Type IV collagenase

Strongin AY, Collier I, Bannikov G, Marmer BL, Grant GA, Goldberg GI. Mechanism of cell surface activation of 72-kDa type IV collagenase. J Biol Chem 1995 270 5331-5338. 

Rosenberg GA, Kornfeld M, Estrada E, Kelley RO, Liotta LA, Stetler-Ste-venson WG. TIM P-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase. Brain Res 1992 576 203-207. 

WANG, W., ZHOU, J., XU, L., ZHEN, Y., Antineoplastic effect of intracellular expression of a single-chain antibody directed against type IV collagenase, J. Environ. Pathol. Toxicol. Oncol, 2000,19, 61-68. 

Metalloproteases. The metalloproteases are so called because they require both calcium and zinc ions as cofactors. All known metalloproteases are secreted as inactive zymogens. The metalloproteases can be divided into three main groups (A4) interstitial collagenases, type IV collagenases, and the stro-melysins. 

H10. Hoyhtya, M., Hujanen, E., and T irpeenniemi-Hajanen, T., Modulation of type IV col-lagenase and invasive behaviour of metastatic melanoma (A2058) cells in vitro by monoclonal antibodies to type IV collagenase. Inti. J. Cancer 46, 282-286 (1990). 

KI3. Kossakouska, A. E., Urbanski, S. J., Huchcroft, S. A., and Edwards, R. R., Relationship between clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Oncol. Res. 4, 233-240 (1992). 

R2. Reith, A., and Rucklidge, G., Invasion of brain tissue by primary glioma Evidence for involvement of urokinase-type plasminogen activator as an activator of type IV collagenase. Biochem. Biophys. Res. Commun. 186, 348-354 (1992). 

MMP9 Matrix metalloproteinase 9 (gelatinase B, 92-Kd gelatinase, 92-Kd type IV collagenase)... 

Theaflavin (polycyclic benzopyran) Camellia sinensis (Theaceae) Type IV collagenase (20 pM) [94]... 

A role in metastasis has been proposed for TGF(3-1. For example, prostate tumor cell lines derived from focal pulmonary metastasis secrete high levels of TGF(3-1 and do not respond by growth inhibition, but by inducing the type IV collagenase matrix metalloproteinase-9 enzyme. This proteolytic enzyme degrades the basement membrane to facilitate invasion (S14). 

Turpeenniemi-Hujanen, T., Thorgeirsson, U. R, Rao, C. N. and Liotta, L. A. (1986). Laminin increases the release of type IV collagenase from malignant cells. J. Biol. Chem. 261,1883-1889. 

Wilhelm, S. M., Collier, I. E. Manner, B. L., Eisen, A. Z., Grant, G. A. and Goldberg, G. I. (1989). SV-40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J. Biol. Chem. 264(29), 17213-17221. 

Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, and Couser WG. Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am. J. Pathol. 1992 141(l) 85-98. 

Liabakk, N., Talbot, f.. Smith, R., Wilkinson, K., and Balk will, F. (1996), Matrix metallopno-tease 7 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer, Cdjicfr Res. 56,190-196. 

Strongjn, A.Y., Manner, B.L., Grant, G.A. and Goldberg, G.I. (1993). Plasma membrane dependent activation of the 72 kDa type IV collagenase is prevented by complex formation with TIMP-2. J. Biol. Chem. 268, 14033-14039. 

MMP-2 (type IV collagenase, gelatinase) (two major forms) Types I, II, III, IV, V, VII collagens, fibronectin... 

F7. Fujimoto, N., Mouri, N., Iwata, K., Ohuchi, E., Okada, Y., and Hayakawa, T., A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies. Clin. Chim. Acta 221, 91-103 (1993). 

H3. Hayasaka, A., Suzuki, N., Fujimoto, N., Iwama, S., Fukuyama, E., Kanda, Y., and Saisho, H., Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma. Hepatology 24, 1058-1062... 

M6. Margulies, I. M., Urinary type IV collagenase Elevated levels are associated with bladder transitional cell carcinoma. Cancer Epidemiology, Biomarkers, Prevention 1, 467 74 (1992). 

V3. Vartio, T., and Baumann, M., Human gelatinase/type IV collagenase is a regular plasma component. FEBS Letters 155, 285-289 (1989). 

Zll. Zucker, S., Mancuso, P., DiMassimo, B., Lysik, R. M., Conner, C., and Wu, C.-L., Comparison of techniques for measurement of gelatinase/type IV collagenases Enzyme-linked immunoassays versus substrate degradation assays. Clin. Exper. Metastasis 12, 13—23 (1994). 

---