Effects on the Ovaries and Uterus

Cyclophosphamide and vincristine are examples of alkylating agents capable of inducing gonadal dysfunction. Premature menopause is a primary outcome of exposure to these agents. Amenorrhea and abnormal hormonal levels are characteristics of the ovarian dysfunction induced by cyclophosphamide. 

Premature ovarian failure can be induced in offspring exposed in utero by active metabolites such as 6-mercaptopurine. Tamoxifen (treatments for breast cancer) and clomiphene (to induce ovulation) are antiestrogens that can inhibit uterine decidual induction in pseudopregnant rats. 

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