Tumor necrosis factor receptor-associated

Tumor necrosis factor receptor associated factors are a group of at least 6 proteins (TRAF 1-6), which are major signal transducers for the TNF receptor superfamily and the the interlukin-1 receptor/toll-like receptor (IL-1R/ TLR) superfamily. TRAF proteins are characterized by the presence of the TRAF domain at the the C-terminus,... 

Pullen, S. S., Dang, T. T. A., Crate, J. J., and Kehry, M. R. (1999). CD40 signalling through tumor necrosis factor receptor-associated factors (TRAFs). J. Biol. Chem. 274, 14246-14254. 

Liu, H. et al., Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin, Mol. Cell. Biol., 20, 2198, 2000. 

Zapata, J. M., et al., A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. / Biol Chem, 2001, 276(26), 24242-52. 

Arch, R. H., R. W. Gedrich, and C. B. Thompson, Tumor necrosis factor receptor-associated factors (TRAFs) — a family of adapter proteins that regulates life and death. Genes Dev, 1998, 12(18), 2821-30. 

Brown, K. D., B. S. Hostagee, and G. A. Bishop, Differential signaling and tumor necrosis factor receptor-associated factor (TRAP) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMPl)./ Exp Med, 2001, 193(8), 943-54. 

Bradley JR, Prober JS. 2001. Tumor necrosis factor receptor associated factors (TRAFs). Oncogene. 20 6482-6491. 

Hacker, H., Vabulas, R.M., Takeuchi, O., Hoshino, K., Akira, S. and Wagner, H. (2000) Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med., 192, 595-600. 

Uren, A.G., Pakusch, M., Hawkins, C.J., Puls, K.L., and Vaux, D.L. (1996). Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci USA 93,4974 1978. 

Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M (2001), Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress, J. Biol. Chem. 276 13935-13940. 

Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., and Watanabe, T. (1997). Tumor necrosis factor receptor-associated factor (TRAP) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol. Chem. 272, 2042-2045. 

Damay, B. G., Ni,J., Moore, P. A., and Aggarwal, B. B. (1999). Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and... 

Franken, M., Devergne, O., Rosenzweig, M., Annis, B., Kieff, E., and Wang, F. (1996). Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMPl. 

Gedrich, R. W., Gilfillan, M. C., Duckett, C. S., Van Dongen, J. L., and Thompson, C. B. (1996). CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins./. Biol. Chem. 271, 12852-12858. 

Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E. et al. (1996a). Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. JBC 271, 28745-28748. 

Mizushima, S., Fujita, M., Ishida, T., Azuma, S., Kato, K., Hirai, M., Otsuka, M., Yamamoto, T., and Inoue, J. (1998). Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). Gene 207, 135-140. 

Regnier, C. H., Tomasetto, C., Moog-Lutz, C., Chenard, M. P., Wendling, C., Basset, P., and Rio, M. C. (1995). Presence of a new conserved domain in CARTl, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma./. Biol. Chem. 270, 25715—25721. 

VanArsdale, T. L., VanArsdale, S. L., Force, W. R., Walter, B. N., Mosialos, G., Kieff, E., Reed, J. C., and Ware, C. F. (1997). Lymphotoxin-/ receptor signaling complex Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kB. PNAS 94, 2460-2465. 

Tumor necrosis factor receptor-associated protein with death domain, an adapter protein that recruits other proteins to the cytoplasmic TNF (tumor necrosis factor) receptor complex, involved in apoptosis... 

Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. 1998. The human toll signaling pathway divergence of nuclear factor kB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187 2097-101... 

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