Yohimbine hydrochloride

Processes for the isolation and purification of yohimbine have been described by Thoms, Feldhoff, Chemnitius, Schwyzer, Raymond-Hamet and others. Some of these processes have been modified to provide for estimation of the yield of yohimbine, usually as the hydrochloride, from the bark, or to facilitate the identification of this alkaloid in commercial yohimbe bark, which is apt to vary both in quality and in botanical origin.According to Witkop (1943) modern technical yohimbine hydrochloride may contain a little isoyohimbine but no allo-yohimbine. 

The same author has shown by repetition of the early experiments already referred to (p. 507) that when yohimbine hydrochloride is distilled with zinc dust there is formed in addition to harman (XVII), p-cresol, which must originate from ring E of the yohimbine formula (XIV) by inclusion of C as the methyl group. Witkop s formula for yobyrine (IV6) received prompt confirmation by Clemo and Swan s synthesis of this base by... 

R. Chiba and Y. Ishii, Simultaneous determination of yohimbine hydrochloride, strychnine nitrate and methyltestosterone by ion-pair high-performance liquid chromatography, J. Chromatogr., 588 344(1991). 

The reaction of yohimbine hydrochloride with m-chloroperbenzoic acid also results in the formation of a 7-chloro-indolenine derivative hence the product, following normal Ab-oxidation, is the JVb-oxide (141). In contrast to the 7-chloro-indolenine derivatives, no conversion into the corresponding oxindole analogue... 

Infra-red Spectrum. Principal peaks at wavenumbers 1705, 741, 1197, 1160,1290,1135 (yohimbine hydrochloride, KBr disk). 

Dose. Yohimbine hydrochloride has been given in doses of up to 30 mg daily. 

P-YOHIMBINE HYDROCHLORIDE see YBS500 P-YOHIMBIN HYDROCHLORIDE see YBS500 YOMESAN see DFV400... 

Holmberg, G., Gershon, S. 1961 Autonomic and Psychic Effects of Yohimbine Hydrochloride. Psychopharmacol. 2 93-106. 

The slimming aid LipoKinetix contains norephedrine hydrochloride, sodium usinate, 3,5-diiodothyronine, yohimbine hydrochloride, and caffeine. Seven patients all had the signs and symptoms of acute toxic hepatitis after taking this dietary supplement (176). Three patients had taken no other concomitant medications. All recovered spontaneously after LipoKinetix was withdrawn. 

Chemical Abstracts Service Registry Numbers CAS 146-48-5 (Yohimbine) CAS 65-19-0 (Yohimbine hydrochloride)... 

Yodoquinor diiodohydroxyquinoUne. yohimbine hydrochloride (Yohimex" ) is a complex alkaloid isolated from many plant species. It is a selective (02) a-ADRENOCEPTOR ANTAGONIST with ANTISYMPATHETIC... 

The use of drugs for the treatment of impotence and other sexual disorders is very old. Yohimbine has been used in folk medicine by men and women for various forms of sexual dysfunction, mainly as an aphrodisiac for over a century. In the United States, yohimbine hydrochloride has been marketed and prescribed by doctors for more than 75 years (154). Be-... 

Teloken C, Rhoden EL, Sogari R et al. Therapeutic effects of high-dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998 159 122-124. 

The crystal structure and absolute configuration of yohimbine hydrochloride have been reported. Sulphovanadic oxidation proves to be a good method ... 

Yohimbe contains the compound yohimbine ( 0.6-l.l%), from which the standardized drug yohimbine hydrochloride is derived (Betz et al. 1995 Chen et al. 2008). Yohimbine hydrochloride is a prescription drug used primarily in the treatment of male impotence, female hyposexual disorder, and sexual dysfunction caused by SSRI antidepressants, and to raise blood pressure (Tam et al. 2001). 

The compound yohimbine and prescription drug yohimbine hydrochloride are selective Oj-adrenergic receptor antagonists and produce dose-dependent increases in blood pressure with no effects on heart rate (Tam et al. 2001). 

A review of human clinical studies on the prescription drug yohimbine hydrochloride indicated that the majority of studies show that the drug induces a dose-dependent, transient, moderate increase in blood pressure but has no effect on heart rate, as would be expected for a selective a2-adrenergic receptor antagonist. The elevation of blood... 

Corynanthe yohimbe (Pausinystalia yohimbe Rubiaceae) is a evergreen tree native to the southern part of Africa and to Cameroon, Nigeria, and Zaire. Occasionally it is planted in tropical countries. Its bark coontains a total of 0.3%-1.5% alkaloids. The well known indole alkaloid yohimbine has been obtained as a major alkaloid from the bark. The bark has been used traditionally as an aphrodisiac by African natives. Yohimbine hydrochloride is used as an adrenergic blocker for humans. 

H26N2O11 f 14R, 16S-De(vindolinyl)catharinine, 44B, 536 H2 7BrN20i, Strychnine hydrobromide dihydrate, 15, 497 H27CIN2O3, Yohimbine hydrochloride, 39B, 422 H27NO, L-Methadone, 40B, 44 H27NO, Methadone, 39B, 422... 

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