Target finding

Protein target families are the fundamentals to build a framework for matching biological motifs with chemical scaffolds. Many structurally related targets find implications in different therapeutic areas, while exhibiting similar protein-ligand... 

Reverse Genetics baC Broad search for phenotype associated with perturbations of specific genes New role for target Select target Find specific inhibitor Broadly assay for phenotypes... 

The introduction of sensors for direction and distance measurements and the computer controlled automatic data flow were only a first step in the automation process. The rotatable parts of the theodolite had still to be moved manually and in addition target finding had to be performed by the operator. 

Fig. 5.4 Target finding based on region segmentation and feature extraction...

Today, for target finding, frequently CCD cameras are used. Tests have shown, that white circular targets produce the best accuracy while pointing. 

Target finding can base on region segmentation, if the position of the target is not well known and the scene is far away from the robot. 

Some other target finding systems have been developed. Generally, the choice of the method depends on the task to be performed (see e.g. Kahmen et al 1984). 

For a video theodolite a target finding system was developed, which can be used to monitor deformations of objects, being some hundred metres away. This system was used, to monitor the vertical deformations of a bridge (new Danube bridge of Bratislawa) due to different loads. 

The first step in chemical-genetics-based target finding is to perform cellular phenotypic screening to identify compounds that elicit a desired phenotype. An array of orthogonal secondary assays is then performed to remove nonspecific... 

The MBRU-12 design targets finding an optimum combination between the reliance on by-design and inherent safety features and the application of engineering (active and passive) systems to ensure a high level of plant safety. 

The phases of drug discovery are target finding, hit finding, hit to lead program or lead finding, lead optimization (sometimes pre-clinical candidate selection), and finally clinical candidate selection. 

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