Triamine complexes, platinum

Transplatin reacts 360 times faster than cisplatin with glutathione [27], a reaction likely to remove platinum from the cell, through ATP-dependent efflux [28]. It has been shown that a thioether ligand on a platinum triamine complex can be slowly replaced by a guanine-N(7), suggesting a possible platinum transporter role for such thioether compounds towards DNA [6], (This topic is discussed in the contribution by J. Reedijk and J. M. Teuben.)... 

C4Hi3Cl2N3Pt, Platinum(II), chloro(diethylene-triamine)-, chloride, 34 78 C4H13N3, Diethylenetriamine, platinum(ll) complex, 34 78... 

Cyclopalladated complexes of 2-(acetylpyridine)phenylhydrazone have been r twted the coordination sphere contains two nitrogen donors in addition to the aryl and halide ligands. Displacement of coordinated water from the palladium and platinum catimis [M(3-sulphonyl-pyridine)(Me2NC6H4)(OH2)] where the ortiio- metallated carbon atom is irons to the water ligand proceeds with a rate enhanconent of 10 to 10 relative to the cations [ML(OH2)] where L is a pentasubstituted triamine. Detailed kinetic studies suggest that the M-C bond labilises the water... 

---