Mouse, urinary bladder tumors

Garbisa et al., 1980a). Tumor cells have been shown to cross the chorioallantoic membrane, mouse urinary bladder and canine blood vessels in vitro (Poste et al., 1980 Vlaeminck et al., 1972). Verification of active penetration of BM requires a direct interaction of cells with isolated intact BM. 

Tumor promotion activity has been demonstrated for a variety of agents in various organs butylated hydroxytoluene (BHT) in mouse lung (27), bile acids in colon (28), saccharin and cyclamate in rat urinary bladder (29), TPA in an vivo-in vitro rat trachea model (, 31), and phenobarbital (32-36) and polychlorinated biphenyls (34,, 38) in rat liver. 

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