Tumor rejection

Okugawa T, et al. A novel human HER2-derived peptide homologous to the mouse K-d-restricted tumor rejection antigen can induce HLA-A24-restricted cytotoxic T lymphocytes in ovarian cancer patients and healthy individuals. Eur J Immunol 2000 30 3338. 

Bloom MB, Perry-Lalley D, Robbins PF, et al. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med 1997 185(3) 453 59. 

Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Thery, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., Angevin, E., Amigoiena, S. and Zitvogel, L. (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 7, 297-303. 

Despite the fact that all of the so-called antitumor polysaccharides hitherto discovered proved totally without effect on autochthonous, animal tumors, some relationships may exist between the mechanism of allogeneic, transplanted-tumor rejection and the suppression of autochthonous tumors, as indicated by experiments of Tokuzen and Nakahara.253,254... 

Dobrzanski, M. J., J. B. Reome, and R. W. Dutton. 2001. Immunopotentiating role of IFN-gamma in early and late stages of type 1 CD8 effector cell-mediated tumor rejection. Clin Immunol 98 70. 

Tumor Immunity. At the present time it has not been resolved as to whether the primary in vivo mechanisms of lymphoid-mediated tumor rejection results from the activity of sensitized cytotoxic T cells or non-T natural killer cells (NK cells) (Herberman, 1981) or both. Several of the well-... 

A much slower kinetics of tumor rejection follows the local release of lL-10 by gene-transfected mouse mammary carcinoma cells (TS/A-IL-10)... 

Injection of immunocompetent or nude mice with P8I5 mastocytoma cells transfected with the gene of the CC chemokine MCP-3/CCL7 resulted in peri-tumoral accumulation of DCs and intratumoral recruitment of neutrophils [66]. The expression of CCRl and CCR3 (MCP-3 receptors) on neutrophils may be upregulated by IFN-y induced in T and/or NK cells so that they can directly respond to MCP-3 [70] or, alternatively, recruited by secondary dovmstream mediators. Removal of neutrophils caused an evident delay of MCP-3-elicited tumor rejection, suggesting their cooperative role in tumor inhibition. 

Di Carlo E, Coletti A, Modesti A, Giovarelli M, Fomi G, Musiani P Local release of interleukin-10 by transfected mouse adenocarcinoma cells exhibits pro- and anti-inflammatory activity and results in a delayed tumor rejection. Eur Cytokine Netw 1998 9 61-68. 

Giovarelli M, Cappello P, Fomi G, Salcedo T, Moore PA, LeFleur DW, Nardelli B, Di Carlo E, Lollini PL, Ruben S, Ullrich S, Garotta G, Musiani P Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes. J Immunol 2000 164 3200-3206. 

Soares MM, Mehta V, Finn OJ. Three different vaccines based on the 140-amino acid mud peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus mucl-transgenic mice with different potential for tumor rejection. J Immunol 2001 166 6555-6563. 

Tumor rejection antigen 700006 Chaperonin regulated by glucose, involved in innate and specific immunity, c [35]... 

Perez-Diez A et al. CD4 cells can be more efficient at tumor rejection than CD8 cells. Blood 2007 109 5346-5354. 

Imaizumi T, Kuramoto T, Matsunaga K, Shichijo S, Yutani S, Shigemori M et al. Expression of the tumor-rejection antigen SARTl in brain tumors. Int J Cancer 1999 83 760-764. 

After activation upon recognition of the CDld/2 complex, NKT cells release both helper T (Th) 1 and Th2 types of cytokines in large quantities. Thl-type cytokines such as interferon (IFN)-y mediate protective immune functions such as tumor rejection, whereas Th2-type cytokines such as interleukin (IL)-4 mediate regulatory immune functions to ameliorate autoimmune diseases. Thl and Th2 cytokines can antagonize each other s biological... 

Townsend SE, Allison JP (1993) Tumor rejection after direct costimulation of CD8 + T cells by B7-transfected melanoma cells. Science 259 368-370... 

VDUPl mice displayed immune system defects, including perturbed development and function of natural killer (NK) cells. There was a profound reduction in the numbers of NK cells and in NK activity in VDUP1 mice, which showed minimal changes in T and B cell development (Lee et al. 2005). The NK cell abnormality in the VDUP1 mice caused severe lymphoid hyperplasia in the small intestine and reduced tumor rejection (Lee et al. 2005). Moreover, the percentage of hepatic natural killer T (NKT) cells in VDUPl" " mice was decreased, and the percentage... 

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