Uterine neoplasm

Connors AM, deSouza NM, Meindoe GA (2003) Adeno-myoma mimicking an aggressive uterine neoplasm on MRI. Br J Radiol 76 66-68... 

Kinkel K (2005) Pitfalls in staging uterine neoplasm with imaging a review. Abdominal Imaging 2005 Dec 5 [Epub ahead of print]... 

O Heavy smokers (greater than or equal to 15 cigarettes per day) over the age of 35, as well as patients with a history of thromboembolic disease, stroke, coronary artery disease, any estrogen-dependent neoplasm, or undiagnosed abnormal uterine bleeding, should not take estrogen-containing contraceptives. 

History of any estrogen-dependent neoplasm Undiagnosed abnormal uterine bleeding Pregnancy (known or suspected)... 

In a phase I clinical trial patients with recently resected urinary bladder cancer, uterine cervical intraepithelial neoplasm (CIN), oral leucoplakia, and intestinal metaplasia of the stomach were enrolled and treated with 0.5-12 g/... 

Contraindications to oestrogen therapy include women who may have an oestrogen-dependent neoplasm, e.g. breast cancer, who may be pregnant, or have a disposition to thromboembolism. Hypertension, liver disease or gallstones, migraine, diabetes, uterine fibroids or endometriosis may all be made worse by oestrogen. These are not necessarily absolute contraindications, and HRT should not for instance be denied to a poly-symptomatic woman with mild hypertension. If necessary, it may be permissible to treat both the hypertension and the postmenopausal symptoms with separate drugs. 

A 2 year study indicated some evidence of carcinogenicity in male rats (pheochromocytomas of the adrenal gland and neoplasms of brain and lung) and equivocal results in female rats (neoplasms of brain and lung) and male mice (lung neoplasms). Female mice experienced an increase in uterine cancer. 

In our series of 308 patients, 158 proved to have invasive pelvic neoplasms. As described in Section 3,4,3, fewer than 1.4% of healthy adult females have serum Mn-SOD levels above 130 ng/ml. Only 7 of the 39 patients (17.9%) with benign ovarian tumors had Mn-SOD levels exceeding 130 ng/ml. In the nonovarian gynecological malignancies group, 9 out of 40 patients (22.5%) with uterine cervical cancer and 8 of 40 patients (20.0%) with endometrial cancer had Mn-SOD levels above 130 ng/ml (Table 5). 

Rizeq MN, van de Rijn M, Hendrickson MR, Rouse RV. A comparative immunohistochemical study of uterine smooth muscle neoplasms with emphasis on the epithelioid variant. Hum Pathol. 1994 25 671-677. 

This is a very rare, possibly benign uterine tumor that is characterized by a cytologically bland and largely mitot-ically inactive proliferation of spindle cells in a myxoid matrix. The main differential diagnostic considerations include myxoid leiomyoma and leiomyosarcoma and endometrial stromal neoplasm with myxoid stroma. All inflammatory myofibroblastic tumors reported in the largest series were ALK-positive, which is similar to what has been described to occur in other sites. " All uterine mesenchymal neoplasms studied were ALK-negative, including smooth muscle and endometrial stromal tumors and carcinosarcomas. 

Grayson W, Taylor LF, Cooper K. Adenoid cystic and adenoid basal carcinoma of the uterine cervix Comparative morphologic, mucin, and immunohistochemical profile of two rare neoplasms of putative reserve cell origin. Am J Surg Pathol. 1999 23 448-458. 

Baker RJ, Hildebrandt RH, Rouse RV, et al. Inhibin and CD99 (M1C2) expression in uterine stromal neoplasms with sex-cordlike elements. Hum Pathol. 1999 30 671-679. 

Sherman ME, Bitterman P, Rosenshein NB, et al. Uterine serous carcinoma A morphologically diverse neoplasm with unifying chnicopathologic features. Am J Surg Pathol. 1992 16 600-610. 

It is employed in the treatment of functional uterine bleeding. It is also used in conjuction with an oestrogen in the treatment of menstrual disorders, neoplasms of the breast and endometrium. Sometimes it also finds its use in habitual and threatened abortion. 

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