Toll-like receptors signaling

IL-1 receptor associated kinase family-A with Toll-like receptor signalling. There are four members in this group to date IRAK-1,2,4 and M. They can phosphor-ylate among themselves, as well with other proteins involved in signalling such as TRAF-6. 

O Neill LA, Bowie AG (2007) The family of five TIR-domain containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7(5) 353-364... 

Yamamoto M. Sato S. Hemmi H. Hoshino K. Kaisho T, Sanjo H, Takeuchi O. Sugiyama M. Okabe M. Takeda K, Akira S Role of adaptor TRIP in the MyD88-independent toll-like receptor signaling pathway. Science 2003 301 640-643. 

Mast cells Sundstrom et al. (2004) Toll-like receptor signaling can reactivate HlV-1 replication, raising the possibihty that these cells can serve as an inducible reservoir... 

Brentano F, Kyburz D, Schorr O, Gay R, Gay S. The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 2005 233(2) 90-96. 

Hamasaki T, Uto TA et al (2010) Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(y-glutamic acid) nanoparticles. Clin Vaccine Immunol 17 748-756... 

Suzuki, N. et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416, 750, 2002. 

Akira, S. and Takeda, K. (2004) Toll-like receptor signalling. Nature Reviews in Immunology 4, 499-51 1. 

Anderson, K.V., Bokla, L., Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo-, the induction of polarity by the Toll gene product. Cell 42 (1985) 791-798. Baetz, A., Frey, M., Heeg, K., Dalpke, A.H. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem 279 (2004) 54708-54715. 

Burns, K., lanssens, S., Brissoni, B., Olivos, N., Beyaert, R., Tschopp, J. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.1 Exp Med, 197 (2003) 263-268. 

Hacker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.C., Wang, G.G., Kamps, M.P., et al., Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207. 

Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., et al., Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci USA 101 (2004) 15416-15421. 

Kagan, J.C., Medzhitov, R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006, 125 (2006) 943-955. 

Kawagoe, T., Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T., Akira, S. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol 10 (2009) 965-972. 

Keating, S.E., Maloney, G.M., Moran, E.M., Bowie, A.G. IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. J Biol Chem 282 (2007) 33435-33443. 

Mansell, A., Smith, R., Doyle, S.L., Gray, R, Fenner, J.E., Crack, P.J., Nicholson, S.E., et al., Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mai degradation. Nat Immunol 7 (2006) 148-155. 

McGettrick, A.F., O Neill, L.A. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol 41 (2004) 577-582. 

Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., Takada, H.. et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416 (2002) 750-756. 

Akira, S., Takeda, K. Toll-like receptor signaling. Nat Rev Immunol 4 (2004) 499-511. 

Oda K, Kitano H. A comprehensive map of the toll-like receptor signaling network. Mol. Syst. Biol. 2006 2 1-20. 

O Neill LA (2006) How Toll-like receptors signal What we know and what we don t know. Curr Opin Immunol 18 3-9. 

Beutler B (2004) Inferences, questions and possibilities in Toll-like receptor signaling. Nature 430 257-263. 

Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol, 171(8) 4304-4310. 

Coban, C., Ishii, K. J., Uematsu, S., Arisue, N., Sato, S., Yamamoto, M., Kawai, T., Takeuchi, O., Hisaeda, H., Horii, T., and Akira, S. (2007). Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19, 67-79. 

Togbe, D., Schofield, L., Grau, G. E., Schnyder, B., Boissay, V., Charron, S., Rose, S., Beutler, B., Quesniaux, V. F., and Ryffel, B. (2007). Murine cerebral malaria development is independent of toll-like receptor signaling. Am.. Pathol. 170,1640-1648. 

Toll-like receptor signaling TLR, MYD88, IRAK, TRAF6, ESCIT, MEKKl, NFkB, TAKl, TAB1,2, JNK, p38, lL-1, lL-12, TNFa Infectious diseases... 

Wells CA, Chalk A, Forrest A et al 2006 Alternative transcription of the toll-like receptor signalling cascade. Genome Biol 7 R10... 

Yang Y, Huang CT, Huang X, Pardoll DM. Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CDS tolerance. Nat Immunol 2004 5 508-515. 

Etoh, T. Kim, Y.P. Ohsaki, A. Komiyama, K Hayashia, M. Inhibitory Effect of Eiythraline on Toll-Like Receptor Signaling Pathway in RAW264.7 Cells. Biol. Pharm. Bull, 2013, 36, 1363-1369. 

Murakami Y, Tanimoto K, Fujiwara H, An J, Suemori K, Ochi T, Hasegawa H, Yasukawa M. Human herpesvirus 6 infection impairs Toll-like receptor signaling. Virol J. 2010 7 91. doi 10.1186/1743 22X-7-91. 

Carty M, Goodbody R, Schroder M et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 2006 7(10) I074-1081. 

Bowie A, Kiss-Toth E, Symons JA et al. A46R and A52R from vaccinia virus are antagonisu of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci USA 2000 97(18) 10162-10167. 

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