Trichothecenes diseases

In our research, we proposed a post amplification analytical method to detect F. culmorum, a pathogen causing foot rot and head blight diseases in cereals, and can produce mycotoxins such as zearalenone, deoxynivalenol, and other trichothecenes that can enter the food chain. The early identification of this fungal pathogen is therefore recommended in order to avoid crop losses and protect consumer health... 

Proctor RH Fusarium toxins Trichothecenes and Fumonisins in Cary JW, Linz JE, Bhatnagar D (eds) Microbial Foodbome Diseases Mechanism of pathogenesis and toxin synthesis. Lancaster, Technomic Publishing 2000, pp 363—381. 

Trichothecenes cause apoptosis and/or necrosis in the lymphoid, hematopoietic, and gastrointestinal systems resulting in leukopenia, vomiting, and diarrhea that can be lethal. In addition, trichothecenes are toxic to the skin and testes. Immune suppression and increased susceptibihty to infection may occur, especially in the late phase of the disease. The toxic effects from trichothecenes largely resemble those following radiation exposure (radiomimetic) due to effects on rapidly dividing cells in the intestine, bone marrow, and testis. 

Stachybotrys chartarum is one of the most commonly noted agents associated with so-called sick building or damp building-related syndrome and damp building-related illnesses (DBRI). While upper and some lower respiratory tract symptoms have been accepted as causally linked to human exposure to moldy damp indoor environments, other reported effects, including airflow obstruction, chronic obstructive pulmonary disease, pulmonary hemorrhage, neurologic effects and cancer, have not (Institute of Medicine, 2004). An excellent recent review of S. chartarum, associated trichothecene mycotoxins, and DBRI is available (Pestka et al, 2008). 

Horace Cutler organized the section on controlling plant diseases. These chapters discuss trichothecenes and their role in the expression of plant disease the role of phytoalexins in resistance of peanuts to... 

Trichothecenes and Their Role in the Expression of Plant Disease... 

As trichothecene mycotoxins cause several diseases in man and farm animal, such as red mold disease, staggering toxicosis, esophageal cancer, it is worthwhile to consider their importance in human and farm animal health. As ubiquitous environmental pollutants, trichothecene mycotoxins can assume great significance in the primary health care of community especially in rural community. 

Macrocyclic trichothecenes such as Satratoxin also were identified as causative toxicants. Since the 19th century, Alimentary Toxic Aleukia (ATA) or septic angina has been reported in the Soviet Union and symptoms of the disease were described as necrotic angina, leukopenia, hemorrhage, and exhaustion of bone marrow and death. 

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