Human lung fibroblasts

Human lung fibroblasts Unscheduled DNA synthesis - Waters et al. 1982... 

Weitbeig, A.B. and Corvesc, D. (1990). Translocation of chromosomes 16 and 18 in oxygen radical-transformed human lung fibroblasts. Biochem. Biophys. Res. Commun. 169, 70-74. 

Human lung fibroblasts Phosphate/sodium RP trap LCQ Proprietary (Davis et al., 2001)... 

Cytotoxicity assays employ mammalian celk in culture to measure cellular metabolic impairment and death resulting from exposure in vitro to soluble and particulate toxicants. Mammalian cells derived from various tissues and organs can be maintained as short term primary cultures or, in some cases, as continuous cell strains or lines. The cytotoxicity assays, incorporated as part of Level 1 analysis, employ primary cultures of rabbit alveolar (lung) macrophages (RAM) and maintenance cultures of strain WI-38 human lung fibroblasts. 

Atamna, H., PalerMartinez, A., and Ames, B. N. (2000). N-t-Butylhydroxylamine, a hydrolysis product of a-phenyl-N-f-butylnitrone, is more potent in delaying senescence in human lung fibroblasts. ]. Biol. Chem. 275, 6741-6748. 

Enzell. Effect of tobacco smoke compounds on the plasma membrane of cultured human lung fibroblasts. Toxicology 1980 15 203-217. 

Diphtheria toxin-resistant mutants were obsened in human epithelial type EUE cells but not in human lung fibroblasts exposed to epichlorohydrin in vitro. Epichlorohydrin... 

L.K. Limbach et al., Oxide nanoparticle uptake in human lung fibroblasts Effects of particle size, agglomeration, and diffusion at low concentrations. Environ. Sci. Technol. 39, 9370-9376 (2005)... 

Human lung fibroblasts DNA polymerase arrest, DNA-DNA crosslinks No data + Xu et al. 1996 Sodium chromate... 

Carlisle DL, Pritchard DE, Singh J, et al. 2000. Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI) Effect of ascorbate and tocopherol. Toxicol Sci 55 60-68. 

Kucich, U., Rosenbloom, J.C., Shen, G., Abrams, W.R., Hamilton, A.D., Sebti, S.M., and Rosenbloom, J. (2000). TGF-betal stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erkl/erk2. Arch Biochem Biophys 374 313—324. 

Wilhelm, S. M., Collier, I. E. Manner, B. L., Eisen, A. Z., Grant, G. A. and Goldberg, G. I. (1989). SV-40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J. Biol. Chem. 264(29), 17213-17221. 

Hernnas, J., Sarnstrand, B., Lindroth, P., Peterson, C.G.P., Venge, P. and Malmstrdm, A. (1992). Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblasts. Eur. J. Cell Biol. 59, 352-363. 

Clark, J.G., Dedon, T.F., Wayner, E.A. and Carter, W.G. (1989). Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts. J. Clin. Invest. 83, 1505-1511. 

Ahlgren T, Florin I, Jarstrand C, et al. (1983) Loss of surface fibronectin from human lung fibroblasts exposed to cytotoxin from Clostridium difficile. In Infect. Immun. 39 1470-1472. 

Florin I, Thelestam M (1981) Intoxication of cultured human lung fibroblasts with Clostridium difficile toxin. In Infect. Immun. 33 67-74. 

Florin I, Thelestam M (1983) Internalization of Clostridium difficile cytotoxin into cultured human lung fibroblasts. In Biocbim. Biophys. Acta, 763 383-392. 

MRC-5 human lung fibroblasts (ATCC deposit no. CCL-171 ECACC deposit no. 84101801). 

Fibroblasts are found frequently in connective tissue. Human lung fibroblasts may behave as inflammatory cells on activation by IL-4 and IL-13. The myofibroblast may contribute to the regulation of inflammation via the release of cytokines and to tissue remodeling. In asthma, myofibroblasts are increased in numbers beneath the reticular basement membrane, and there is an association between their numbers and the thickness of the reticular basement membrane. ... 

Sato, E., Nelson, D. K., Koyama, S., Hoyt, J., and Robbins, R. A. (2000). Erythromycin modulates eosinophil chemotactic cytokine production by human lung fibroblasts in vitro. Antimicrob. Agents Chemother 44, 401 06. 

Eickelberg 0, Roth M, Lorx R, et al. Ligand-independent activation of the glucocorticoid receptor by P2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999 274 1005-1010. 

Leira, F. et al., Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts, Toxicol. In Vitro, 15, 199, 2001. 

Malmstrom J, Westergren-Thorsson G. Heparan sulfate upregulates platelet-derived growth factor receptors on human lung fibroblasts. Glycobiology 1998 8 1149-1155. 

Scita, G., Aponte, G. W., and Wolf, G. (1993). Uptake and cleavage of /3-carotene by cultures of rat small mtestinal cells and human lung fibroblasts. In Methods in Enzymology (L. Packer, ed.), Vol. 214, pp. 21-32. Academic Press, San Diego, CA. 

Teran LM, M Mochizuki, J Bartels, EL Valencia, T Nakajima, K Hirai, JM Schroder. 1999. Thl- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol 20 777. 

Aldem KA, Ciesla SL, Winegarden KL, Hostetler KY (2003) Increased antiviral activity of l-0-hexadecyIoxypropyi-[ 2-(14)C] cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism. Mol Pharmacol 63 678-681... 

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