Diethylene triamine penta-acetic acid

Fig. 8 Nanosystems that may function as simultaneous drug delivery and imaging agents for targeting T cells (a) liposomal systems, (b) solid biodegradable nanoparticulates, and (c) macro-molecular dendrimer complexes. PEG polyethylene glycol, Gd-DTPA gadolininum-diethylene triamine penta acetic acid. (Adapted from [48])...

Kim Kl, Bae J, Kang HJ, et al. Three-year clinical follow-up results of intracoronary radiation therapy using a rhenium-1 88-diethylene-triamine-penta-acetic-acid-filled balloon system, CircJ 2004 68 532-537. 

Chemical nature Diethylene triamine penta acetic acid pentasodium salt. 

Chan, H.K. Daciskas, E. Eberl, S. Robinson, M. Bautovich, G. Young, I. Deposition of aqueous aerosol of technetium-99m diethylene triamine penta-acetic acid generated and delivered by a novel system (AERx ) in healthy subjects. Eur. J. Nuclear Med. 1999, 26, 320-327. Denyer, J. Adaptive aerosol delivery in practice. Eur. Respir. Rev. 1997, 7, 388-389. 

Technetium-diethylene triamine penta-acetic acid (DPTA) aerosol scintigraphy... 

All salts and buffer components, as well as poly-D,L-lysine (PL), CBZ-protected PL, diethylene triamine penta-acetic acid (DTPA) and its anhydrides, water-soluble carbodiimide (l-ethyl-3-(dimethylaminopropyl)-carbodiimide, EDC), (SPDP), SMCC, dithiothreithol, succinic anhydride, trinitrobenzene sulfonic acid, triethylamine, bovine serum albumin (BSA), and IV-hydroxy sulfo-succinimide (HSSI) are available from Sigma (St. Louis, MO). 

In mammals, phenobarbital and pheny-toin increase serum ceruloplasmin concentrations. Chronic copper poisoning in sheep is exacerbated when diets contain heliotrope plants (Heliotropium sp., Echium spp.. Sene do sp.). Aggravated effects of the heliotrope plants include reduced survival and a 2-3-fold increase in liver and kidney copper concentrations when compared to control animals fed copper without heliotropes. Rats given acutely toxic doses of 2,3,7,8-tetrachlorodibenzo-para-dioxin had elevated concentrahons of copper in liver and kidney because of impaired biliary excretion of copper. Morphine increases copper concentrahons in the central nervous system of rats and dithiocarbamates inhibit biliary excretion. In human pahents, urinary excretion of copper is increased after treatment with D-penicihamine, calcium disodium EDTA, or calcium trisodium diethylene-triamine penta acetic acid. 

DPTA, diethylene triamine penta-acetic acid. 

DPTA = diethylene triamine penta-acetic acid BMA = 5,8-bis(carboxymethyl)-ll-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,841-tetra-azatridecan-13-oic acid BMEA = N,N -bis[methoxyethylamide] BOPTA = benzyloxypropionic tetra-acetic-acid DPCP = N,N -bis[pyridoxal-5-phosphate]-trans-l,2-cyclohexyldiamine-N , N -diacetic acid EOB-DTPA= ethoxybenzyldiethylene triamine penta-acetic acid BT-D03A= 10-[2,3-dihydroxy-l-hydroxymethylpropyl]-l,4,7,10-tetra-azacyclododecane-l,4/7-triacetic acid HP-D03A= 10-[2-hydroxypropyl]-l,4/7-tetra-azacyclododecane-l,4/7-triacetic acid DOTA= 1,4,7, 10-tetra-azacyclododecane-N,N, N",N "-tetra-acetic acid. 

Ca-DTPA (the calcium trisodium salt of diethylene triamine penta-acetic acid) has been used to remove various actinide elements from accidentally contaminated adults. Mays et al. (1) have pointed out that the dose predicted to kill the human foetus (as estimated from rat and mouse experiments) is within or under the range of the previously recommended daily dose of 26—36 /nmole Ca-DTPA. The toxicity of Ca-DTPA is largely due to the depletion of zinc and perhaps manganese, which causes inhibition of DNA synthesis. The authors suggest the use of the zinc salt of DTPA rather than Ca-DTPA. 

Specific extractants and sequential fractionation are also widely used procedures to estimate metal or nutrient availability to plants (see, e.g., Houba et al. 1996). Several extractants can be considered, like diethylene triamine penta acetate (DTPA), ethylene diamine tetra acetic acid (EDTA), acetic acid, HN03, HC1, or other... 

DTPA is diethylene-Triamine-NNN N N"-penta-acetic acid TAS does not reflect the inner sphere hydration Al(6), La(9)... 

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