Mobility time of flight

Valentine, S.J., Kulchania, M., Srebalus Barnes, C.A., Clemmer, D.E. (2001). Multidimensional separations of complex peptide mixtures a combined high-performance hquid chromatography/ion mobility/time-of-flight mass spectrometry approach. Int. J. Mass Spectrom. 212, 97-109. 

Dong, L. Shion, H. Davis, R.G. Terry-Penak, B. Castro-Perez, J. van Breemen, R.B. 2010. Collision cross-section determination and tandem mass spectrometric analysis of isomeric carotenoids using electrospray ion mobility time-of-flight mass spectrometry. Anal. Chem. 82 9014-9021. 

Elaboration of nerve agent toxicokinetics requires sophisticated analytical tools to detect and, if possible, to quantify the free toxicants as well as adducts with proteins and enzymes. Analysis of OP nerve agents has been performed by capillary electrophoresis (CE), biosensors, matrix-assisted laser desorption/ionization (MALDI) MS, desorption electrospray ionization MS (DESI MS), ion mobility time-of-flight MS (IM-TOF MS), nuclear magnetic resonance spectroscopy (NMR), LC-UV, gas chromatography (GC), and many more techniques (Hooijschuur et al, 2002 John et al, 2008). 

SC Flenderson, SJ Valentine, AE Counterman, DE Clemmer. ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecular mixtures. Anal Chem 71 291—301, 1999. 

FIGURE 3.7 Graphical representation of CGC retention time (in minutes), mobility drift time (in milliseconds), and total ion intensity (in arbitrary nnits) of lavender oil. The highlighted peaks (in white boxes) show separation of analyte peaks by GC only, IMS only, and both CGC and IMS this dnal CGC and IMS techniqne enables a greater degree of separation for a complex mixture than with either technique alone. (From Crawford et al.. The novel use of gas chromatography-ion mobility-time of flight mass spectrometry with secondary electrospray ionization for complex mixtnre analysis, Int. J. Ion Mobil. Spectrom. 2010, 14, 23-30. With permission.)... 

Steiner, W.E. Clowers, B.H. English, W.A. Hill, H.H., Jr., Atmospheric pressure matrix-assisted laser desorption/ionization with analysis by ion mobility time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2004, 18(8), 882—888. 

FIGURE 9.3 Contourplots of nested drift time (bottom) and flight time (left) data for amix-ture of peptide ions that were formed by direct electrospray of a tryptic digest of cytochrome c. Projection of the data along the bottom and left axes shows ion mobility and time-of-flight dis-tribntions, respectively. (Taken from Henderson et al., ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecnlar mixtures, Anal. Chem. 1999, 71, 291. With permission.)... 

Steiner, W.E. Enghsh, W.A. HiU, H.H., Separation efficiency of a chemical warfare agent simulant in an atmospheric pressure ion mobility time-of-flight mass spectrometer (IM(tof)MS), Anal. Chim. Acta 2005, 532, 37-45. 

Steiner, W.E. Harden, C.S. Hong, R Klopsch, S.J. Hill, H.H. McHugh, V.M., Detection of aqueous phase chemical warfare agent degradation products hy negative mode ion mobility time-of-flight mass spectrometry [lM(tof)MS], J. Am. Soc. Mass Spectwm. 2006, 13, 241-245. 

Sobott, R Watt, S.I. Campuzano, I. The use of ion mobility/time-of-flight mass spectrometry for the study of protein conformations. Proc. 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, lune 1-5, 2008, ThP 067. 

C. A. S. Barnes and D. E. Clemmer, Ion mobility/time-of-flight analysis of combinatorial mixtures, High-Throughput Analysis, 187-216 (2003). 

FIGURE 20.7 Common active chemical agents and their less toxic simulant or structural analog. Source Steiner, W.E., et al. (2003) Secondary ionization of chemical warfare agent simulants atmospheric pressure ion mobility time-of-flight mass spectrometry. Analytical Chemistry, 75, 6068-6076. 

McLean, J. A., Russell, D. H. (2003) Sub-femtomole peptide detection in ion-mobility-time-of-flight mass spectrometry measurements. JProteome Res, 2, 427M 30. 

Olivova P, Chen W, Chakraborty AB, Gebler JC. Determination of N-glycosylation sites and site heterogeneity in a monoclonal antibody by electrospray quadrupole ion-mobility time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2008 22 29-40. Shimizu A, Ohe T, Chiba M. A novel method for the determination of the site of gluc-uronidation by ion mobility spectrometry-mass spectrometry. Drug Metab Dispos. 2012 40 1456-9. 

Verbeck, G. R, K. J. Gillig and D. H. Russell. 2003. Variable-temperature ion mobility time-of-flight mass spectrometry studies of electronic isomers of kr2+ and CH30TT+ radical cations. Eur. J. Mass Spectrom. 9 579-87. 

Glowers, B. Dwivedi, R Steiner, W. Hill Jr., H. H. Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry. Am. Soc. Mass Spectrom. 2005, 16,... 

The potential of the ambient pressure ion mobility time-of-flight mass spectrometry (AP IMS TOP MS) has been tested for the separation of different anomeric methyl glycosides derived from D-mannose, D-galactose, and D-glucose with the same anomeric configuration on Cl. To study the separation effect, Ag+, Ca Cu +, Hg2+ p j2+ acetates, and Co + and Pb + acetylacetonates were added to hexoses and their glycosides under different drift gas regimens (He, N2, Ar, and CO2). It could be... 

Guevremont, R. Sin, K. W. M. Wang, J. Y. Ding, L. Y. Combined ion mobility time-of-flight mass spectrometry study of electrospray-generated ions. Analytical Chemistry 1997, 69, 3959-3965. 

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