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Phenotypic alterations

Recently, the notion that the chronicity of inflammation may not actually drive the fibrogenic process has been widely appreciated (Tables 1, 2, and 3). Some propose that it is indeed the alteration of the mesenchymal cell phenotypes that disrupts the balance between collagen synthesis and degradation in the wound-healing process, highlighted by clinical evidence that shows unsuccessful treatment of fibrosis with anti-inflammatory or immunosuppressive drugs (18,19). One scenario is that mesenchymal cells (myofibroblasts and fibroblasts) are phenotypically altered and thus do not undergo apoptosis after resolution. [Pg.297]

Development of a colorectal neoplasm is a multistep process of genetic and phenotypic alterations of normal bowel epithelium structure and function leading to unregulated cell growth, proliferation, and tumor development. [Pg.702]

Degwert, J.S., Hoppe, U. and Kligman, L. H., In vitro model for contact sensitization I. Stimulatory capacities of human blood-derived dendritic cells and their phenotypical alterations in the presence of contact sensitizers, Toxicol, in Vitro, 11,613, 1997. [Pg.78]

Kamath, A.B., Nagarkatti, P.S., and Nagarkatti, M. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect... [Pg.343]

Determination of alteration in cell phenotype, altered cell products and/or function. [Pg.67]

Trosko JE, Jone C, Chang CC. 1983.The role of tumor promoters on phenotypic alterations affecting intercellular communication and tumorigenesis. Ann NY Acad Sci 407 316-327. [Pg.289]

De Smedt, A.C., Van Den Heuvel, R.L., Van Tendeloo, V.F., Berneman, Z.N., Schoeters, G.E., Weber, E. and Tuschl, H. (2002) Phenotypic alterations and 11-1 neta production in CD34( +) progenitor- and monocyte-derived dendritic cells after exposure to allergens a comparative analysis. Archives of Dermatological Research, 294, 109-116. [Pg.467]

Potential for acclimatization To what extent can increases in temperature be compensated through phenotypic alterations—acclimatizations Do some species have more acclimatization potential than other species ... [Pg.428]

Although glutathione is specifically decreased in kwashiorkor, blood levels of selenium-dependent glutathione peroxidase (a scavenger of peroxides) and vitamins A, C, and E (all members of the antioxidant machinery) are lower in both kwashiorkor and marasmus (Ashour et al., 1999). Why then are marasmic children, also deficient in some antioxidants, spared the oxidative stress Does a weakened antioxidant defense manifest as a serious threat only in the presence of pro-oxidant activities of the type encountered in kwashiorkor What is a possible trigger for the increase in free radicals, and how might this account for some of the phenotypic alterations in kwashiorkor ... [Pg.262]

Park KS, Jang YS, Lee H, Kim JS (2005) Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells. J Bacteriol 187 5496-5499... [Pg.131]

Park KS, Lee DK, Lee H, Lee Y, Jang YS, Kim YH, Yang HY, Lee SI, Seol W, Kim JS (2003) Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors. Nat Biotechnol 21 1208-1214... [Pg.131]

Interestingly, the variant ToxBF resembles LT rather than ToxB with respect to phenotypic alterations induced in cells (Eichel-Streiber et al., 1995). This suggests that the N-terminal amino acid alterations have somehow changed the activity of this toxin, and supports the assignment of the catalytic activity of all these toxins to the N-terminal domain. [Pg.151]

Hinton, D.E., S.J. Teh, M.S. Okihiro, J.B. Cooke and L.M. Parker. Phenotypically altered hepatocyte populations in diethylnitrosamine-induced medaka liver carcinogenesis - resistance, growth, and fate. Mar. Environ. Res. 34 1-5, 1992. [Pg.284]

The development of a colorectal neoplasm is a multi-step process of several genetic and phenotypic alterations of normal bowel epithelium structure and function, leading to unregulated cell growth, proliferation, and tumor development. Since the majority of colorectal cancers develop sporadically, with no inherited or familial disposition, efforts have been directed toward identifying these alterations and learning whether detection of such changes may lead to improved cancer detection and/or treatment outcomes. [Pg.2388]

Yu AS, McCarthy KM, Francis SA, et al. Knock down of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am J Physiol Cell Physiol 2005 288(6) C1231-C1241. [Pg.37]

Nouwen EJ, Verstrepen WA, Buyssens N, Zhu MQ, De Broe ME. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest 1994 479-493. [Pg.167]


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See also in sourсe #XX -- [ Pg.59 ]




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