Hyperplasia lymphoid

Dawley) 6hr/d Cardio 260 infection mucopurulent exudate in the nasal cavities lymphoid hyperplasia in the trachea and pneumonitis) ... 

Sneezing, tearing, reddened nose, and lesions of the nasal mucosa were observed in rats exposed at 200ppm for 6.5 hours/day, 5 days/week for 24 weeks. Histopathologic examinations showed squamous metaplasia, suppurative rhinitis, and lymphoid hyperplasia of the respiratory epithelium. 

Atrophy of lymphoid organs (spleen and thymus) and lymphoid hyperplasia in bronchial and mediastinal lymph nodes were observed in rats and mice exposed 6 hours/day for 12 of 16 days to 1.6 mg nickel/m as nickel sulfate, 3.6 mg nickel/id as nickel subsulfide, and 23.6 mg nickel as nickel oxide (Benson et al. 1987, 1988 Dunnick et al. 1988). The atrophy of the lymphoid organs was considered secondary to the decrease in body weight (Benson et al. 1987, 1988 Dunnick et al. 1988). According to the series of 16-day and 13-week studies by Haley et al. (1990), Benson et al. (1987,... 

B27. Burke, J. S., Waldeyer s ring, sinonasal region, salivary gland, thyroid gland, central nervous system and other extranodal lymphomas and lymphoid hyperplasias. In Neoplastic Hematopathology (D. M. Knowles, ed.), pp. 1351-1389. Lippincott Williams Wilkins, Philadelphia, PA, 2001. 

Immunotoxicity of Oligonucleotide Therapeutics The pro-inflammatory activity of the ASOs produces a constellation of effects, which includes splenomegaly, lymphoid hyperplasia, and multi-organ lymphohistiocytic cell infiltrate driven by the production of pro-inflammatory cytokines [57,63,75]. Incorporation of immunostimulatory sequences like unmethylated CG dinucleotides mimic bacterial DNA [76], Unmethylated CG dinucleotides interact with receptors of the innate immune system such as TLR9 to produce a shift toward T-helper type 1 immunity [77,78], Oligonucleotides with these motifs modulate the immune system. We have recently reported on a direct evaluation for effects on immune function. 

Other Chronic abuse of laxatives is accompanied by concerns of lipid pneumonia, lymphoid hyperplasia, and foreign-body reactions... 

To distinguish reactive atypical lymphoid hyperplasia from lymphoma... 

Follicles resnlt from focal lymphoid hyperplasia most commonly associated with chlamydial, viral, or toxic exposnre, inclnding preservatives in eyedrops or high levels of chlorine in pool water. Clinically, conjunctival follicles appear as avascular, translucent to whitish gray, amorphons nodnles 0.5 to 1.5 mm in diameter, usually located in the tarsal and fornix conjunctiva. Small external... 

Viraben R, Lamant L, Brousset P. Losartan-associated atypical cutaneous lymphoid hyperplasia. Lancet 1997 350(9088) 1366. 

In contrast, there have been several isolated reports of methotrexate-induced lymphomas (SEDA-21, 388) (SEDA-22, 417) (115,116). The pathological features in these cases have ranged from benign lymphoid hyperplasia to non-Hodgkin s lymphoma, and more rarely Hodgkin s disease (115), and patients usually had the typical features of lymphoproliferative disorders as found in immunosuppressed patients, that is, transplant patients or patients with congenital or acquired immune deficiency syndromes. Exceptionally, cases of pseudolymphoma have also been reported (SEDA-21, 389). 

In the other group, all the patients have been adults with a history of susceptibility to infection commencing between 19 and 29 years of age. These patients have presented with diarrhea, some evidence of malabsorption, and infestation with Giardia lamblia. Jejunal biopsy and radiology have revealed nodular lymphoid hyperplasia (H16). This syndrome is also seen with severe hypogammaglobulinemia in surviving adults (K4). Cases with isolated IgA deficiency where the absence of isoagglutinins has raised a suspicion of inadequate IgM are also described. 

The adult group have shown serum IgG levels from 25 to 50% MNA with IgA and IgM deficiency. The chief contrast with the children has been very low or absent isogglutinin titers. Cellular immunity appears to have been normal the nodular lymphoid hyperplasia seems to be a compensation for the humoral inadequacy indeed splenomegaly is also found in half these adults. 

G23. Gryboski, J. D., Self, T. W., Clemett, A., and Herskovic, T., Selective immunoglobulin A deficiency and intestinal nodular lymphoid hyperplasia correction of diarrhoea with antibiotics and plasma. Pediatrics 42, 833-837 (1968). 

K4. Kirkpatrick, C. H., Waxman, D., Smith, O. D., and Schimke, R. N., H3rpogamma-globulinemia with nodular lymphoid hyperplasia of the small bowel. Arch. Intern. Med. 121, 273-277 (1968). 

LYMPHOCYTE-PREDOMINANT THYMOMA VERSUS LYMPHOID HYPERPLASIA... 

Nodular lymphoid hyperplasia BALT has replaced the term pseudolymphoma and is characterized by reactive lymphoid proliferation that characteristically shows numerous lymphoid follicles with large germinal centers usually occurring in middle-aged people, most of whom are asymptomatic. Approximately 10% to 15% of patients have a collagen vascular disease such as systemic lupus erythematosus or an immune disease of uncertain etiology, and they frequently exhibit polyclonal gam-mopathy. Polytypic plasma cells are common. Marker studies show a mixed population of CD4- and CD8-positive T cells. Most cases occur as solitary nodules and reoccur in up to 15% of surgically excised cases. 

Baldassano MF, Bailey EM, Ferry JA, et al. Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma comparison of morphologic and immunophenotypic features. Am J Surg Pathol. 1999 23 88-96. 

Nihal M, Mikkola D, Horvath N, et al. Cutaneous lymphoid hyperplasia a lymphoproliferative continuum with lymphoma-tous potential. Hum Pathol. 2003 34 617-622. 

Gilliam AC, Wood GS. Cutaneous lymphoid hyperplasias. Semin Cutan Med Surg. 2000 19 133-141. 

Triscott JA, Ritter JH, Swanson PE, et al. Immunoreactivity for bcl-2 protein in cutaneous lymphomas and lymphoid hyperplasias./ Cutan Pathol. 1995 22 2-10. 

Figure 2.2-15 Nonspecific reactive lymphoid hyperplasia of a tracheobronchial lymph node in a cynomolgus monkey. Note the numerous reactive large germinal centers scattered deep in the paracortex.

Phenytoin causes hypertrichosis in 5% of patienls, which occurs several months after the initiation of therapy and is either slowly reversible, or irreversible even after discontinuation of medication. Phenytoin may also cause a hypersensitivity reaction, characterized by rashes, Stevens-Johnson syndrome, lymphoid hyperplasia, blood dyscrasias, and serum sickness. If any of these reactions occur, the medications must be discontinued. 

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