Tissue neoplastic

The possibility of interfering with the structure or formation of nucleic acids with the aid of such antimetabolites obviously has great practical significance. An interference with growth of neoplastic tissue and influence on the genetic properties of an organism should be mentioned in the first place. 

Evers BM (2006) Neurotensin and growth of normal and neoplastic tissues. Peptides 27 2424—2433... 

Wyllie, A. 1-i. (1992) Apoptosis and the regulation of cell numbers in normal and neoplastic tissues an overview. Cancer Metastasis Rev. It, 95-103. 

Kim Y, Fischer SM. 1998. Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J Biol Chem 273 27686-27694. 

Because MIB-1 monoclonal antibody is used extensively to determine the cell proliferation index, its applications are discussed below. This antibody detects the nuclear antigen Ki-67 expressed in proliferating cells but not in resting cells. The antibody reacts with the nuclei of cells in mid-Gj (first gap), S (DNA synthesis), G2 (second gap), and M (mitosis) phases, but not in the G0 or quiescent phases. The use of MIB-1 antibody is one of the simplest and most reliable labeling techniques for assessing the rate of proliferation of a neoplastic cell population. Thus, the antibody can be used to assess the growth fraction (i.e., the number of cells in cell cycle) of normal, reactive, and neoplastic tissues. 

Vv=volume fraction of neoplastic tissue (%) as expressed in the area fraction of neoplastic tissue in the microscope field this is estimated subjectively in the same field in which the mitotic count is made. 

Since the 1990s several groups have used Raman spectroscopy to distinguish between normal and neoplastic tissue. The first studies looked at differentiating between normal tissue and advanced cancers in the breast [2] and... 

Chary, S.R. and Jain, R.K. (1989) Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. Proc. Natl. Acad. Sci. USA, 86, 5385-5389. 

Although it has long been recognized that intravenously injected porphyrins have an affinity for lymphatic and neoplastic tissues, it is only recently that radiolabelled metalloporphyrins have been screened for lymph node imaging - formerly porphyrins were detected by their fluorescence in target tissue. The studies of Vaum et al.285 have established that mIn-labelled tetra(4-N-methylpyridyl)porphyrin has a potential as a lymph node imaging agent. 

Number of neoplastic tissue culture colonies formed following culture of cells obtained from collagenase-dissociated target organ with metastatic foci. 

There is considerable evidence that rapidly growing neoplastic tissue consumes folate at so rapid a rate that folate deficiency megaloblastosis can occur in the host cells (14, 15). There is also evidence that vitamin B-12 deficiency may slow tumor growth, whether that deficiency results from inadequate absorption or elevated levels in serum of a vitamin B-12 binder which does not deliver the vitamin to tumor tissue (16), but will deliver it to the liver in a calcium-dependent fashion (14,... 

L9. Lignelid, H., Collins, V. P., and Jacobsson, B., Cystatin C and transthyretin expression in normal and neoplastic tissues of the human brain and pituitary. Acta Neuropathol. (Berl.) 93(5), 494-500 (1997). 

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