Nanoelectrospray ionization

Shen, Y., Zhao, R., Berger, S.J., Anderson, G.A., Rodriguez, N., Smith, R.D. (2002). High-efficiency nanoscale liquid chromatography coupled on-line with mass spectrometry using nanoelectrospray ionization for proteomics. Anal. Chem. 74, 4235 1249. 

Griss, P., Melin, J., Sjoedahl, J., Roeraade, J., and Stemme, G. (2002). Development of micromachined hollow tips for protein analysis based on nanoelectrospray ionization mass spectrometry./. Micromech. Microeng. 12, 682-687. 

Nanoelectrospray ionization flow rates range from a few nanoliters per minutes to a few hundred nanoliters per minutes nanoelectrospray is performed with pulled capillaries or on chips which serve as emitter... 

Yuan YZ, Liu X, Boyd JM, Qin F, Li J, Li XF (2009) Identiflcation of N-nitrosamines in treated drinking water using nanoelectrospray ionization high-fleld asymmetric waveform ion mobility spectrometry with quadrupole time-of-flight mass spectrometry. J Chromatogr Sci 47(l) 92-96... 

Benkestock, K. Sundqvist, G. Edlund, P. O. Roeraade, J. Influence of droplet size, capillary-cone distance and selected instrumental parameters for the analysis of noncovalent protein-ligand complexes by nanoelectrospray ionization mass spectrometry. J. Mass Spectrom. 2004, 39,1059-1067. 

Yau, P.M. and Burlingame, A.L. (2002) Identification of acetylation and methylation sites of histone H3 from chicken erythrocytes by high-accuracy matrix-assisted laser desorption ionization-time-of-flight, matrix-assisted laser desorption ionization-postsource decay, and nanoelectrospray ionization tandem mass spectrometry. Analytical Biochemistry, 306, 259-269. 

Nanoelectrospray ionization (nanoESI), also known as nanospray, nanoflow electrospray, and micro-electrospray, is a low flow/high sensitivity approach to ESI. NanoESI15 is a slight variation on ESI such that the spray needle has been made very small and is positioned close to the entrance of the vacuum of the mass spectrometer and the mass analyzer (Figure 6). This greatly reduces required sample amounts allowing nanoliter flow rates and femto-mole sample consumption. The end result is increased efficiency since the flow rates for... 

Erve, J. C. L., DeMaio, W., and Talaat, R. E. (2008). Rapid metabolite identification with sub parts-per million mass accuracy from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry. Rapid... 

Hatsis, P., Brockman, A. H., and Wu, J. T. (2007). Evaluation of high-field asymmetric waveform ion mobility spectrometry coupled to nanoelectrospray ionization for bioanalysis in dmg discovery. Rapid Commun. Mass Spectrom. 21 2295-2300. 

Ackermann, B. L., and Dethy, J. M. (2005). Understanding the role and potential of infusion nanoelectrospray ionization for pharmaceutical hioanalysis. In Using Mass Spectrometry for Drug Metabolism Studies (Korfmacher, W. A., Ed.). CRC Press, Boca Raton, pp. 329-356. 

Meng, Z., Qi, S., Soper, S.A., Limbach, P.A., Interfacing a polymer-based micro-machined device to a nanoelectrospray ionization Fourier Transform ion cyclotron resonance mass spectrometer Anal. Chem. 2001, 73, 1286-1291. 

Chen, S.-H., Sung, W.-C., Lee, G.-B., Lin, Z.-Y., Chen, P.-W., Liao, P.-C., A disposable poly(methylmethacrylate)-based microfluidic module for protein identification by nanoelectrospray ionization-tandem mass spectrometry. Electrophoresis 2001, 22(18), 3972-3977. 

A monolithic silica-based CIS stationary phase was used under high flow rate condition (2 mL/min) without significant back pressure in IPC analysis of a recently discovered new drug candidate for the treatment of Alzheimer s disease [15]. Nanoscale IPC using a monolithic poly(styrene-divinylbenzene) (PS-DVB) nanocolumn coupled to nanoelectrospray ionization mass spectrometry (nano-ESl-MS) was evaluated to separate and identify isomeric oligonucleotide adducts. Triethylammonium bicarbonate was used as the IPR. Interestingly, the performance of the polymeric monolithic PS-DVB stationary phase significantly surpassed that of columns packed with the microparticulate sorbents CIS or PS-DVB [16]. 

Cuyckens, F. Rozenberg, R. Hofftnaim, E. Claeys, M. 2001. Structure characterization of flavonoid 0-diglycosides by positive and negative nanoelectrospray ionization ion trap mass spectrometry. J. Mass Spectrom. 36 1203-1210. 

Figure 15.14. Determination of peptide sequence using nanoelectrospray ionization, and a very high-resolution mass analyzer (Q-TOF). In the first quadrupole, a doubly charged peptide ion of m/z — 625.41 was selected and later fragmented. The m/z CID spectrum yields the FGDYGSIDYGR sequence, shown at the top.23 [Reprinted, with permission, from E. Gustafsson, K. Thoren, T. Larsson, P. Davidsson, K. Karlsson, and C. L. Nilsson, Identification of Proteins from Escherichia coli Using Two-Dimensional Semi-Preparative Electrophoresis and Mass Spectrometry. Rapid Communications in Mass Spectrometry 15, 2001, 428-432. Copyright 2001 John Wiley Sons, Ltd.]...

Hop, C.E., Chen, Y., and Yu, L.J., Uniformity of ionization response of structurally diverse analytes using a chip-based nanoelectrospray ionization source, Rapid Commun. Mass Spectrom., 19(21), 3139, 2005. 

Figure 3. HCC-M proteins identified by nanoelectrospray ionization tandem MS/MS (nESI MS/MS).

Zamfir, A., Seidler, D. G., Schonherr, E., Kresse, H. and Peter-Katalinic, J. On-line sheathless capillary electrophoresis/nanoelectrospray ionization-tandem mass spectrometry for the analysis of glycosaminoglycan oligosaccharides. Electrophoresis, 25, 2010, 2004. 

Bacher, G. Szymanski, W. Kaufman, S. Zollner, R Blass, D. Allmaier, G., Charge-reduced nanoelectrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. J. Mass Spectrvm. 2001, 36(9), 1038-1052. 

Several innovative ion sources that are based on ESI were developed, including secondary electrospray ionization (SESI), desorption electrospray ionization (DESl) (Figure 4.4), and nanoelectrospray ionization (nESI). These were described in some detail in Chapter 3 in the context of sample introduction techniques and are only briefly discussed here. 

Kwasnik, M., Caramore, J., Fernandez, F.M., Digitally-multiplexed nanoelectrospray ionization atmospheric pressure drift tube ion mobihty spectrometry, AnaZ. Chem. 2009, 81, 1587-1594. 

Kwasiuk, M. Gonin, M. Fuhrer, K. Barbeau, K. Fernandez, F.M., Performance, resolving power and radial ion distributions of a prototype nanoelectrospray ionization resistive glass atmospheric pressure ion mobility spectrometer, Anal. Chem. 2007, 79, 7782-7791. 

Maziarz, P. E. Ill, Baker, G. A., Mure, J. V., and Wood, T. D. A comparison of electrospray versus nanoelectrospray ionization Fourier transform mass spectrometry for the analysis of synthetic poly(dimethylsiloxane)/poly(ethylene glycol) oligomer blends. Int.. Mass Spectrom., 202, 241, 2000. 

Liang, X.R. Xia, Y. McLuckey, S.A. Alternately pulsed nanoelectrospray ionization/ atmospheric pressure chemical ionization for ion/ion reactions in an electrodynamic ion trap. Ana/. Chem. 2006, 78, 3208-3212. 

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