Gynecological malignancies

The Role of Combined Chemotherapy and Radiation Therapy in the Treatment of Gynecologic Malignancies... 

This chapter will review trials of chemoradiation in cervical cancer, including the recent trials that established the value of this approach, and will discuss several questions that remain to be resolved regarding this treatment, including the ideal dose and schedule, and the effect of chemoradiation on compliance and complications. The last section of this chapter will briefly discuss the use of chemoradiation in the treatment of other gynecologic malignancies. 

A number of phase I and II trials of chemoradiation for gynecologic malignancies have included patients with vaginal or vulvar cancer, but the number of patients with these rare malignancies has been too small to support large randomized trials. 

Evans LS, Kersh CR, Constable WC, et al. Concomitant 5-fluorouracil, mitomycin-C, and radiotherapy for advanced gynecologic malignancies. Int J Radiat Oncol Biol Phys 1988 15 901-906. 

There was a 9% incidence of clinically important hypersensitivity reactions to paclitaxel in 450 women with gynecological malignancies treated with paclitaxel either alone or in combination regimens (50). There was a significant association between bee sting or animal allergy and paclitaxel hypersensitivity in 57 patients with a variety of tumors (51). 

MUd to moderate reduction in creatinine clearance with rises in serum urea and creatinine were reported in 14% of patients receiving carboplatin in a dose of 400 mg/m for gynecological malignancies. Of the patients who received carboplatin 400 mg/m with vincristine but without hydration for lung cancer, 19% developed renal changes. 

Serum Mn-SOD in Epithelial Ovarian Cancer and Other Gynecological Malignancies... 

We used ELISA with a monoclonal antibody against human Mn-SOD to investigate the possibility of using this enzyme as a marker for epithelial ovarian carcinoma. Serum samples were taken within 1 week before surgery or radiation therapy from 119 patients with pelvic masses and gynecological malignancies,... 

In our series of 308 patients, 158 proved to have invasive pelvic neoplasms. As described in Section 3,4,3, fewer than 1.4% of healthy adult females have serum Mn-SOD levels above 130 ng/ml. Only 7 of the 39 patients (17.9%) with benign ovarian tumors had Mn-SOD levels exceeding 130 ng/ml. In the nonovarian gynecological malignancies group, 9 out of 40 patients (22.5%) with uterine cervical cancer and 8 of 40 patients (20.0%) with endometrial cancer had Mn-SOD levels above 130 ng/ml (Table 5). 

Positivity Rate for Mn-SOD in the Serum of Patients with Benign Ovarian Tumors and Other Gynecological Malignancies of the Ovary... 

Sadeghi B, Arvieux C, Glehen O, et al. Peritoneal carcinomatosis from non-gynecologic malignancies results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000 88 358-363. 

Tashito H, Blazes MS, Wu R, et al. Mutations in PTEN ate frequent in endomettial carcinoma but tate in othet common gynecological malignancies. Cancer Res. 1997 57 3935-3940. 

S. Schmidt, U. Wagner, B. Schultes, P. Oehr, W. Decleer, W. Ertmer, H. Lubaschowski, H.J. Biersack, D. Krebs (1992). Photodynamic laser therapy with antibody-bound dyes. A new procedure in therapy of gynecologic malignancies. Fortschr. Med., 110, 298-301. 

E. Krimbacher, A.G. Zeimet, C. Marth, H. Kostron (1999). Photodynamic therapy for recurrent gynecologic malignancy a report on 4 cases. Arch. Gynecol. Obstet., 262(3-4), 193-197... 

N4. Nakanishi, H., Kodera, Y., Yamamura, Y., Kuzuya, K., Nakanishi, T., Ezaki, T., etal.. Molecular diagnostic detection of free cancer cells in the peritoneal cavity of patients with gastrointestinal and gynecologic malignancies. Cancer Chemother. Pharmacol 43(Suppl.), S32-S36 (1999). 

Sahn SA. Malignancy metastatic to the pleura. Clin Chest Med 1998 19 351-361. Negus RPM, Balkwill FR. Chemokines and gynecologic malignancies. In Chemo-kines and Cancer, BJ Rollins, ed. Totowa, NJ Humana Press 1999 193-205. Stricter RM, DiGiovine B, Polverini PJ, et al. C-X-C chemokines and lung cancer angiogenesis. Chemokines Cancer 1999 143-167. 

R560 L. Li and C. Zang, Analysis Technologies of Metabonomics and the Application in Gynecologic Malignant Tumor , Zhongguo Yufang Yixue Zazhi, 2010, 11, 638. 

Temkin SM, Yamada SD, Fleming GF. A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 2010 117(3) 473-6. 

Schwartz PE et al. (1975) Control of arterial hemorrhage using percutaneous arterial catheter techniques in patients with gynecologic malignancies. Gynecol Oncol 3 276-288 Seidman AD et al. (1993) Dose-intensihcation of MVAC with recombinant granulocyte colony- stimulating factor as initial therapy in advanced urothelial cancer. J Clin Oncol 11 408-414... 

Fehm T, Beck V, Banys M, Lipp HP, Hairass M, Reinert S, SoUmayer EF, Wallwiener D, Krimmel M. Bisphospho-nate-induced osteonecrosis of the jaw (ONI) incidence and risk factors in patients with breast cancer and gynecological malignancies. Gynecol Oncol 2009 112 (3) 605-9. 

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