Toxicity characteristic regulatory levels

CA. 1993b. California hazardous waste management regulations. 66260.24. Characteristics of Toxicity. Table I. Maximum concentration of contaminants for the toxicity characteristic. Regulatory Level. 

Another level of regulatory significance is the toxic characteristic leach procedure (TCLP) limit of a characteristic waste. A material which is a waste because of the TCLP is ha2ardous if a Hquor resulting from an 18-h leach in an acetic acid buffer exceeds 5 ppm (mg/L) lead in the leach Hquor. 

RCRA was passed to manage nonhazardous and hazardous wastes and underground storage tanks, with an emphasis placed on the recovery of reusable materials as an alternative to their disposal. This act introduced the concept of the separate management of hazardous and nonhazardous wastes, and defined procedures to identify whether a waste is hazardous or nonhazardous. A waste exhibits the characteristic of toxicity, classified as a hazardous material, if the concentration of any of 39 selected analytes in the Toxicity Characteristic Leaching Procedure (TCLP) extract exceed regulatory action levels. 

If a waste exhibits the TC, it carries the waste code associated with the compound or element that exceeded the regulatory level. Table 13.3 presents the toxicity characteristic waste codes, regulated constituents, and regulatory levels. 

Subpart B Criteria for Identifying the Characteristics of Hazardous Waste and for Listing Hazardous Waste Maximum concentrations of contaminants for the toxicity characteristic 7.5 mg/L (regulatory level) 40 CFR 261.24 ERA 1990a... 

EPA is faced with many tasks in the future development of the Toxicity Characteristic. These include the completion of work to develop transport equations for use in predicting the fate and transport of the elemental toxicants, development of regulatory thresholds for the remaining hazardous constituents listed in the RCRA regulations, and development of analytical methods to permit the measurement of the hazardous constituents in the TCLP extract at the health-based threshold level. We expect to complete these in a timely manner to meet the regulatory needs for the enhanced protection of human health and the environment. 

RCRA toxicity-characteristic component concentration greater than TCLP regulatory level. 

The toxieity eharaeteristics (TC) constituents include heavy metals, such as lead, silver, and arsenic pesticides and other organics. Regulatory levels have been established for the 39 TC constituents. The toxicity characteristic leaching procedure (TCLP) is the laboratory analysis required to determine if waste exeeeds the regulatory level and is thus a hazardous waste. If by the TCLP, waste is shown to leach 5 ppm of lead or greater, the waste is hazardous and has to be treated as such. Laboratory analysis is required before lead paint... 

Under RCRA, waste producers are required to take a cradle to grave approach to waste management. The producer of the waste is legally liable from the moment that waste is produced until its final disposal. A waste generator must identify waste material as hazardous waste if it is on a regulatory list or has a characteristic of flammability, toxicity, corrosivity, or reactivity. Once a material has been identified as hazardous waste, it must be clearly labeled and tracked when in transport. The waste must be treated in special facilities to low levels of contaminants. The final residual solid material, for example, incinerator ash, must be disposed into a registered hazardous waste landfill. 

Level 2 In the second level (Level 2), physico-chemical speciation models are introduced in order to correct the toxicity data for chemical availability. Indeed, NOEC and/or ECm values that are used in the effects assessment are generally generated in test media with varying physico-chemical characteristics (e.g. pH, hardness, DOC) known to alter metal availability and toxicity. In case metal concentrations are reported and appropriate speciation models (e.g. WHAM, MINTEQA2, etc.) and relevant input data (i.e. main physico-chemical parameters driving the availability of a metal such as pH, DOC, etc.) are available, NOEC and/or ECm values should be expressed on the basis of the metal species of concern in order to reduce uncertainty. Eor regulatory compliance purposes, the dissolved exposure concentrations should also be translated at the same level of availability (expressed in the same units) as the effects assessment. 

Many alkaloid biosynthetic enzymes have been localized to subcellular compartments other than the cytosol 260). Enzyme compartmentalization sequesters toxic alkaloids and pathway intermediates away from sensitive areas of the cell. The subcellular trafficking of biosynthetic intermediates might also create an important level of metabolic regulation. Understanding the subcellular compartmentalization of alkaloid pathways will show whether enzyme characteristics observed in vitro represent bona fide regulatory mechanisms in vivo. 

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