United States pharmaceutical industry

The breakdown of on-site waste disposal practices from the United States pharmaceutical industry in 1995 and 2006 is shown in Table 3.4. Table 3.5 displays some of the commonly used solvents in the pharmaceutical industry and the amount of each directly released on-site in 1995 and 2006. As shown in Table 3.4, in 1995 the majority of on-site releases were due to stack emissions. By 2006 the amount of fugitive, stack, and water releases decreased significantly, whereas the amount of wastes injected underground remained the same. This suggests that... 

In the United States, pharmaceutical companies are the largest employer of industrial chemists, not just computational chemists.If the pharmaceutical... 

Reekie, W.D. Price and quality competition in the united states drug industry (Mimeographed). In Pricing New Pharmaceutical Products, Croom Helm London, 1977. 

Moreover, the industry evolved in a very different manner in the United States than in Europe. In Europe it quickly emerged from the chemical industry—that is, the first producers of modem pharmaceuticals in Europe were chemical companies with expertise in organic chemistry. In the United States the industry evolved in response to the advent of modern transportation and communication—the railroads and the telegraph—from which the Second Industrial Revolution derived. 

The pharmaceutical industry is one of the major contributors to health care in the United States. The industry is almost exclusively concerned with the provision of prescription and over-the-counter drugs to meet human needs, but veterinary drugs also represent a significant market segment. 

Eastman Goal Chemicals. In 1983 Eastman Chemical Co. became the first chemical producer in the United States to return to coal as a raw material for large-scale manufacture of industrial chemicals (35). In that year, Eastman started manufacturing acetic anhydride from coal. Acetic anhydride is a key intermediate for production of coatings, ceUulosic plastics, and cellulose acetate fibers. Acetic anhydride from other sources also is used in the manufacture of pharmaceuticals, starches and sweeteners, and flavors and fragrances. 

Full details of this work were pubHshed (6) and the processes, or variants of them, were introduced in a number of other countries. In the United States, the pharmaceutical industry continued to provide manufacturing sites, treating plasma fractionation as a normal commercial activity. In many other countries processing was undertaken by the Red Cross or blood transfusion services that emerged following Wodd War II. In these organisations plasma fractionation was part of a larger operation to provide whole blood, blood components, and speciaUst medical services on a national basis. These different approaches resulted in the development of two distinct sectors in the plasma fractionation industry ie, a commercial or for-profit sector based on paid donors and a noncommercial or not-for-profit sector based on unpaid donors. 

In 1995, discussions among the United States, the European Community (EC), and Japan occurred to achieve harmonization of dmg and dmg product standards and to provide guidance to the worldwide pharmaceutical industry for acceptance of global regulatory filings. The International Committee on Harmonization (ICH) has proposed initial guidelines for the estabUshment of stabihty studies. 

Alkali Meta.IPhospha.tes, A significant proportion of the phosphoric acid consumed in the manufacture of industrial, food, and pharmaceutical phosphates in the United States is used for the production of sodium salts. Alkali metal orthophosphates generally exhibit congment solubility and are therefore usually manufactured by either crystallisation from solution or drying of the entire reaction mass. Alkaline-earth and other phosphate salts of polyvalent cations typically exhibit incongment solubility and are prepared either by precipitation from solution having a metal oxide/P20 ratio considerably lower than that of the product, or by drying a solution or slurry with the proper metal oxide/P20 ratio. 

In 1993, the United States medical device industry employed 282,000 people, averaging a growth rate of about 4% since 1975. Research and development spending in this industry outpaced that in virtually every other industry. Over 7% of sales were spent on research and development in 1993, amounting to a Httle less than 3 bHHon. This rate reflects both the rapid rate of innovation and short product life-cycle. Medical devices become obsolete far more rapidly than pharmaceuticals (qv), forcing companies continuously to be innovative. 

The United States consumed 1500 metric tons of bismuth in 1988 and exported 147 t (1). The average domestic dealer price was 12.74/kg. The world mine output, excluding the United States, was estimated to be 2770 t in 1988 the world refinery production was estimated as 3510 t. Of the bismuth consumed in the United States, 679 t was used for industrial and laboratory chemicals, cosmetics (qv), and pharmaceuticals (qv) 333 t for fusible alloys 493 t for metaHurgical additives 12 t for other alloys and 15 t for miscellaneous purposes. 

Sodium Tetrahydroborate, Na[BH ]. This air-stable white powder, commonly referred to as sodium borohydride, is the most widely commercialized boron hydride material. It is used in a variety of industrial processes including bleaching of paper pulp and clays, preparation and purification of organic chemicals and pharmaceuticals, textile dye reduction, recovery of valuable metals, wastewater treatment, and production of dithionite compounds. Sodium borohydride is produced in the United States by Morton International, Inc., the Alfa Division of Johnson Matthey, Inc., and Covan Limited, with Morton International supplying about 75% of market. More than six million pounds of this material suppHed as powder, pellets, and aqueous solution, were produced in 1990. 

Pharmacopoeia publications provide a final important source of information for the pharmaceutical industry, regulatory authorities, and the healthcare professions. These are concerned with establishing quality standards. These publications include monographs that define specifications for the purity and identity of established pharmaceutical ingredients, both active and non-active, together with recognised analytical methods that may be used to evaluate them. The most relevant are the United States Pharmacopoeia (USP) and the European Pharmacopoeia (Ph.Eur). 

C03-0117. Heart disease causes 37% of the deaths in the United States. However, the death rate from heart disease has dropped significantly in recent years, partly because of the development of new drugs for heart therapy by chemists working in the pharmaceutical industry. One of these drugs is verapamil, used for the treatment of arrhythmia, angina, and h q)ertension. A tablet contains 120.0 mg of verapamil. Determine the following quantities (a) the molar mass of verapamil (b) the number of moles of verapamil in one tablet and (c) the number of nitrogen atoms in one tablet. 

---