Urinary bladder tumor

Stula EF, Barnes JR, Sherman H, et al. 1978. Liver and urinary bladder tumors in dogs from 3,3 -dichlorobenzidine. J Environ Pathol Toxicol l(4) 475-490. 

Of 25 workers involved in benzidine manufacture, 13 developed urinary bladder tumors and 4 renal tumors also occurred. The average duration of exposure was 13.6 years, and the average induction time from first exposure to detection of the first tumor was 16.6 years. Initial tumors made their appearance as late as 9 years after cessation of exposure. Airborne benzidine concentrations were estimated to have ranged from 0.005 to 17.6mg/m It is not known whether the cancers were influenced by concurrent exposure to other chemicals in the occupational environment. ... 

Of 111 rats given 20mg of DCB hy injection or gastric intuhation 6 days/week for 10-20 months, 17 had tumors of the zymbal gland (a specialized sebaceous gland adjacent to the external ear canal), 13 had mammary tumors, 8 had skin tumors, 5 had malignant lymphomas, 3 had urinary bladder tumors, 3 had salivary gland tumors, and 2 had intestinal tumors no tumors were found in 130 control... 

In hamsters, 0.3% DCB in the diet produced transitional cell carcinomas of the bladder and some liver cell tumors. Liver tumors were also found in mice exposed to DCB. Female dogs fed 8mg/kg/day for a period of 6-7 years had hepatocellular carcinomas and papillary transitional cell carcinomas of the urinary bladder tumors were absent in untreated controls. ... 

MOCA was fed to male and female mice for 18 months at a dose of either 1 or 2 g/kg in female mice, but not in males, a statistically significant incidence of hepatoma was observed. In addition, a higher incidence of hemangiosarcomas and hemangiomas was observed in treated animals compared with controls. Urinary bladder tumors (primarily papillary transitional cell carcinomas) occurred in dogs given 100 mg of MOCA by capsule for up to 9.0 years. ... 

Carcinogenesis An increase in urinary bladder tumors was observed in mice given topiramate (20, 75, and 300 mg/kg) for 21 months. The relevance of this finding to human carcinogenic risk is uncertain. 

Wei, M., Wanibuchi, H., Morimura, K. et al. (2002) Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis, 23(8), 1387-97. 

Urinary bladder tumors (iV-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat model) [42]... 

An important feature of Balkan nephropathy is its association with a high incidence of tumors of the renal pelvis and ureters, but not urinary bladder tumors [22, 94,95]. However, the difference between the incidence of upper urothelial tumors in endemic and non-endemic regions diminished in the last decades. In the sixties and seventies the incidence of these tumors was reported to be several dozen times higher in endemic than in non-endemic regions, while in the last decades this difference almost disappeared [21, 22, 94, 96, 97]. 

Methemoglobin formation was considered the most serious health outcome following exposure to 2NA until the increased rate of urinary bladder tumors were confirmed in the workers. Methemoglobinemia is symptom-less until acutely toxic. In one report workers exposed to 2NA were required to pass through the medical department following their shift so that any cyanosis could be ascertained. 

There have been reports of increased incidence of urinary tract tumors and thyroid tumors in rats exposed chronically to trifluralin. Trifluralin is structurally similar to ethalfluralin, which is a known carcinogen in rats, and formulations contain N-nit-roso-di- -propylamine, an omnipresent contaminant, also a known carcinogen. Trifluralin has been classified as a group C (possible carcinogen) due to evidence of increased combined malignant and benign urinary bladder tumors in female rats and renal pelvis carcinomas in male rats. There is also evidence for an increased incidence of thyroid and follicular cell tumors in male rats. 

Renal, Urinary Tract and Urinary Bladder Tumors... 

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