Polysaccharide antitumor

Enzymes Degrading Macromolecules. Enzymes that degrade macromolecules such as membrane polysaccharides, stmctural and functional proteins, or nucleic acids, have all shown oncolytic activity. Treatment strategies include the treatment of inoperable tumors with pepsin (1) antitumor activity of carboxypeptidase (44) cytotoxicity of ribonudease (45—47) oncolytic activity of neuraminidase (48—52) therapy with neuraminidase of patients with acute myeloid leukemia (53) antitumor activity of proteases (54) and hyaluronidase treatment in the management of human soHd tumors (55). 

MORiNAGA T (1985) Studies on an antitumor polysaccharide RBS derived fi om rice bran. 1. Preparation, physico-chemical properties, and biological activities of RBS. Yakugaku Zasshi, 105(2) 188-93. 

Design of Polysaccharide-5-Fluorouracil Conjugates Exhibiting Antitumor Activities... 

We have used of water-soluble polymers, such as polysaccharides, as carriers of antitumor agents to reduce their side effects [3]. In this study,... 

Mizuno TA, Development of antitumor polysaccharides from mushroom fungi, Food dr Food Ingred J 67- 3- 5, 1996. 

Chen R, meng F, Liu Z, Chen R, Zhang M. Antitumor activities of different fractions of polysaccharide purified from Ornithogalum caudatum Ait. Carbohydrate Polymers 2010 80 845-851. 

Rehmannia chinensis Fisch. R. glutinosa (Gaertn.) Libosch. Di Huang (Chinese foxglove) (root) Catalpol, campesterol, rehmannin, polysaccharide.16,33 Lower blood sugar, immuno-antitumor activity. 

N.A. Lobelia pulmonaria L. d-Usnic acid, thamnolic, polysaccharides, anthraquinones.154 Stimulate immune system, antitumor, cancer. 

Zhang, . P., X. Y. Lu, P. C. Ma, Y. Chen, Y. G. Zhang, and Z. Yan. 1993. Studies on diterpenoids from leaves of Tripterygium wilfordii. Acta Pharm. Sin. 28 110-115. Wang, J. Z., H. Tsumura, K. Shimura, and H. Ito. 1992. Antitumor activity of polysaccharide from a Chinese medicinal herb, Acanthopanax giraldii Harms. Cancer Lett. 65 79-84. 

Amino sugars are components of antibiotic substances109 and bacterial polysaccharides,1,0 and are therefore of interest. The nucleoside antibiotics amicetin, bamicetin, and plicacetin contain, as the sugar residue, a monoaminopentadeoxy disaccharide that is closely related to maltose. In view of the reported antibiotic and antitumor properties of these pyrimidine nucleosides,111,112 the synthesis of aminodeoxy derivatives of maltose would be of interest. 

The earliest antitumor-polysaccharide known was isolated in 194 from Serratia marcescens and became known as Shear s polysaccharide (Shear et al. 26)). Later on, a whole steries of polysaccharides of bacterial origin was tested and it became... 

In recent years, many fungi were examined for potent antitumor polysaccharides and a great number of different carbohydrate polymers could be isolated and shown to have a quite distinct antitumor activity. The most active ones have p-1,3- and 1,6-linkages and glucose as the main structural monomer. 

Belkin et al. 29> were first to examine various polysaccharide fractions from higher plants for their antitumor activity. They could demonstrate that many of these fractions produced haemorrhagic necrosis in different tumor types. In most cases, the polysaccharides were injected intraperitoneally into mice carrying Sarkoma 37 ascites tumor. The result was a progressive increase in cell volume and in cytoplasmic vacuolization. Osswald 30) found that tragacanth, gum arabic, and CMC reduced tumor cells in Ehrlich ascites carcinoma in female NMRE mice. The effect depended upon the dose, the route of injection, and the molecular size of the polysaccharides administered. 

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