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Toxins synthesis

Cells of C. reinhardtii were exposed to cell-free filtrates from A. flos-aquae, pure microcystin-LR or anatoxin-a, or combinations of the toxins. Both the position of the cells and the chlorophyll-a concentration of the cultures were observed for 12 days. Exposure to crude extracts as well as to combinations of the toxins significantly decreased chlorophyll levels in the cultures. Furthermore, these compounds were all capable of paralyzing the algae and thus promoted the settlement of C. reinhardtii cells. One intriguing aspect of this dynamic interaction is the separate finding that C. reinhardtii may actually induce toxin synthesis in A. flos-aquae (Kearns and Hunter 2000), essentially signaling its own demise. [Pg.113]

The characterization of the first functional cyanobacterial PPTase from Nodularia spumigena SORXQ was reported and its ability to modify carrier proteins from heterocyst glycolipid synthesis and nodularin toxin synthesis was demonstrated. This now opens the door to harness the biotechnological potential of cyanobacterial natural products formation. [Pg.461]

Cary JW, Bhatnagar D, Linz JE Aflatoxin Biological significance and regulation of biosynthesis in Cary JW, Linz JE, Bhatnagar D (eds) Microbial Foodbome Diseases. Mechanism of pathogenesis and toxin synthesis. Lancaster, Technomic Publishing, 2000, pp 317-361. [Pg.199]

Uchida, I., Makino, S., Sekizaki, T., Terakado, N. (1997). Crosstalk to the genes for Bacillus anthracis capsule synthesis by atxA, the gene encoding the trans-activator of anthrax toxin synthesis. Mol. Microbiol. 23 1229-40. [Pg.458]

Kimmitt PT, Harwood CR, Barer MR. Induction of type 2 Shiga toxin synthesis in Escherichia coli 0157 by 4-quinolones. Lancet 1999 353(9164) 1588-9. [Pg.2598]

Shute RE, Dunlap B, Rich DH (1987) Analogues of the cytostatic and antimitogenic agents chlamydocin and HC-toxin synthesis and biological activity of chloromethyl ketone and diazomethyl ketone functionalized cyclic tetrapeptides. J Med Chem 30(l) 71-78... [Pg.45]

Johnson RD, Johnson L, Itoh Y, Kodama M, Otani H, Kohmoto K. Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity. Mol Plant-Microbe Interact 13 742-753, 2000. [Pg.424]

Lasmezas, C.I., and Weiss, S. (2000). Molecular biology of prion diseases. In Microbial Foodborne Diseases. Mechanisms of Pathogenicity and Toxin Synthesis. Cary, J.W., Linz, J.E. and Bhatnagar, D., eds. pp. 495-537. Technomic Publishing Co., Inc., Lancaster. [Pg.267]

These life-threatening infections are best treated with penicillin plus clindamycin (to decrease toxin synthesis). [Pg.735]

Uchida I, Hornung JM, Thorne CB, Klimpel KR, Leppla SH. Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis. J Bacteriol. 1993 175 5329-5338. [Pg.476]

Several specific enzyme activities associated with precursor conversions in the aflatoxin pathway " " have been partially purified (Fig.l 1.1) whereas others such as methyltransferases " have been purified to homogeneity. Several other enzymes involved in aflatoxin biosynthesis, such as a reductase and a cyclase, " have also been purified from A. parasiticus. A desaturase that converts VERA to VERB has been found in cell-free fungal extracts. Matsushima et al. have purified and characterized two versiconal hemiacetal acetate reductases involved in toxin synthesis, whereas Kusumoto and Hsieh purified to homogeneity an esterase that converts VHA to versiconal. ... [Pg.229]

Fish, P.V., Pattenden, G., and Hodgson, S.T (1988) Marine toxins synthesis of the spiro-benzoquinonefuran unit in stypoldione. Tetrahedron Lett., 29, 3857-3860. [Pg.483]

Dichlorvos possesses a strong inhibitory effect on aflatoxin biosynthesis in A.flavus and A. parasiticus, presumably by specific enzyme inhibition. Dichlorvos inhibited 90% of the aflatoxin production by A. parasiticus ATCC 15517 (Hsieh, 1973). An early step in the secondary metabolic pathway was inhibited, as only additions of dichlorvos prior to the initiation of toxin production, which occurs 40 hr after incubation effectively stopped the toxin synthesis. The reduction in aflatoxin synthesis was accompanied by the excretion of versiconal acetate (19). Yao and Hsieh (1974) reported the efficient conversion of versiconal acetate (13.7%) into aflatoxin Bj by a nitrogen-free resting cell medium oiA. parasiticus. Averufin is converted into versiconal acetate, and not into aflatoxin Bj, in the presence of dichlorvos (Yao and Hsieh, 1974). [Pg.141]


See other pages where Toxins synthesis is mentioned: [Pg.111]    [Pg.281]    [Pg.76]    [Pg.460]    [Pg.633]    [Pg.853]    [Pg.115]    [Pg.115]   
See also in sourсe #XX -- [ Pg.3 , Pg.6 , Pg.12 ]




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