Tumor-associated glycoprotein

Monoclonal antibody-defined antigens, such as tumor-associated glycoproteins, CA-125 and CA 15-3... 

Recently, Oryza sativa L. japonica cv. Dongjin cell cultures were used to produce an antibody against the tumor-associated glycoprotein 72 (TAG 72). TAG 72 is commonly expressed in human adenocarcinoma cells. Recombinant antibody purified from transgenic rice cells was shown to bind human LS 174T colon adenocarcinoma cells expressing TAG 72. This proved the ability of rice cells to produce a functional foreign protein. 

B72.3 is a monoclonal antibody developed from the membrane-enriched fraction of breast carcinoma in a patient with hver metastasis. The B72.3 reactive antigen was purified and called TAG-72 (tumor-associated glycoprotein). Further purification of TAG-72 from LS-174T human colon carcinoma xenograft produced a new generation of monoclonal antibodies with higher affinity. These antibodies, denoted cc for "colon carcinoma, were used in subsequent studies. 

Thor A. Ohuchi N. Szpak C. A. et al. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res 1986. 46,3118-3124. 

Tumor-associated glycoprotein B72.3 Glycoprotein in a variety of adenocarcinomas Membrane-enriched fraction of metastatic breast carcinoma Gell Marque NA HIER... 

Thor A, Gorstein F, Ohuchi N, et al. Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3. J Natl Cancer Inst. 1986 76 995-1006. 

Orthoclone OKT3 (Muromo-mab CD3, murine Mab directed against the T-lympho-cyte surface antigen CD3) OncoScint CR/OV (Satumo-mab Pendetide, murine Mab directed against TAG-72, a tumor-associated glycoprotein)... 

It is thought that tumor-associated glycoproteins are often presented in clustered form. That is, an antigenic carbohydrate appendage is attached to a serine or threonine, and the resulting carbohydrate-amino acid motif is repeated in a series of residues. To more closely approximate a tumor cell surface, a carbohydrate construct was synthesized that presents Lewis y on three consecutive amino acids. 

OncoScint CR/OV (Satumomab Pendetide murine mAb directed against TAG-72, a high-molecular-weight tumor-associated glycoprotein) Cytogen detection/staging/ follow-up of colorectal and ovarian cancers 1992 (US)... 

Tubulin polymerization inhibitor 1172 Tumor angiogenesis 1278 Tumor associated antigen (TAA) 183 Tumor-associated glycoprotein 72, 1276 Tumor cell, targeting markers on 1276 Tumor growth index 523 Tumor hypoxia, assessment of 1263 Tumor necrosis factor (TN F) 7, 80, 264,... 

CA cancer antigen, CD cluster of differentiation, MUC mucin, TAG tumor-associated glycoprotein, EGFR epidermal growth factor receptor, MAG mercaptoacetyltriglycine, EC ethylcysteinate, HYNIC hydrazine nicotinamide... 

CEA carcinoembryonic antigen EGP epithelial glycoprotein 2 PSMA prostate-specific membrane antigen TAG tumor-associated glycoprotein 72. 

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