2,4,6-tris phenyl

Substituents in the phenyl groups of l. l-dimethoxy-2.4.6-tri-phenyl-phos-phorin have a small effect on the absorption spectra (Table 27). 

The absorption maxima of mixed l-carbo-l-hetero-2.4.6-tri-phenyl-A -phosphorins having R = alkyl or aryl and R = 0-alkyl, 0-aryl, or S-alkyl are given in Table 23 (p. 98). The electronic and steric effects of the substituents are similar to those previously discussed. 

The H-NMR spectrum of l.l-dimethoxy-2.4.6-tri-tert-butyI-X -phosphorin (Fig. 31), is in principle very similar to that of l.l-bis-diethylamino-2.4.6-tri-phenyl-X -phosphorin, or l.l-dimethylthio-2.4.6-tri-phenyl-X -phosphorin. The changes in the H-NMR spectra which accompany protonation of 1.1-hetero-X -phosphorins are discussed on p. 117. 

Only those 1.1-diphenyl-X -phosphorins in which the phosphorin ring is unsubstituted could be alkylated or acylated at the ring (see p. 77). The 2.4.6-tri-phenylated 1.1-disubstituted A -phosphorins cannot be alkylated by oxonium salts or acylated by acylchlorides under normal conditions. 

Not only oxidation but also thermolysis of X -phosphorins can lead to cleavage of both 1.1-substituents. According to Markl l.l-dibenzyl-2.4.6-triphenyl-X -phosphorin splits off 1.2-diphenylethane at temperatures higher than 220 °C to form 2.4.6-triphenyl-X -phosphorins22 (seep. 24). Other l.l-carbo-2.4.6-tri-phenyl-X -phosphorins also split off C groups at high temperatures to form 2.4.6-triphenyl-X -phosphorin. The mechanism of cleavage may involve radicals. 

In the nucleophilic displacement reaction of l.l-bis-diethylamino-2.4.6-tri-phenyl-X -phosphorin with thiophenol, the l.l-diphenylthio-2.4.6-triphenyl-X -phosphorin 197 does not survive the reaction temperature only trace quantities are formed. Thiophenol in refluxing benzene is thus an excellent means of removing dialkylamino groups. Besides diphenyldisulfide and diethylamine, this procedure affords good yields of 2.4.6-triphenyl-X -phosphorin 22. 1-Phenoxy-l-di-ethylamino-2.4.6-triphenyl-X -phosphorin 176 (see p. 89) is formed as a side product ... 

Similar mechanisms were proposed for the aromatization of 2,4,6-tri-phenyl-4//-pyran (151c) to 387b with aryldiazonium tetrafluoroborates,356 with 2,6-di-fe/Y-butylphenoxide radical, and tetracyanoquinone dimethide357 on the basis of kinetic and electrochemical experiments. Another free radical chain pathway for the reaction of 151c with trichloromethyl radical and tetrachloromethane was also postulated353 (Eq. 22). 

Figure 108. The Absorption Spectrum of REICHARDT s Dye [2,6-diphenyl-4-(2,4,6-tri-phenyl-l-pyridinio)phenoxide] at 25 °C. The formula of the dye is shown in the lower left comer of the diagram.

Methyl Acrylate CH2=CHCOOCH3 Non-inhibitors such as Biphenyl, Bibenzyl, Tri-phenyl, etc Methyl Acrylate Vap plus air > Ambient > 120 Inhibitor—H ydro quino ne or Methyl Ether of Hydro-quinone 10-20ppm. Store Store below 10° no inert atmosphere. No sparks 18.58-18.8 463 Self polymerizing above ambient press temp accelerates polymerization... 

Die Reduktion von 1-Chlor-l-nitro-2 bzw. 1-Chlor-l-nitroso-cycloalkanen3 durch Tri-phenyl-phosphan kann zur Herstellung von Lactamen verwendet werden z.B. ... 

Tricyclohexyltin hydroxide is metabolized in vivo to inorganic tin via di- and monocyclohexyltin derivatives (502), and in vitro studies suggested that the major, metabolic reaction is carbon-hydroxylation of the cyclohexyl group (503). Studies in vivo using either tri-phenyl[ Sn]tin acetate (467) or triphenyl[" Sn]tin chloride (504) in rats showed that these compounds are metabolized to yield substantial amounts of di- and monophenyltin derivatives, although no significant quantities of hydroxylated metabolites have been identified (503) in this case. 

A novel route to indoles and quinolines has been developed by sequential Wiltig and Heck reactions <96CC2253>. Thus, treatment of o-bromo- or iodo-lV-lrifluoroaceiylanilines (86) with a stabilized phosphorane affords the corresponding enamines 87 as a mixture of isomers. Cyclization to 88 is effected by heating with palladium acetate, tri phenyl phosphine, and bu.se. 

A. Preparation.—The first reverse Wittig olefin synthesis has been reported. Triphenylphosphine oxide and dicyanoacetylene at 160 °C gave the stable ylide (1 78%) the reaction was reversed at 300 °C. No comparable reaction was observed with a variety of other activated acetylenes but tri phenyl arsine oxide gave the corresponding stable arsoranes with dicyanoacetylene (— 70 °C), methyl propiolate, hexafluorobut-2-yne, dimethyl acetylene dicarboxylate, and ethyl phenylpropiolate (130 °C). 

Components Butylated triphenyl phosphate -100% triphenyl phosphate 15-20% t-Butylphenyl diphenyl phosphate 35-40% di(t-butylphenyl) phenyl phosphate 25-30% triphenyl phosphate 15-20% tri (p-t-butylphenyl) phosphate 6-10% butylated triphenyl phosphate 6-10% Mixed triaryl phosphate 50% mixed xylenyl phosphate = 50% tri phenyl phosphate 7-10%... 

Components Tributyl phosphate (79%) cycloaliphatic epoxide (2.0%) additives, including a triaryl phophate (21.0%) Mixture of 2-ethylhexyl diphenyl blend p-t-butyl phenyl blend triphenyl phosphate di(7-9-ii)Phthalate blend di-2-ethylhexyl phenyl phosphate Nonylphenyl diphenyl phosphate (-41%) cumylphenyl diphenyl phosphate ( 23%) tri phenyl phosphate (-36%)"... 

Product description Mixed triaryl phosphate Isopropylated triphenyl phosphate mixture Isopropylated triphenyl phosphate mixture Isopropylated tri phenyl phosphate blend... 

Dimerization(46,47) with a palladium acetate/tertiary phosphine complex (di-ace tate-bis--[ tri-phenyl phosphine] palladium) in the absence of air gives primarily the desired linear dimer with smaller amount of branched, cyclic, and heavy product (Equation 13.). The reaction product is a complex mixture of cis and trans geometric isomers which makes analysis difficult. In order to simplify this problem, the product analysis is made after hydrogenation over 5% palladium on carbon. 

In the presence of the C-20-ketogroup at the side chain, tetrazolium salts are reduced to the corresponding strongly colored formazans. Mader and Buck were the first to apply tri-phenyl tetrazolium chloride to assay pharmaceutical steroids [83], but it was later found that air affects the procedure leading to poor reproducibility [84,85]. More stable reagents such as 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium bromide [86] and 2,5-diphenyl-3-(p-strylphenyl)tetrazolium chloride [87] were employed successfully. Good results were also obtained with blue tetrazolium, or 3,3 -(3,3 -dimethoxy-4,4 -biphenylene) bis 2,5-diphenyl-... 

The complexes are soluble in aromatic solvents and in THF. The tri-p-tolyl-phosphine complex has limited solubility in ether, and the tri-phenyl phosphine complex is insoluble in diethyl ether. Both complexes are insoluble in hexane and related solvents and decompose in chlorinated solvents. Limited solubility is achieved inA jV-dimethylformamide, but moderate decomposition occurs. 

Als Kondensationsmittel besonders geeignet erwies sich das Tri-phenyl-methyl-Kalium, da es im Gegensatz zum Na-Salz in kochendem Ather bestandig ist (60). 

Die Reaktion von 1,2-Diamino-benzol mit Bis-[2,2,2-trifluor-l-trifluormethyl-ethoxy]-tri-phenyl-phosphoran fuhrt zur N-Monosubstitution unter Bildung von 2-Amino-l-(2,2,2-tr fluor-l-trifluormethyl-ethylamino)-benzol (62%)3 ... 

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