Vaccine discovery

CONTEXTUALIZING THE IMPACT OF BIOINFORMATICS ON PRECLINICAL DRUG AND VACCINE DISCOVERY... 

Finding Targets for Therapeutic Intervention Bioinformatics and Vaccine Discovery Challenges... 

Immunoinformatics is a newly emergent subdiscipline within the informatic sciences that deals specifically with the unique problems of the immune system. Like bioinformatics, immunoinformatics complements, but never replaces, laboratory experimentation. It allows researchers to address, in a systematic manner, the most important questions in the still highly empirical world of immunology and vaccine discovery. 

I should like to thank all my colleagues, past and present, whose attitudes and opinions have helped to shape my views of drug and vaccine discovery. 

F. tularensis [18] and Shigella flexneri [19]. Once immunoreactive proteins are identified, these proteins are evaluated for their potential as vaccine candidates using a multifaceted algorithm [11]. An overall strategy in proteomics-based vaccine discovery is presented in Fig. 12.2. 

These property-oriented discovery technologies are specifically supramolecular since they are based on interactions between species. They present common features with procedures such as affinity chromatography, vaccine discovery and isolation by immunoprecipitation or induction of microbiological resistance. In their full expression, they involve three main steps diversity generation, effector selection and identification through encoding. 

In 2001, Brendan and his laboratory moved back to WEHI. He is currently a principal research fellow in the National Health and Medical Research Council of Australia (Canberra ACT, Australia) and an international fellow of the Howard Hughes Medical Institute (Chevy Chase, Maryland). The central theme of his studies is to address the molecular basis of host-parasite interactions, especially to aid vaccine discovery. He is especially interested in determining the function of merozoite antigens and their prospects as vaccines. He retains a focus on the development of genetic technologies to characterize the function of P. falciparum proteins, especially of those that are essential to blood-stage growth. 

N-Heterocycles in the synthesis of mimetics of polypeptides of /J-hairpin group as reagents for drug and vaccine discovery 00SL429. 

The synthesis of individual oligosaccharides, their conjugation to a protein, and immunization to produce antibodies recognizing the original polysaccharide is just the beginning of a very complex vaccine discovery process. The establishment of a S3mthetic oligosaccharide as an... 

A vaccine is a preparation used to prevent a specific infectious disease by inducing immunity in the host against the pathogenic microorganism. The practice is also called immunization. The first human immunization was performed in 1796 by Edward Jenner in England which led to the discovery of smallpox vaccine. However, classical vaccinology developed 100 years later, after the work by Louis Pasteur demonstrated that microorganisms are causes of diseases. 

Many early drug discoveries came from simple observations and experimentation with naturally occurring products. For example, the discovery of the first vaccine... 

Van Regenmortel, M. H. V. (1999c), Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure-function relationships in immunology , Vaccine, 18, 216-221. 

Sela, M., Arnon, R., and Schechter, B. 2002. Therapeutic vaccines realities of today and hopes for the future. Drug Discovery Today 7(12), 664-673. 

O Hagan, D.T. and Valiante, N.M., Recent advances in the discovery and delivery of vaccine adjuvants, Nature Rev. Drug Discov., 2, 727, 2003. 

The discovery of pharmaceuticals commences with the scanning of hundreds of compounds, whether with actual materials (irrational approach) or virtual simulations (rational approach). To discover biopharmaceuticals, we have to examine the compounds within us, for example, hormones or other biological response modihers, and determine how they affect the biological processes. In some cases, we study pathogens such as the influenza virus or bacteria to derive the vaccines. In other cases, we copy these biological response modifiers and use them as replacement therapy. 

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