Tissue lesions

WarrenS. 1975. Skeletal and tissue lesions resulting from exposure to radium and fission products. Ann Clin Lab Sci 5 (2) 75-81. 

Rose, F.L. 1977. Tissue lesions of tiger salamander (Ambystoma tigrinum) relationship to sewage effluents. Ann. N.Y.Acad. Sci. 298 270-279. 

Indications of maternal toxicity include mortality or morbidity, clinical signs, reduced body weight gain, reduced food consumption, and differences in organ weights and organ/tissue lesions. Slight maternal toxicity does not necessarily result in developmental effects on the embryos, fetuses, or pups. Severe maternal toxicity, however, will always impact on the litter. 

Toxic responses can be divided into six types direct tissue lesions pharmacological, physiological, and biochemical effects teratogenesis immunotoxicity genetic toxicity and carcinogenesis. 

Physiological, pharmacological, and biochemical responses do not usually lead to a tissue lesion, although there may be organ failure as a result. They may result from interactions of chemicals with receptors or specific enzymes leading to anoxia, inhibition of cellular respiration, respiratory failure, changes in pH, temperature, blood pressure or electrolyte balance, for example. 

TISSUE LESIONS LIVER NECROSIS 7.2.1 Carbon Tetrachloride... 

Scanning electron microscopy (SEM) in concert with x-ray energy spectrometry (XES) has been used to detect silver in pulmonary, lacrimal sac, and skin tissues of individuals with diffuse interstitial lung disease, chronic dacryocystitis, and skin disorders, respectively (Brody et al. 1978 Loeffler and Lee 1987 Tanita et al. 1985). Brody et al. (1978) observed particles of preselected lesions of human pulmonary tissue magnified to 300x by SEM, and the silver content was analyzed by XES. The authors noted that SEM and XES techniques permit a rapid and conclusive determination of silver, silver compounds, and complexes in tissue lesions. 

Brody AR, Vallyathan NV, Craighead JE. 1978. Use of scanning electron microscopy and x-ray energy spectrometry to determine the elemental content of inclusions in human tissue lesions. Scanning Microse 2 615-622. 

Demonstration of Antigen and Specific Antibody in Tissue Lesions. 8... 

In the following sections methods for molecular characterization of chemokines from both cell culture supernatants and human tissue (lesional skin scales) will be described. 

Tissue lesions can be caused by local deposition of aluminium, for example in the eye (39)... 

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