Tumor necrosis factor signaling

Wajant H, Pfizenmaier K, Scheurich P (2003) Tumor necrosis factor signalling. Cell Death Differ 10 45-65... 

Kim, W. J., Back, S. H., Kim, V., Ryu, I., andjang, S. K. (2005). Sequestration ofTRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions. Mol. Cell Biol. 25, 2450-2462. 

Wajant, H., Pfizenmaier, K., and Scheurich, P., Tumor necrosis factor signaling, Cell Death Differ., 10, 45, 2003. 

Veldman, R. J., Maestre, N., Aduib, O. M., Medin, J. A., Salvayre, R., and Levade, T., 2001, A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain potential implications in tumor necrosis factor signaling. Biochem. J. 355 859-868. 

Nur77 as a survival factor in tumor necrosis factor signaling. Proceedings of the National Academy of Sciences of the United States of America, 100, 8276-8280. 

Schutze, S, Nottrott, S., Pflzenmaier, K and Kronke, M. Tumor necrosis factor signal trans-... 

S21. Schutze, S., Scheurich, P., Pflzenmaier, K., and Kronke, M. Tumor necrosis factor signal transduction. Tissue-specific serine phosphorylation of a 26-kDa cytosolic protein. J. Biol. Chem. 264, 3562-3567 (1989). 

Crosstalk with TNF (Tumor necrosis factor) signaling pathway... 

Tumor necrosis factor receptor associated factors are a group of at least 6 proteins (TRAF 1-6), which are major signal transducers for the TNF receptor superfamily and the the interlukin-1 receptor/toll-like receptor (IL-1R/ TLR) superfamily. TRAF proteins are characterized by the presence of the TRAF domain at the the C-terminus,... 

Figure 43-13. Several signal transduction pathways converge on CBP/p300. Ligands that associate with membrane or nuclear receptors eventually converge on CBP/p300. Several different signal transduction pathways are employed. EGF, epidermal growth factor GH, growth hormone PrI, prolactin TNF, tumor necrosis factor other abbreviations are expanded in the text.

Liu IS, lohn GR, Sikora A, Lee SC, Brosnan CF (2000) Modulation of interleukin-1 beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. 1 Neurosci 20 5292-5299... 

Kraus J, Bomer C, Giannini E, HoUt V (2003) The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene. Mol Pharmacol 64 876-884 Law PY, Loh HH, Wei LN (2004) Insights into the receptor transcription and signaling implications in opioid tolerance and dependence. [Review] [123 refs]. Neuropharmacology 47(Suppl 1) 300-311... 

Pullen, S. S., Dang, T. T. A., Crate, J. J., and Kehry, M. R. (1999). CD40 signalling through tumor necrosis factor receptor-associated factors (TRAFs). J. Biol. Chem. 274, 14246-14254. 

Cope, A.P., Liblau, R.S., Yang, X.D., Congia, M., Laudanna, C., Schreiber, R.D., Probert, L., Kollias, G. and McDevitt, H.O. (1997) Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. Journal of Experimental Medicine 185, 1573-1584. 

Grinberg, M., Schwarz, M., Zaltsman, Y., Eini, T., Niv, H., Pietrokovski, S., and Gross, A. (2005) Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 25, 4579-4590. 

Early research showed that Pb exposure could increase sensitivity to bacterially-derived endotoxins [63] as well as increase production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) by macrophages [64-67], Studies in several species indicate that Pb boosts production of TNF-a both immediately following adult exposure and in later life following gestational exposure. Flohe and coworkers [67] reported that Pb-induced elevation in TNF-a production is sensitive to both protein kinase C signaling as well as protein production. Not only can the production of TNF-a be elevated following exposure to Pb, but also the expression of the receptor for TNF-a (TNF-R) is elevated [68], Therefore, the combined effect of elevated cytokine production by macrophages as well as increased receptor expression would be expected to contribute to problematic inflammatory responses. 

Yu, H.-S. et al., Arsenic Induces Tumor Necrosis Factor a Release and Tumor Necrosis Factor Receptor 1 Signaling in T Helper Cell Apoptosis, J. Invest. Dermatol., 119, 812, 2002. 

Liu, H. et al., Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin, Mol. Cell. Biol., 20, 2198, 2000. 

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