Synapse tripartite

Araque A, Parpura V, Sanzgiii RP, Haydon PG (1999) Tripartite synapses gUa, the unacknowledged partner. Trends Neurosci 22 208-215... 

Volterra, A., and Bezzi, P. (2002). Release of transmitters from glial cells. In The Tripartite Synapse Glia in Synaptic Transmission (A. Volterra, P. J. Magistretti, and P. G. Haydon, Eds.), pp. 164—182. Oxford University Press, UK. 

The disclosure of this active role of glia led to the model of the tripartite synapse (Araque et al, 1999 Bezzi and Volterra, 2001), where, besides the important tasks pursued by pre- and postsynaptic neuronal elements, a pivotal role in regulating synaptic function, strength, and plasticity is played by the glial cells surrounding the above-mentioned structures. 

Halassa MM, Fellin T, Haydon PG. 2007. The tripartite synapse Roles for gliotransmission in health and disease. Trends Mol Med 13 54-63. 

Kettenmann H, Filippov V (2002) Signaling between neurones and Bergmann glial cells, hr The Tripartite Synapse Gha in Synaptic Transmission (VolteiTa A, Magistretti PJ, Haydon PG, eds). New York Oxford University Press, pp 139—150. 

Nett W, McCarthy KD (2002) Hippocampal astrocytes exhibit both spontaneous and receptor-activated Ca + oscillations. In The Tripartite Synapse Gha in synaptic transmission (Volterra A, Mag-istretti PJ, Haydon PG, eds), pp 127-138. New York Oxford... 

A schematic rendition of the tripartite synapse, emphasizing the role of astrocytes in the management of excess glutamate and gliotransmitter release is described in Fig. 5.2. 

The plasma membrane of neurons and glial cells is equipped with a series of neiuotransmitter receptors and transporters that coordinate the functions of the tripartite synapse. However, an important particularity in the membrane composition of these cells has been overlooked. Both cell types express high levels of gangliosides, but with a distinct specificity. Neurons... 

Alger BE. Endocannabinoids getting the message across. Proc Natl Acad Sci USA. 2004 101(23) 8512-8513. Perea G, Navarrete M, Araque A. Tripartite synapses astrocytes process and control synaptic information. Trends Neurosci. 2009 32(8) 421-431. 

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