Treatment of Impotency

EXTENSIONS AND COMMENTARY How does one classify this kind of compound It doesn t seem to be a psychedelic, at least at the levels reported. A stimulant There were no mentions made of any increase in cardiovascular activity. It sounds like an example of a tactile stimulant, not for treatment of impotence but with the potential of augmenting and enhancing sexual pleasure. 

Y ohimbine Treatment of impotence Pausinystalia johimbe Yohimbe... 

Yohimbine is used in the treatment of impotence, and as an aphrodisiac and mild hallucinogen. It is also used as a mydriatic and sympatholytic and has been suggested as an antidote to clonidine overdose. 

SaenzdeTejadal,GarveyDS,Schroeder JD, Shelekhin T, Letts LG, et al. 1999. Design and evaluation of nitrosylated-adrenergic receptor antagonists as potential agents for the treatment of impotence. J. Pharmacol. Exp. Ther. 290 121-28... 

The use of drugs for the treatment of impotence and other sexual disorders is very old. Yohimbine has been used in folk medicine by men and women for various forms of sexual dysfunction, mainly as an aphrodisiac for over a century. In the United States, yohimbine hydrochloride has been marketed and prescribed by doctors for more than 75 years (154). Be-... 

From Carcia-Reboll L, Mulhall JP, Goldstein I. Drugs for the treatment of impotence. Drugs Aging 1997 11 140-1 51. 

Gasser TC, Roach RM, Larsen EH, et al. Intracavernous self-injection with phentolamine and papaverine for the treatment of impotence. J Urol 1987 137 678-680. 

RS-15385) (1993JOC1935), proved to be a very efficient drug for the treatment of impotence. A laboratory procedure for its preparation on a kilogram scale was developed (1986MI1, 1992MI1). 

Other useful enzyme inhibitors include acetazolamide (Diamox) (carboific anhydrase inhibitor) for the treatment of glaucoma, congestive heart failure, epilepsy and motion sickness (a very useful drug ). Sildenafil (Viagra), famous for treatment of impotence, inhibits a phosphodiesterase enzyme (PDE5) that is involved in the breakdown of ATP. 

PGE, (alprostadil) may be used in the treatment of impotence. Intracavemous injection of PGE, causes complete or partial erection in impotent patients who do not have disorders of the vascular system or cavernous body damage. The erection lasts for 1 to 3 hours and is sufficient for sexual intercourse. PGE, is more effective than papaverine. The agent is available as a sterile powder that is reconstituted with water for infections (Caverject). 

Sildenafil citrate is a phosphodiesterase type 5 inhibitor that enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 in the corpus cavernosum of the penis. This results in vasodilation, increased inflow of blood into the corpora cavernosa, and ensuing penile erection npon sexnal stimulation. It is indicated in the treatment of impotence related to erectile dysfunction of the penis. 

PGE, (alprostadil) may be used in the treatment of impotence. Intracavemons injection of PGEi canses complete or... 

Urology PGEj (as alprostadil) is used in the treatment of impotence. Preparations are available for injection as well as for insertion into the urethra. 

Isosteres (i.e. molecules of the same shape but with different atom combinations) of purines are also important as medicines allopurinol is used to treat gout and Sildenafil achieved international fame, under the trade name Viagra, for the treatment of impotence. Some natural products can be viewed as purine isosteres oxanosine and tubercidin, both obtained from Streptomyces, have anti-microbial and anti-cancer activity. 

The aryl aminoalkylimidazolines (55) and (56) were prepared by either of the routes shown in Scheme 5.14. Phenamazoline (55) [57,58] is a vasoconstrictor, but its carbon analogue (58) is a vasodilator. Phentolamine (56) [59] is a non-selective adrenergic blocking agent [26,60,61] now used in conjunction with papaverine and prostaglandin El for the diagnosis and treatment of impotence [62, 63]. 

Bretan, P. N., Jr. 1989. History of the prosthetic treatment of impotence. Urol Clin North Am 16 1-5. Campbell, P. G. and L. E. Weiss. 2007. Tissue engineering with the aid of inkjet printers. Expert Opin Biol Iher 7 1123-1127. 

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