Triamines

Supplement (combined 1933 1740-1928 zidine, 314. Triamines, 294. Hydroxy-amines o-Aminophenol, 354. 

A second approach for the synthesis of 6-formylpterin (23) involves the condensation of triamin opyrimidinone (10) with 5-deoxy-L-arabinose (26). The key diol is obtained in four steps starting from compound (10). Cleavage of the diol side chain is achieved either with periodate (39) or with lead(TV) (40) to furnish 6-formylpterin (23) in 45% overall yield. 

Polymerization of castor od, chemical or oxidative, results in higher viscosity or bodied ods that are more usehd in urethane coatings than the untreated castor od (87). Other castor derivatives used to prepare urethanes are amides prepared by reaction of castor od and alkanolamines, amides of ricinoleic acid with long-chain di- and triamines, and butanediol diricinoleate (88,89). 

DETA has been produced by reaction of monoethanol amine [141-43-5] (MEA) and EDA with urea (42). In this process, MEA reacts with urea to form 2-oxa2ohdinone which then reacts with EDA to form the cycHc urea of diethylene-triamine. Hydrolysis of the ureaHberates the free amine. 

Heteroeyeles structurally based on the phenalene ring system form an interesting elass, frequently possessing distinetive eolours. With nitrogen as the central atom we have the unstable 9b-azaphenalene (24), whieh has only fairly reeently been prepared and is still comparatively little studied (76JCS(Pl)34l). The cyclazine nomenclature is commonly applied to this and related compounds thus, (24) is (3.3.3)cyclazine. With further aza substitution, in positions alternant to the central atom, their stability increases the heptaazaphenalene (25) is (thermally) a very inert compound, derivatives of which, e.g. the triamine, have been known since the early days of organic chemistry (see Chapter 2.20). 

H-Imidazole 1-oxide, 2,4,4,5-tetramethyl- H NMR, 5, 16 <83UP40100> 4H-Imidazole-2,4,5-triamine, hexaethyl-... 

Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone X-ray, 3, 339 (66JCS(A)639> Pyrimido[4,5-d]pyrimidine-4-thione pK 3, 339 (58JOC1451) Pyrimido[4,5-d]pyrimidine-2,4,7-triamine,... 

Pyrimidine-2,4,5-triamine, 6-hydroxy-as cofactor of phenylalanine hydroxylase, 1, 261 Pyrimidine-2,4,5-tri amines basic p/fa, 3, 61 Pyrimidine-2,4,6-triamines synthesis, 3, 115... 

Both ethylene and propylene oxide have been used in the preparation of adducts from a variety of amines, including ethylene diamine and diethylene triamine. The latter amine provides adducts which appetu" free of skin sensitising effects. 

Diethylene triamine Diethyl ether, see Ethyl ether Di(2-ethylhexyl)phthalate, see Di-sec-octyl phthalate Diethyl ketone Diethyl phthalate Diethyl sulphate Difluorodibromomethane Diglycidyl ether (DGE)... 

Diethyl aniline, 54 Diethylcarbaniazine citrate, 54 Diethyl carbamyl chloride, 54 Diethyl chlorophosphate, 54 Diethylene triamine, 54 Diethyl ether, 54 Di(2-ethylhexyl) phthalate, 54 Diethyl ketone, 54 Diethyl-p-phenylenediamine, 54 Diethyl phthalate, 54 Diethylstilbestrol, 55 Diethyl sulfate, 55 Diethyl zinc, 55 Difluoromethane chloride, 55 Digitoxin, 55 Diglycidyl ether, 55 Digoxin, 55 Diisobutyl ketone, 55 Diisopropylamine, 55 Diisopropyl ether, 55 DIKAMIN , 2,4-D, 55 DIKONIRT , 2,4-D, 55 Dimefox, 55 Dimethoate, 55 3,3 -Dimethoxybenzidine, 55 n,n-Dimethylacetamide, 56 Dimethylamine, 56 4-Dimethylaminoazobenzene, 56 Dimethylaminoethanol, 56 n,n-Dimethyl aniline, 56 7,12-Dimethylbenz[a]anthracene, 56 3,3 -Dimethylbenzidine, 56... 

The majority of analgesics can be classified as either central or peripheral on the basis of their mode of action. Structural characteristics usually follow the same divisions the former show some relation to the opioids while the latter can be recognized as NSAlD s. The triamino pyridine 17 is an analgesic which does not seem to belong stmcturally to either class. Reaction of substituted pyridine 13 (obtainable from 12 by nitration ) with benzylamine 14 leads to the product from replacement of the methoxyl group (15). The reaction probably proceeds by the addition elimination sequence characteristic of heterocyclic nucleophilic displacements. Reduction of the nitro group with Raney nickel gives triamine 16. Acylation of the product with ethyl chlorofor-mate produces flupirtine (17) [4]. 

In addition to a block copolymer, a microcapsule was made from suspension interfacial polycondensation between diacid chloride having aromatic-aliphatic azo group and aliphatic triamine [70,71]. The capsule was covered with a crosslinked structure having an azo group that was thermally stable but sensitive to light so as to be applicable to color photoprinting materials. 

The characteristic property distinguishing macrocyclic polyamines from their linear counterparts is seen in successive protonation. One is the higher N basicity to the first proton and another is a sudden drop of N basicities in the later stages of protonation. Table 1 lists the protonation constants (Eq. 1) for the macrocyclic polyamines in comparison with the corresponding values for their linear homologues. When a linear triamine (e.g. dien) 36,37) is cyclized to, say, (9)aneN3, the basicity of the first amine increases (log Kt = 10.59 us 9.70), but the basicity of the second and especially the third amine diminish (log K2 = 6.88 vs 8.95, log K3 < 1 vs 4.25)36)... 

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