Drug efficiency

Tachyphylaxis is a loss of drug efficiency which develops in minutes or hours. Transmitter depletion and receptor desensitization are the basic mechanisms of this phenomenon. 

Silapharmaka often exhibit a stronger drug efficiency compared to the carbon analoga. They are derived from the latter by replacing tetravalent carbon by tetravalent silicon at the bioactive center. This is one more nice example of the analogy between tetravalent carbon and silicon. 

Preclinical studies Animal studies that support Phase I safety and tolerance studies and must comply with Good Laboratory Practice (GLP). Other preclinical studies are done in discovery research laboratories to support drug efficiency claims. 

Drug development is ideally a logical, step-wise procedure in which information from small early studies is used to support and plan later larger, more definitive studies. To develop new drugs efficiently, it is essential to identify characteristics of the investigational drugs in the early stages of development and to plan an appropriate development based on this profile. 

Mulato AS, Ho ES, Cihlar T. Nonsteroidal antiinflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exper Ther 2000 295 10-15. 

It is well-known that the addition of an organic cosolvent to water can dramatically change the solubility of drugs (Yalkowsky and Roseman, 1981). This fact is important for pharmaceutics because a poor aqueous solubility can often affect the drug efficiency. For this reason, the prediction of the solubility of drugs in aqueous mixed solvents or even a reliable correlation of the available experimental data is of interest to the pharmaceutical science and industry. 

The pharmaceutical market is very competitive. It is imperative that pharmaceutical companies (including biotechnology companies), large or small, discover and develop drugs efficiently and within the shortest time span to remain competitive. 

P-Lactam antibiotics show their lethal effect by inhibiting the synthesis of bacterial peptidoglycan, thereby disrupting the cell morphology and eventually resulting in cell lysis and death. Because the antibacterial effect of P-lactam is affected by the permeability of the outer membrane of bacteria, it is important in the evaluation of drug efficiency... 

Carboplatin + Improved drug stability, drug efficiency using cell culture [13]... 

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