Tripartite

Vital Safety Evaluation of Biotechnology Products Derived from CeU Liaes of Human or Animal Origin," ICH Harmonized Tripartite Guideline,... 

Gasoline composition may also be regulated in Europe. A tripartite initiative is being carried out among the European Commission, the oil industry, and the automotive industry. Based on an analysis of the required improvements in air quaUty, new regulations are to be written that control vehicle emissions and fuel composition into the twenty-first century. 

Arents, G., et al., 1991. The nncleo.some core hi.stone octamer at 3.1 A re.s-olntion A tripartite protein a.s.sembly and a left-hand. snperhelix. Proceedings of the National Academy of Sciences U.S.A. 88 10148—10152. 

The anthrax toxin is a tripartite toxin and consists ofthe binding component protective antigen (PA), the lethal factor (LF), which is a metalloprotease, and the edema factor (EF), which is a calmodulin-dependent adenylyl-cyclase. Both enzyme components are translocated via PA into target cells. PA is activated by furin-induced cleavage and forms heptamers, which are similar to the binding components of C2 toxin and iota toxin. In the low pH compartment of endosomes, the heptamers form pores to allow translocation of LF and EF. LF cleaves six of the seven MEKs (MAPK-kinases) thereby inhibiting these enzymes. The functional consequence is the blockade of the MAPK pathways that control cell proliferation, differentiation, inflammation, stress response, and survival. Whether this is the reason for the LT-induced cell death of macrophages is not clear [1]. 

Conf) O) Anon, Tripartite Anti-Tank Trials and Lethality Evaluation. Part II. Volume I. 1. Warhead Design Data. 

The final draft is then presented to the Steering Committee in step 4 for adoption as an ICH Harmonised Tripartite Guideline. 

The 6a-carba-y -D-fructopyranose molecule may have this tripartite arrangement (AH, B, and X) in almost the same emplacement as has the y -D-fructopyranose molecule. 

Lindley proposed an oblique, planar, stereogeometric arrangement between AH,B and y that is strikingly similar to Kier s tripartite glucophore, with distance and direction parameters as shown in Fig. 12. A similar y site for other sweeteners, such as the sweet dipeptides, has also been proposed, and it appears that the location of y in relation to AH,B is directional rather than positional. 

The dimensions of the AH,B,y units proposed by Hough and Khan (see Fig. 17) approximate very closely to the interorbital dimensions of the Kier tripartite system (see Fig. 12). However, the discovery that replacement of the 4 -hydroxyl group of the D-fructofuranosyl group by a halogen atom produces derivatives that are very much sweeter than the 4,1, 6 -... 

If the assignment of the 1 -hydroxyl group and the 1-carbonyl group as the AH,B glucophore is correct, it is then very likely that the third (y) site is located at C-4, as inspection of a molecular model shows that this carbon atom could be in a position which approximates very closely the Kier or Shallenberger and Lindley tripartite glucophore. This could be readily confirmed by structural-modification studies. 

Araque A, Parpura V, Sanzgiii RP, Haydon PG (1999) Tripartite synapses gUa, the unacknowledged partner. Trends Neurosci 22 208-215... 

Petti M.A., Matheson S.F. and Burd G.D. (1999). Differential antigen expression during metamorphosis in the tripartite olfactory system of the African clawed frog, Xenopus laevis. Cell Tiss Res 297, 383-396. 

FIGURE 5.1 Graphical structure of a tripartite prodrug with self-immolative linker. (See the color version of this figure in Color Plates section.)... 

FIGURE 5.1 Graphical structure of a tripartite prodrug with self-immolative linker. 

FIGURE 5.2 Activation mechanism of a tripartite prodrug through enzymatic cleavage and elimination of an azaquinone methide. 

In recent years, regulatory authorities and industry associations have undertaken several important initiatives to promote international harmonization of regulatory requirements. These efforts are designed to enhance harmonization and are committed to seeking scientifically based harmonized technical procedures for pharmaceutical development. These efforts are undertaken under the auspices of the International Conference on Harmonization (ICH), which is organized to provide an opportunity for tripartite... 

While the tripartite countries of the more developed regions of the world have their own patent laws, and while they honor each other s property protection rights, some countries do not. Patent pirates in these countries freely copy (pirate) innovator drugs and drug products that are under patent protection in the United States and elsewhere without compensating patent holders. India is perhaps the worst pirate offender,... 

ICH (1994) ICH Topic Q2A (ICH Harmonised Tripartite Guideline) Validation of analytical methods Definitions and terminology (CPMP/ICH/381/95), ICH, London... 

Horsier, A. G., and Thompson, B. H., Fluidization in the Development of Gas Making Process, Proc. Tripartite Chem. Engr. Conf., pp. 51, Montreal... 

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