Tissues elements

In addition to neurons and glial cells, the nervous system contains blood vessels, fibroblasts, and other connective tissue elements. In the PNS, processes from Schwann cells that form the multilayered myelin sheaths characteristic of peripheral myelinated nerves surround most neuronal elements. 

The accuracy of autopsy tissue elemental analysis has been assessed [247]. Results indicated that differences in elemental concentrations depend on age. Tissue of patients in chronic renal failure and treated by hemodialysis can accumulate higher concentrations of Cr and Al. Black particles observed in a spleen fragment from a patient who had previously had a hip replacement were found by ICP-MS to contain high titanium concentrations [248]. 

Internal controls, also known as built-in or intrinsic controls, contain the target antigen within normal tissue elements, in addition to the tissue elements to be evaluated. Thus, they can replace external positive controls. This is ideal, as the tissue elements to be evaluated... 

Positive control tissue shows adequate specific staining with little or no background staining. Specimen tissue shows little or no specific staining with variable background staining of several tissue elements. 

Background seen in all control tissue and specimen tissue. May see marked background staining in several tissue elements such as connective tissue, adipose tissue and epithelium. 

Examples of broad-spectrum and narrow-spectrum cross-reactivities are illustrated in Figures 10.5 and 10.6. Examples of unexpected staining of neural tissue elements are illustrated in Figures 10.7 and 10.8. Figure 10.8 also illustrates the very important point that large tissue sections are necessary for adequate evaluation of potential cross-reactivity. This particular crossreactivity was seen in glial cells, primarily in dorsal but not ventral white... 

This review is intended to provide helpful information regarding potential monoclonal antibody IgG test article (non-CDR-mediated) binding to specific tissues, cell types or other tissue elements, and subcellular locations following exogenous intravenous administration in animal model test systems. Particulars specific to other routes of administration were reviewed by Lobo et al. [1]. 

A distinctive status of the eye cornea morjrfiology of animals given CMS was epithelization of the whole wound surface. Epithelium growth with immersion into sub-epithelial layer was not observed. Peripheral zones of the wound were covered with a two- to three-layer epithelium wherein a considerable quantity of cells in mitosis was observed. In this zone, collagenic fibers of the cornea itself revealed chemosis, but regulation was observed. Epithelium of adjacent zones comprised four to five layers. In the central sites of the traumatized zone, fibrillogenesis proceeded with higher activity. In contrast to the control and coimective tissue, elements at the wound base contained a few necrotized structures, and much newly formed poorly differentiated connective tissue appeared. 

Tissue remodelling in normal healthy tissue is dependent upon continuous turnover of connective tissue elements. This requires dissolution of structural matrix proteins, and laying down of new structural components. Acute... 

Initial studies with mast cell cultures or granules demonstrated that mast cells appear to have several important effects on connective tissue elements. Subba Rao et al. (1983) showed that cultured rat embryonic skin fibroblasts phagocytose rat mast cell granules added to the culture medium or released by co-culmred mast cells, and that this is followed by secretion of collagenase and p-hexosaminidase. Similarly Yoffe et al. (1984) demonstrated that granules derived from mast cells purified from dog mastocytomas induced a 10- to 50-fold stimulation of collagenase production by human... 

Lesion Interrelationship of GFAP+ Cells Intracellular Distribution of GFAP Nuclear Features Other Tissue Elements... 

Permits identification of bacteria in the presence of debris from natural and environmental sources such as soil and dust, in the presence of tissue elements or body fluids in the case of clinical materials, and even in the presence of other types of bacteria. 

Additional Tissue element of species monitored (Liver, Muscle, Soft Body, WFD, SOE... 

Mature cartilage or bone lungs kidneys liver pancreas adrenal gland pituitary gland Fairly low Hypoplasia secondary damage to the fine vasculature and connective tissue elements... 

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