 

Paipunine is one of numerous alkaloids isolated from various species of the plant family Stemonaceae. Paipunine was isolated and its pharmacology studied by Lee and Chen (254). Concentrations varying from 1 400,0 0 to 1 100,000 caused contraction of the isolated guinea pig uterus. Paipunine is a convulsant poison, the chief site of action being the medulla. 

Dorje, F.. Friebe, T., Tacke, R., Mutschler, E. and Lambrecht, G. (1990) Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus. Naunyn-Schrruedeberg s Arch. Pharmacol. 342 284-289. 

Some reports indicate that mugwort has been used as an abortifacient or in abortifacient formulas (Jamwal and Anand 1962 Riddle 1997 Saha et al. 1961 Wichtl 2004). No stimulant action of mugwort was observed in isolated guinea pig uteruses (Saha et al. 1961). 

In isolated rabbit and guinea pig uteruses, an aqueous extract of calendula exhibited uterotonic activity (Shipochliev 1981). The relevance of that finding to human use is unknown. 

A1935 study indicated that lavender stimulated uterine contractions in isolated pregnant guinea pig uteruses (Superbi and Crispolti 1935). No other information on the safety of lavender in pregnancy was identified. 

Uterine stimulant effect - in vitro (rabbit and guinea pig, uterus), cone, used not stated, unspecified conditions. IIId.2 Analgesic - in vivo (TP, mouse), dose not stated. 

Of the ten presumably new but unclassified alkaloids, isolated by Chou from Corydalis ambigua (Item 8 list, p. 170), four have been examined pharmacologically by Chen, Anderson and Chou, who find that alkaloids B and L, given intravenously in sub-lethal doses, produce catalepsy in mice and monkeys and a similar action is shown by L in cats. (Wang and Lu had already found that B and K resembled bulbocapnine in action.) Alkaloids J and M induce convulsions in lethal, or near lethal, doses in mice. All four have a similar depressant action on the heart in frogs, and in etherised cats they eause a fall in arterial blood pressure. In dilute solution they stimulate isolated rabbit intestine but relax it at higher concentrations. All induce contraction of isolated guinea-pig uterus. The M.L.D. (mgm./kilo.) by intravenous injection in mice are as follows B, 108 J, 42 L, 150 M, 41. 

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