Antipyretic action

The suppression of malarial fever by quinine is etiological. However, quinine also reduces other febrile temperatures to normal, analogous to the other antipyretic drugs, i.e., by adjustment of the temperature-regulating centers, primarily through increased heat loss, assisted somewhat by diminished heat production. 

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Chen et al. state that dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers blood pressure, depresses respiration, inhibits isolated rabbit intestine and contracts isolated guinea-pig uterus. It has a weak analgesic, antipyretic action. Chen and Rose found that the convulsions induced by injection of dendrobine can be controlled by use of sodium isoamylethylbarbiturate they appear to be central in origin due to action on the cord and medulla. 

Corticosteroids are generally recommended, but there is no convincing evidence of adrenocortical insufficiency in thyroid storm their benefits may be attributed to their antipyretic action and stabilization of blood pressure. 

Vincamine (91) is the major alkaloid of V. minor, a plant used against headache and vertigo. It exerts a sedative CNS action and produces a fall in blood pressure. The principal activity is a moderate cerebral vasodilation. Clinical studies have demonstrated that i.v. administration of 91 to humans reduces the arterial blood pressure and increases cerebral blood flow and oxygen consumption. The improved cerebral hemodynamic conditions significantly and positively affect the state of patients with advanced arteriosclerosis with beneficial effects on memory, concentration, and behavior. It has thereafter been introduced under several trade names as a pharmaceutical in many European countries (232). Vobasine (32) has been widely studied it exhibits a weak CNS depressive, analgesic, and antipyretic action (21). 

Phenazone. Equimolar amounts of phenylhydrazine and ethyl acetoacetate are heated for 8 hours at 125°. The resulting phenyl-3-methyl-5-pyrazolone is dissolved in anisole and heated to 135°. Methyl bromide is passed through (bubbled into) the solution for 10 hours at 135°, and the anisole is removed by steam distillation. Phenazone is extracted from the remaining residue with chloroform and the chloroform is distilled or evaporated off The residue is recrystallized from ether. Mp 111-113°. Dosage 300 to 600 mg. This drug also has antipyretic action (reduces fever) and can cause rashes, nausea, and fainting. 

Acetylsalicylic acid (ASA) exerts an antiinflammatory effect, in addition to its analgesic and antipyretic actions. 

OE103 Delphaut, J., J. Balansard, and P. OE115 Route. Pharmacodynamic investigations of some plant drugs alleged to have an antipyretic action. C R Seances Soc Biol Ses Fil 1941 135 OE116... 

Antipyretic action Salicylates lower the elevated body temperature. Hypothalamic thermoregulatory centre acts as a thermostat of the body which maintains the balance between heat production and heat loss. Salicylates reset the hypothalamic thermostat which is disturbed during fever. They do not affect the heat production but they increase the heat loss by causing vasodilatation and sweating. The antipyretic action of salicylates is probably due to the inhibition of PG synthesis. 

It is a potent antiinflammatory agent. It has poor analgesic and antipyretic action. Mechanism of action is similar to other NSAIDs. 

It is indole acetic acid derivative possessing potent antiinflammatory property and having a good analgesic and antipyretic action also. Mechanism of action is same as other NSAIDs. 

Ketorolac has antiinflammatory and antipyretic action that, together with its analgesic effects. 

Apart from anthelmintic property, thiabendazole also possesses antiinflammatory, analgesic and antipyretic actions. It also inhibits development of eggs of worms and kills the larvae. 

Their antipyretic action means that NSAIDs do not reduce normal body temperature or elevated temperatures in heat... 

Clinical use Metamizol is the water-soluble sodium sulfonate of amidopyrine. After oral administration it is rapidly hydrolyzed to the active 4-methyl-amino-antipyrine and metabolized to various metabolites (Levy et al., 1995 scheme 47). Metamizol has strong analgesic, spasmolytic and antipyretic action, but no anti-inflammatory properties. The exact mechanism of action is unknown but may include inhibition of prostaglandin synthesis. Inhibition of both COX isoenzymes has been demonstrated, although only in extremely high concentrations, thus questioning the relevance of this activity. 

A9-Tetrahydrocannabinol (A9-THC) is considered to be the predominant compound in preparations of C. sativa (marijuana, hashish, bhang) that is responsible for the central nervous system effects in humans. The recognized central nervous system responses to these preparations include alterations in cognition and memory, euphoria, and sedation. Potential therapeutic applications of cannabis preparations that are of either historical or contemporary interest include analgesia, attenuation of the nausea and vomiting of cancer chemotherapy, appetite stimulation, decreased intestinal motility of diarrhea, decreased bronchial constriction of asthma, decreased intraocular pressure of glaucoma, antirheumatic and antipyretic actions, and treatment of convulsant disorders. These effects have been reviewed recently (Howlett, 1995). 

Pyrazolo[2,3-a]imidazole possesses sedative and antipyretic action. Imidazo[2,l-fc]-[l,3,4]thiadiazoles are antithrombotic and thrombolytic agents. Furo[3,2-c]isoxazol-5-ones and their enantiomeric or racemic mixtures are used in the production of antitumor agents obtained from methyl-L-acosaminide and -daunosaminide. 

Correct answer = C. Among the NSAIDs, aspirin is among the worst for causing gastric irritation. Aspirin is an effective analgesic and is used to reduce muscle pain. It also has antipyretic actions so that it can be used to treat fever. Because of its anti-inflammatory properties, aspirin is used to treat pain related to the inflammatory process, for example, in the treatment of rheumatoid arthritis. Low doses of aspirin also decrease the incidence of transient ischemic attacks. 

The pharmacology of these alkaloids has been discussed on numerous occasions (2, 3, 22, 23, 39-50). Mitragynine and, to a lesser extent, mitraphylline, exert a general depressant effect, and in some respects resemble cocaine (2, 3, 40, 44) mitraphylline is also a hypotensive (41). In connection with the use of Mitrogyna extracts as a febrifuge, it is of interest that rhynchophylline (mitrinermine) exhibits a significant antipyretic action (45, 46). The hypotensive effects of the total extracts (39) are, in part, owing to rhynchophylline (23). 

NSAIDs are commonly used for their analgesic, antiinflammatory, and antipyretic actions in the treatment of arthritis, musculoskeletal disorders, dysmenorrhea, and acute gout.Although these drugs are widely used and are often used for prolonged periods, retinal toxicity is rare. 

Antipyretic action cytokine-induced PG synthesis in the hypothalamus is blocked, thus reducing fever. 

The anti-inflammatory, analgesic and antipyretic actions of aspirin are those of NSAIDs in general... 

The phannacology of the salicylates and related compounds has been reviewed extensively by Smith." Salicylates. in general, exert their antipyretic action in febrile patients by increasing heat elimination of the body via the mobilization of water and consequent dilution of the blood. This brings about perspiration, causing cutaneous dilatation. 

Aspirin and ibuprofen are licensed for treatment of mild and moderate pain from a wide variety of causes, including dental and musculoskeletal pain and dysmenorrhoea, where their anti-inflammatory activity is particularly useful. They also have antipyretic action and are used in cold and flu medicines. 

Naproxen (200 mg every 8 to 12 hours with a full glass of liquid) is indicated for the relief of mild to moderate pain, treatment of primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Naproxen (Naprosyn) is used in juvenile arthritis. Naproxen, a nonsteroidal antiinflammatory agent, has analgesic and antipyretic actions. It should be used cautiously in patients with a history of angioedema or of... 

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