Tumorigenesis promotion

Wu, J.L., T. Abe, R. Inoue, M. Fujiki, and H. Kobayashi. IkappaBalphaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells. Neurol Res 26 785-91, 2004. 

In addition to their possible prooxidant activity (see above) polyphenols and flavonoids may influence cancer cells via their antioxidant properties. Recently, Jang et al. [219] studied cancer chemopreventive activity of resveratrol, a natural polyphenolic compound derived from grapes (Chapter 29). These authors showed that resveratrol inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. Flavonoids silymarin and silibinin also exhibited antitumor-promoting effects at the stage I tumor promotion in mouse skin [220] and manifested antiproliferative effects in rat prostate cancer cells [221]. 

After intramuscular injection, nickel sulphate failed to induce tumours in rats [460], However, orally administered nickel chloride had an apparent promoting effect on chemically-induced renal tumorigenesis [461]. 

Trosko JE, Jone C, Chang CC. 1983.The role of tumor promoters on phenotypic alterations affecting intercellular communication and tumorigenesis. Ann NY Acad Sci 407 316-327. 

API. 1989. Short-term dermal tumorigenesis study of selected petroleum hydrocarbons in male CD-I mice. Initiation and promotion phases Final Report API 36-32643. American Petroleum Institute Washington DC. 

Toxic effect. Water extract of the dried leaf, administered orally to adults, was inactive " ". Infusion of the dried leaf, administered in drinking water to male rats at a dose of 5%, was inactive "". Tumor-promoting effect. Seed oil, administered in ration to rats at a dose of 3.4% of diet, was active. Rats were given 7,12-dimethylbenz[a]anthracene to induce tumorigenesis "". 

Dietary olive and safflower oils in promotion of DMBA-induced mammary OE178 tumorigenesis in rats. Nutr Cancer 1990 13(3) 153-163. 

Berry DL, DiGiovarmi J, Juchou MR, et al. 1978. Lack of tumor-promoting ability of certain environmental chemicals in a two-stage mouse skin tumorigenesis assay. Res Commun Chem Pathol Pharmacol 20 101-108. 

Serraino, M. and Thompson, L.U. 1992. The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutr. Cancer 17, 153-159. 

A high fat diet may increase excretion of sterol metabolites in the gut, which in turn may promote tumorigenesis in the colonic epithelium. 

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