Time of Flight Ion Mobility Spectrometry

Differential ion mobility spectrometry Field asymmetric ion mobility spectrometry Ion mobility spectrometer Plasma chromatography Time-of-flight ion mobility spectrometry... 

One shortcoming of gas phase ion mobility spectrometry is its inability to maintain high resolving power at small scale. The separation efficiency of time-of-flight ion mobility spectrometry is limited by the low-field requirement, the speed of ion shutter gate relative to the drift time of analyte ion, and the space charge effect. 

Valentine, S.J., Kulchania, M., Srebalus Barnes, C.A., Clemmer, D.E. (2001). Multidimensional separations of complex peptide mixtures a combined high-performance hquid chromatography/ion mobility/time-of-flight mass spectrometry approach. Int. J. Mass Spectrom. 212, 97-109. 

Bushnell and co-workers [117] employed extensive molecular modelling to understand the nature of cis and trans isomerism in tetrahedral p-phenylene vinylene oligomers, and to aid the interpretation of time of flight mass spectrometry and ion mobility studies. Molecules such as T4R, shown in Figure 18, with four equivalent arms can be used to control the crystallinity in thin films. The authors reported the observation of a species in the mass spectrum resulting from the loss of an arm from the central carbon. This species will be referred to as P4R. 

Yuan YZ, Liu X, Boyd JM, Qin F, Li J, Li XF (2009) Identiflcation of N-nitrosamines in treated drinking water using nanoelectrospray ionization high-fleld asymmetric waveform ion mobility spectrometry with quadrupole time-of-flight mass spectrometry. J Chromatogr Sci 47(l) 92-96... 

MOS metal oxide sensor, MOSFET metal oxide semiconductor field-effect transistor, IR infrared, CP conducting polymer, QMS quartz crystal microbalance, IMS ion mobility spectrometry, BAW bulk acoustic wave, MS mass spectrometry, SAW siuface acoustic wave, REMPI-TOFMS resonance-enhanced multiphoton ionisation time-of-flight mass spectrometry... 

MALDI-Fourier transform ion cyclotron resonance mass spectrometry MALDI-Q-ion mobility-TOFMS MALDI-Quadrupole-ion-trap-TOF mass spectrometry MALDI-TOF-imaging mass spectrometry MALDI Time-of-flight mass spectrometry Magnetic resonance imaging Matrix solution fixation Moxifloxacin... 

Dong, L. Shion, H. Davis, R.G. Terry-Penak, B. Castro-Perez, J. van Breemen, R.B. 2010. Collision cross-section determination and tandem mass spectrometric analysis of isomeric carotenoids using electrospray ion mobility time-of-flight mass spectrometry. Anal. Chem. 82 9014-9021. 

Time Of Flight Secondary Ion Mass Spectrometry (TOF SIMS) analyses of Ecat and RV4+ from a commercial trial. Show that while the vanadium concentration may be higher on the surface of the particles, vanadium is found throughout the RV4+ particle, not only on the outer surface. The SIMS scan also shows that vanadium is found throughout the catalyst particle as well. This shows that over time, there is intraparticle mobility of vanadium in both catalyst and RV4+ particles[5]. 

SC Flenderson, SJ Valentine, AE Counterman, DE Clemmer. ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecular mixtures. Anal Chem 71 291—301, 1999. 

FIGURE 3.7 Graphical representation of CGC retention time (in minutes), mobility drift time (in milliseconds), and total ion intensity (in arbitrary nnits) of lavender oil. The highlighted peaks (in white boxes) show separation of analyte peaks by GC only, IMS only, and both CGC and IMS this dnal CGC and IMS techniqne enables a greater degree of separation for a complex mixture than with either technique alone. (From Crawford et al.. The novel use of gas chromatography-ion mobility-time of flight mass spectrometry with secondary electrospray ionization for complex mixtnre analysis, Int. J. Ion Mobil. Spectrom. 2010, 14, 23-30. With permission.)... 

FIGURE 3.15 Schematic of a typical DESI experiment. (From Weston et al. Direct analysis of pharmaceutical drug formulations using ion mobility spectrometry/quadrupole-time-of-flight mass spectrometry combined with desorption electrospray ionization Anal. Chem. 2005, 77(23), 7572-7580. 

Steiner, W.E. Clowers, B.H. English, W.A. Hill, H.H., Jr., Atmospheric pressure matrix-assisted laser desorption/ionization with analysis by ion mobility time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2004, 18(8), 882—888. 

Hoaglund-Hyzer, C.S. Clemmer, D.E., Ion trap/ion mobility/quadrupole/time-of-flight mass spectrometry for peptide mixture analysis. Anal. Chem. 2001, 73, 177-184. 

FIGURE 8.9 Selectivity induced by cation adduction. Ion mobility separation of methyl-p-D-galactopyranoside from its isomer methyl-a-D-galactopyranoside using different cation adducts. (From Dwivedi et al., Rapid resolution of carbohydrate isomers by electrospray ionization ambient pressure ion mobility spectrometry-time-of-flight mass spectrometry (ESI-APIMS-TOFMS), J. Am. Soc. Mass Spectrom. 2007, 18, 1163-1175. With permission.)... 

In addition to the number of types of spectrometers available for measuring ion mobility, numerous instruments are available for measuring mass. Thus, IMS-MS is combinatorial in nature. IMS instruments have been interfaced to quadrupole (Q) MSs, ion trap MSs, time-of-flight mass spectrometers (TOF-MSs), Fourier transform ion cyclotron resonance MSs, and most recently a Waters Synapt G-2 MS containing a quadrupole ion filter with a TW-IMS coupled with a TOF-MS. With these various IMS-MS configurations, high-resolution IMS-MS, IMS-MS, IMS-MS, IMS-MS-IMS-MS, IMS-MS -IMS-MS, and IMS-MS-IMS-MS spectrometry has been demonstrated. In the following sections, each type of ion mobility-MS is described. 

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