In human uterus

Somlyo Why do you need the apyrase Doesn t the human uterus have enough ecto-ATPase There is a lot of ecto-ATPase in most smooth muscles. Is it not high in human uterus ... 

Two isoforms of LC17 have been separated by 2D gel electrophoresis in human uterus (Cavaille et al.,... 

MMP-28 Epilysin Secreted Discovered in 2001, given its name due to have been discovered in human keratinocytes. Highly expressed in lung, placenta, salivary glands, heart, uterus, skin... 

Nickel retention in the body of mammals is low. The half-time residence of soluble forms of nickel is several days, with little evidence for tissue accumulation except in the lung (USEPA 1980, 1986). Radionickel-63 (63Ni) injected into rats and rabbits cleared rapidly most (75%) of the injected dose was excreted within 24 to 72 h (USEPA 1980). Nickel clears at different rates from various tissues. In mammals, clearance was fastest from serum, followed by kidney, muscle, stomach, and uterus relatively slow clearance was evident in skin, brain, and especially lung (Kasprzak 1987). The half-time persistence in human lung for insoluble forms of nickel is 330 days (Sevin 1980). 

According to results from clinical trials, the agonistic effects of tamoxifen detected in animals were also observed in the human uterus as it produces a trophic effect and an increase in the incidence of endometrial pathology, which is related to endometrial thickening (> 4 mm). Its use seems to be associated with an increase in endometrial cancer, which is related to the length of treatment and the accumulated dose of tamoxifen. Nevertheless, these tumors do not seem to be more aggressive or to have a worse prognosis than those found in women who do not follow this treatment or who receive hormone therapy. 

No studies were located regarding reproductive effects in humans after dermal exposure to disulfoton. In a 3-week study, in which disulfoton was applied to the shorn, unabraded skin of rabbits and left for 6 hours, 5 days/week, gross and histological examination of the testes, epididymides, ovaries, and uterus revealed no treatment-related lesions at <1.6 mg/kg/day (Flucke 1986). Slight... 

Much of the behaviour of humans and society as a whole is designed to provide an opportunity for a sperm and an ovum to meet in the uterus. However, sexual reproduction is not the only means of reproduction asexual reproduction occurs frequently in the animal kingdom and in many tissues in order to increase the number of cells during growth or to maintain the number due to cell death. The question arises, therefore, why sexual reproduction has arisen at all since it is very expensive in the use of resources for example, in the process of selecting a suitable mate, and in the requirement for males, whose only function in some species is fertilisation of the females, yet they use resources that could be used by the females and by the offspring. Perhaps because of this, a few species of vertebrates (e.g. some lizards) have retained the option for asexual reproduction. This process is known as parthenogenesis. Mammals, however, have lost this option. This... 

The lARC has classified nitrogen mustard HN-2 as probably carcinogenic to humans based on evidence that it causes leukemia in humans and cancers of the lung, liver, uterus, and large intestine in animals. ... 

The effect of catecholamines on the human uterus, which can be mediated by a- and /3-adrenoceptors, depends on its functional state. During pregnancy /32-adrenoceptor stimulation decrease the uteral tonus, an effect that can be used therapeutically. /32-Adrenoceptor agonists are in use as tocolytics. In the bladder base and the urethral sphincter a-adrenoceptors are present, mediating a contraction, whereas the /32-adrenoceptors of the bladder wall induce a relaxation of the particular smooth muscles present at these structures. Ejaculation is regulated by a-adrenoceptors. 

In humans, histamine generally has insignificant effects on the smooth muscle of the eye and genitourinary tract. However, pregnant women suffering anaphylactic reactions may abort as a result of histamine-induced contractions, and in some species the sensitivity of the uterus is sufficient to form the basis for a bioassay. 

The human uterus is a thick, muscular, pear-shaped organ composed of three major anatomical divisions—corpus, isthmus, and cervix (Figure 21.3). The main uterine cavity is known as the corpus and comprises the upper two-thirds of the uterus. It is several centimeters in... 

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